Calcium‐Sensing Receptors Induce Apoptosis in Rat Cardiomyocytes via the Endo(sarco)plasmic Reticulum Pathway during Hypoxia/Reoxygenation

: The calcium‐sensing receptor (CaR) is a G protein‐coupled receptor. The CaR stimulation elicits phospholipase C‐mediated inositol triphosphate formation, leading to an elevation in the level of intracellular calcium released from endoplasmic reticulum (ER). Depletion of ER Ca2+ leads to ER stress...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2010-05, Vol.106 (5), p.396-405
Hauptverfasser:	Lu, Fanghao, Tian, Zhiliang, Zhang, Weihua, Zhao, Yajun, Bai, Shuzhi, Ren, Huan, Chen, He, Yu, Xue, Wang, Jingxiao, Wang, Lina, Li, Hong, Pan, Zhenwei, Tian, Ye, Yang, Baofeng, Wang, Rui, Xu, Changqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 6 - metabolism Animals Apoptosis - physiology Biological and medical sciences Calcium - metabolism Caspase 12 - metabolism Cell Hypoxia Endoplasmic Reticulum - metabolism In Vitro Techniques JNK Mitogen-Activated Protein Kinases - metabolism Male Medical sciences Microscopy, Confocal Myocardial Reperfusion Injury - metabolism Myocytes, Cardiac - metabolism Pharmacology. Drug treatments Rats Rats, Wistar Receptors, Calcium-Sensing - metabolism
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