Simple route to ferrocenylalkyl nucleobases. Antitumor activity in vivo

Ferrocenylalkyl nucleobases (1–14) were prepared via the reaction of the α‐(hydroxy)alkyl ferrocenes FcCHR(OH) (Fc = ferrocenyl; R = H, Me, Et, Ph) with thymine, cytosine, iodo‐cytosine and adenine in DMSO at 100 °C, yields being 50–80%. The antitumor activities of ferrocenylmethyl thymine (1) again...

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Veröffentlicht in:	Applied organometallic chemistry 2009-06, Vol.23 (6), p.219-224
Hauptverfasser:	Simenel, Alexander A., Morozova, Elena A., Snegur, Lubov' V., Zykova, Svetlana I., Kachala, Vadim V., Ostrovskaya, Larissa A., Bluchterova, Natalia V., Fomina, Margarita M.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenine antitumor activity cytosine ferrocene nucleobases synthesis thymine α-(hydroxy)alkylferrocenes
Online-Zugang:	Volltext
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