Advances in the treatment of neurodegenerative disorders employing nanotechnology
Due to limitations posed by the restrictive blood–brain barrier, conventional drug delivery systems do not provide adequate cyto‐architecture restoration and connection patterns that are essential for functional recovery in neurodegenerative disorders (NDs). Nanotechnology employs engineered materia...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2010-01, Vol.1184 (1), p.154-172 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | Modi, Girish Pillay, Viness Choonara, Yahya E. |
| description | Due to limitations posed by the restrictive blood–brain barrier, conventional drug delivery systems do not provide adequate cyto‐architecture restoration and connection patterns that are essential for functional recovery in neurodegenerative disorders (NDs). Nanotechnology employs engineered materials or devices that interact with biological systems at a molecular level and could revolutionize the treatment of NDs by stimulating, responding to, and interacting with target sites to induce physiological responses while minimizing side effects. This review provides a concise discussion of the current applications of nano‐enabled drug‐delivery systems for the treatment of NDs, in particular Alzheimer's and Parkinson's diseases, and explores the future applications of nanotechnology in clinical neuroscience to develop innovative therapeutic modalities for the treatment of NDs. |
| doi_str_mv | 10.1111/j.1749-6632.2009.05108.x |
| format | Article |
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| subjects | Alzheimer Disease - drug therapy Alzheimer Disease - pathology Alzheimer's disease Biological Transport Blood-Brain Barrier Brain Diseases - pathology Cytosol - metabolism drug delivery drug targeting engineered nanomaterials Humans Liposomes - therapeutic use multifunctional nanoparticles nano-biotechnology Nanocapsules - therapeutic use nanoparticles Nanoparticles - administration & dosage Nanoparticles - therapeutic use nanoscience Nanospheres - therapeutic use nanostructured Nanotechnology Nanotechnology - methods neurobiology Neurodegenerative Diseases - classification Neurodegenerative Diseases - drug therapy neuroscience Parkinson Disease - drug therapy Parkinson Disease - pathology Parkinson's disease polymers site-specific |
| title | Advances in the treatment of neurodegenerative disorders employing nanotechnology |
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