To protect peptide pharmaceuticals against peptidases

Introduction: The major hurdle in the application and delivery of peptide pharmaceuticals is their rapid in vivo breakdown. Methods: We here combined two approaches to stabilize peptide pharmaceuticals, introduction of d-amino acids and cyclization, by applying an innovative enzymatic method. This m...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2010-03, Vol.61 (2), p.210-218
Hauptverfasser:	Rink, R., Arkema-Meter, A., Baudoin, I., Post, E., Kuipers, A., Nelemans, S.A., Akanbi, M. Haas Jimoh, Moll, G.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Aminopeptidase Animals Bacteria - enzymology Bacteria - genetics Carboxypeptidases - chemistry Cloning, Molecular Cyclization Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - chemistry Lactococcus Lactococcus lactis Lactococcus lactis - drug effects Lactococcus lactis - growth & development Lantibiotic Magnetic Resonance Spectroscopy Mass Spectrometry Methods NisB NisC Nisin - chemistry Peptide Hydrolases - chemistry Peptides - chemistry Plasmids - genetics Proteolytic Stereoisomerism Sulfides - chemistry Swine Therapeutic peptide Trypsin - chemistry
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