Rikkunshito and 5-HT2C receptor antagonist improve cisplatin-induced anorexia via hypothalamic ghrelin interaction

Circulating ghrelin concentration regulates appetite behavior, but no study thus far has focused on the role of central ghrelin in anorexia after chemotherapy. To clarify the action mechanisms of rikkunshito (RKT), a traditional Japanese medicine, on cisplatin-induced anorexia, we attempted to eluci...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Regulatory peptides 2010-04, Vol.161 (1), p.97-105
Hauptverfasser:	Yakabi, Koji, Kurosawa, Susumu, Tamai, Mitsuo, Yuzurihara, Mitsutoshi, Nahata, Miwa, Ohno, Shino, Ro, Shoki, Kato, Shingo, Aoyama, Toru, Sakurada, Tomoya, Takabayashi, Hidehiko, Hattori, Tomohisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anorexia - chemically induced Anorexia - drug therapy Biological and medical sciences Cisplatin Cisplatin - pharmacology Drugs, Chinese Herbal - therapeutic use Eating - drug effects Eating - genetics Fundamental and applied biological sciences. Psychology Ghrelin Ghrelin - metabolism GHS-R1a Granisetron - pharmacology Hypothalamus Hypothalamus - drug effects Hypothalamus - metabolism Male Oligopeptides - genetics Ondansetron - pharmacology Quinoxalines - pharmacology Rats Rats, Sprague-Dawley Receptors, Ghrelin - genetics Reverse Transcriptase Polymerase Chain Reaction RKT Serotonin 5-HT2 Receptor Antagonists Stomach - drug effects Stomach - metabolism Vertebrates: endocrinology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!