Synthesis and Antifungal Activities of New Pyrazole Derivatives via 1,3-dipolar Cycloaddition Reaction

A series of cycloadducts--pyrazoles via 1,3-dipolar cycloaddition reactions of generated nitrilimines with N-(4-chloro-2-fluorophenyl)maleimide were described. The novel compounds synthesized were characterized by ¹H NMR, MS, and elemental analysis. The fungicidal tests showed that most of the title...

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Veröffentlicht in:	Chemical biology & drug design 2010-05, Vol.75 (5), p.489-493
Hauptverfasser:	Zhang, Chuan-Yu, Liu, Xing-Hai, Wang, Bao-Lei, Wang, Su-Hua, Li, Zheng-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3-dipolar cycloaddition 3-dipolar cycloaddition antifungal activities Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Corynespora cassiicola Crystallography, X-Ray Cyclization Microbial Sensitivity Tests Molecular Conformation pyrazole derivatives Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology Structure-Activity Relationship synthesis
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Zusammenfassung:	A series of cycloadducts--pyrazoles via 1,3-dipolar cycloaddition reactions of generated nitrilimines with N-(4-chloro-2-fluorophenyl)maleimide were described. The novel compounds synthesized were characterized by ¹H NMR, MS, and elemental analysis. The fungicidal tests showed that most of the title compounds exhibit significant fungicidal activities against Corynespora cassiicola.
ISSN:	1747-0277 1747-0285
DOI:	10.1111/j.1747-0285.2010.00948.x