Beyond MHC: signals of elevated selection pressure on Atlantic salmon (Salmo salar) immune-relevant loci
Using Atlantic salmon (Salmo salar) as a model system, we investigated whether 18 microsatellites tightly linked to immune-relevant genes have experienced different selection pressures than 76 loci with no obvious association with immune function. Immune-relevant loci were identified as outliers by...
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| Veröffentlicht in: | Molecular ecology 2010-04, Vol.19 (7), p.1273-1282 |
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| container_title | Molecular ecology |
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| creator | Tonteri, A Vasemagi, A Lumme, J Primmer, C.R |
| description | Using Atlantic salmon (Salmo salar) as a model system, we investigated whether 18 microsatellites tightly linked to immune-relevant genes have experienced different selection pressures than 76 loci with no obvious association with immune function. Immune-relevant loci were identified as outliers by two outlier tests significantly more often than nonimmune linked loci (22% vs. 1.6%). In addition, the allele frequencies of immune relevant markers were more often correlated with latitude and temperature. Combined, these results support the hypothesis that immune-relevant loci more frequently exhibit footprints of selection than other loci. They also indicate that the correlation between immune-relevant loci and latitude may be due to temperature-induced differences in pathogen-driven selection or some other environmental factor correlated with latitude. |
| doi_str_mv | 10.1111/j.1365-294X.2010.04573.x |
| format | Article |
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Immune-relevant loci were identified as outliers by two outlier tests significantly more often than nonimmune linked loci (22% vs. 1.6%). In addition, the allele frequencies of immune relevant markers were more often correlated with latitude and temperature. Combined, these results support the hypothesis that immune-relevant loci more frequently exhibit footprints of selection than other loci. 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Immune-relevant loci were identified as outliers by two outlier tests significantly more often than nonimmune linked loci (22% vs. 1.6%). In addition, the allele frequencies of immune relevant markers were more often correlated with latitude and temperature. Combined, these results support the hypothesis that immune-relevant loci more frequently exhibit footprints of selection than other loci. They also indicate that the correlation between immune-relevant loci and latitude may be due to temperature-induced differences in pathogen-driven selection or some other environmental factor correlated with latitude.</description><subject>Animals</subject><subject>Atlantic salmon</subject><subject>Brackish</subject><subject>Environment</subject><subject>Evolution, Molecular</subject><subject>Expressed Sequence Tags</subject><subject>Freshwater</subject><subject>Gene Frequency</subject><subject>Genetics, Population</subject><subject>Genomics</subject><subject>Genotype</subject><subject>Immune system</subject><subject>immune-related gene</subject><subject>immunogenetics</subject><subject>landscape genomics</subject><subject>Major Histocompatibility Complex</subject><subject>Marine</subject><subject>Microsatellite Repeats</subject><subject>Models, Genetic</subject><subject>pathogen-driven selection</subject><subject>Pathogens</subject><subject>Salmo salar</subject><subject>Salmo salar - genetics</subject><subject>Salmo salar - immunology</subject><subject>Salmon</subject><subject>salmonid</subject><subject>Selection, Genetic</subject><subject>Sequence Analysis, DNA</subject><subject>Signal