Skin-derived precursor cells enhance peripheral nerve regeneration following chronic denervation

While peripheral nerves demonstrate the capacity for axonal regeneration, outcome following injury remains relatively poor, especially following prolonged denervation. Since axon-deprived Schwann cells (SCs) in the distal nerve progressively lose their ability to support axonal growth, we took the a...

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Veröffentlicht in:	Experimental neurology 2010-05, Vol.223 (1), p.221-228
Hauptverfasser:	Walsh, Sarah K., Gordon, Tessa, Addas, Bassam M.J., Kemp, Stephen W.P., Midha, Rajiv
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Analysis of Variance Animals Cells, Cultured Chronic denervation Denervation Male Motor Neurons - pathology Muscle Denervation Muscle, Skeletal - physiopathology Nerve injury Nerve Regeneration - physiology Peripheral nerve regeneration Peripheral Nervous System Diseases - physiopathology Peripheral Nervous System Diseases - surgery Rats Rats, Inbred Lew Schwann cells Skin - cytology Skin Transplantation - methods Skin-derived precursor cells Stem Cell Transplantation - methods Stem Cells - physiology Tibial Nerve - physiopathology Time Factors
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