transduction</subject><issn>0962-1083</issn><issn>1365-294X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtvEzEUhS0EoqHwF8BiAywm-Dn2VGJRopIiNWVRqiI2luO5UxzmEewZSP49nk7Jgg1Ysnzv9XeOLB-EMCVzmtbbzZzyXGasEF_mjKQpEVLx-e4Bmh0uHqIZKXKWUaL5EXoS44YQypmUj9FR0hS5JsUMfXsP-64t8ep8cYKjv21tHXFXYajhp-2hxDFVrvddi7cBYhwC4FSf9rVte-9wtHWT-tdX4zl2NrzBvmmGFrJwZ9L2uO6cf4oeVckbnt2fx-j6w9nnxXl28Wn5cXF6kTkpJc-qqiipU6XOdUWBOhClLa1mudJAoVwX2oKuJChnGVsrVhLHiLWQpkwKyvgxejX5bkP3Y4DYm8ZHB3V6L3RDNErkjKm0_01yzqkWVCXy5V_kphvC-FWGUaKoKGSRID1BLnQxBqjMNvjGhr2hxIypmY0ZwzFjOGZMzdylZnZJ-vzef1g3UB6Ef2JKwLsJ-OVr2P-3sVmdLcYq6bNJ72MPu4Pehu8mV1xJc3O5NKuloF9vtDKXiX8x8ZXtjL0NPprrq-TMCdW0YELw3xeTvpA</recordid><startdate>201004</startdate><enddate>201004</enddate><creator>Tonteri, A</creator><creator>Vasemagi, A</creator><creator>Lumme, J</creator><creator>Primmer, C.R</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SN</scope><scope>7SS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7T5</scope><scope>7TN</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope></search><sort><creationdate>201004</creationdate><title>Beyond MHC: signals of elevated selection pressure on Atlantic salmon (Salmo salar) immune-relevant loci</title><author>Tonteri, A ; Vasemagi, A ; Lumme, J ; Primmer, C.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5553-ff9d1c7d868f1e1ce4dada82678e1edb98ae8f5e7ca22b72d0c20aaeae8254123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Atlantic salmon</topic><topic>Brackish</topic><topic>Environment</topic><topic>Evolution, Molecular</topic><topic>Expressed Sequence Tags</topic><topic>Freshwater</topic><topic>Gene Frequency</topic><topic>Genetics, Population</topic><topic>Genomics</topic><topic>Genotype</topic><topic>Immune system</topic><topic>immune-related gene</topic><topic>immunogenetics</topic><topic>landscape genomics</topic><topic>Major Histocompatibility Complex</topic><topic>Marine</topic><topic>Microsatellite Repeats</topic><topic>Models, Genetic</topic><topic>pathogen-driven selection</topic><topic>Pathogens</topic><topic>Salmo salar</topic><topic>Salmo salar - genetics</topic><topic>Salmo salar - immunology</topic><topic>Salmon</topic><topic>salmonid</topic><topic>Selection, Genetic</topic><topic>Sequence Analysis, DNA</topic><topic>Signal transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tonteri, A</creatorcontrib><creatorcontrib>Vasemagi, A</creatorcontrib><creatorcontrib>Lumme, J</creatorcontrib><creatorcontrib>Primmer, C.R</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Oceanic Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Molecular ecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tonteri, A</au><au>Vasemagi, A</au><au>Lumme, J</au><au>Primmer, C.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beyond MHC: signals of elevated selection pressure on Atlantic salmon (Salmo salar) immune-relevant loci</atitle><jtitle>Molecular ecology</jtitle><addtitle>Mol Ecol</addtitle><date>2010-04</date><risdate>2010</risdate><volume>19</volume><issue>7</issue><spage>1273</spage><epage>1282</epage><pages>1273-1282</pages><issn>0962-1083</issn><eissn>1365-294X</eissn><abstract>Using Atlantic salmon (Salmo salar) as a model system, we investigated whether 18 microsatellites tightly linked to immune-relevant genes have experienced different selection pressures than 76 loci with no obvious association with immune function. Immune-relevant loci were identified as outliers by two outlier tests significantly more often than nonimmune linked loci (22% vs. 1.6%). In addition, the allele frequencies of immune relevant markers were more often correlated with latitude and temperature. Combined, these results support the hypothesis that immune-relevant loci more frequently exhibit footprints of selection than other loci. They also indicate that the correlation between immune-relevant loci and latitude may be due to temperature-induced differences in pathogen-driven selection or some other environmental factor correlated with latitude.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>20196809</pmid><doi>10.1111/j.1365-294X.2010.04573.x</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Atlantic salmon Brackish Environment Evolution, Molecular Expressed Sequence Tags Freshwater Gene Frequency Genetics, Population Genomics Genotype Immune system immune-related gene immunogenetics landscape genomics Major Histocompatibility Complex Marine Microsatellite Repeats Models, Genetic pathogen-driven selection Pathogens Salmo salar Salmo salar - genetics Salmo salar - immunology Salmon salmonid Selection, Genetic Sequence Analysis, DNA Signal transduction |
| title | Beyond MHC: signals of elevated selection pressure on Atlantic salmon (Salmo salar) immune-relevant loci |
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