Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus
The majority of cell lines derived by infection of murine bone marrow cells with Abelson murine leukemia virus (A-MuLV) synthesize a μ chain but no detectable light chain. Aside from this μ-only phenotype, lines that make only light chain, both chains or no immunoglobulin-related polypeptides have a...
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| Veröffentlicht in: | Cell 1979-02, Vol.16 (2), p.389-396 |
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| creator | Siden, Edward J. Baltimore, David Clark, Daniel Rosenberg, Naomi E. |
| description | The majority of cell lines derived by infection of murine bone marrow cells with Abelson murine leukemia virus (A-MuLV) synthesize a μ chain but no detectable light chain. Aside from this μ-only phenotype, lines that make only light chain, both chains or no immunoglobulin-related polypeptides have also been found. Two lines have been studied in detail: one that makes only μ chain and one that makes only κ light chain. Synthesis of both polypeptides can be increased by modifying the culture conditions so as to decrease the growth rate of the cells. Although some κ chain secretion was observed, neither secreted nor surface μ was detected. We suggest that the μ-only phenotype may be an early normal step in the pathway of B lymphocyte maturation. |
| doi_str_mv | 10.1016/0092-8674(79)90014-X |
| format | Article |
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Aside from this μ-only phenotype, lines that make only light chain, both chains or no immunoglobulin-related polypeptides have also been found. Two lines have been studied in detail: one that makes only μ chain and one that makes only κ light chain. Synthesis of both polypeptides can be increased by modifying the culture conditions so as to decrease the growth rate of the cells. Although some κ chain secretion was observed, neither secreted nor surface μ was detected. We suggest that the μ-only phenotype may be an early normal step in the pathway of B lymphocyte maturation.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/0092-8674(79)90014-X</identifier><identifier>PMID: 222460</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Carbohydrates - analysis ; Cell Line ; Cell Transformation, Neoplastic - metabolism ; Cell Transformation, Viral ; Clone Cells - metabolism ; Culture Media ; Immunoglobulin Heavy Chains - biosynthesis ; Immunoglobulin Light Chains - biosynthesis ; Immunoglobulin mu-Chains - analysis ; Immunoglobulin mu-Chains - biosynthesis ; Leukemia Virus, Murine ; Mice</subject><ispartof>Cell, 1979-02, Vol.16 (2), p.389-396</ispartof><rights>1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c271t-866f8c75efb5eecdad7c3910d76dedd32a9a61779d51375115ad8f560761761d3</citedby><cites>FETCH-LOGICAL-c271t-866f8c75efb5eecdad7c3910d76dedd32a9a61779d51375115ad8f560761761d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0092-8674(79)90014-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/222460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siden, Edward J.</creatorcontrib><creatorcontrib>Baltimore, David</creatorcontrib><creatorcontrib>Clark, Daniel</creatorcontrib><creatorcontrib>Rosenberg, Naomi E.</creatorcontrib><title>Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus</title><title>Cell</title><addtitle>Cell</addtitle><description>The majority of cell lines derived by infection of murine bone marrow cells with Abelson murine leukemia virus (A-MuLV) synthesize a μ chain but no detectable light chain. 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We suggest that the μ-only phenotype may be an early normal step in the pathway of B lymphocyte maturation.</description><subject>Animals</subject><subject>Carbohydrates - analysis</subject><subject>Cell Line</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Cell Transformation, Viral</subject><subject>Clone Cells - metabolism</subject><subject>Culture Media</subject><subject>Immunoglobulin Heavy Chains - biosynthesis</subject><subject>Immunoglobulin Light Chains - biosynthesis</subject><subject>Immunoglobulin mu-Chains - analysis</subject><subject>Immunoglobulin mu-Chains - biosynthesis</subject><subject>Leukemia Virus, Murine</subject><subject>Mice</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS3EqxT-oIusECwCthvbzQapqnhUqsQGpO6MY0-oIYmLnVTq3-PQqktWI82cezU6CI0IviOY8HuMc5pOuMhuRH6bY0yydHmEBgTnIs2IoMdocEDO0UUIXxjjCWPsDJ1SSjOOB-hjXtdd4z4rV3SVbZKwbdoVBBuSYptU23q9ctYkGqoqJK1XTSidr8EkEd3Y1rsemxZQBdckdedtA0kF3TfUVkXAd-ESnZSqCnC1n0P0_vT4NntJF6_P89l0kWoqSBt_5OVECwZlwQC0UUbocU6wEdyAMWOqcsWJELlhZCwYIUyZSck4FnHLiRkP0fWud-3dTwehlbUN_d-qAdcFKTJOKWEigtkO1N6F4KGUa29r5beSYNl7lb002UuTIpd_XuUyxkb7_q6IAg6hnch4ftidowrYWPAyaAuNBmM96FYaZ__v_wUqj4k1</recordid><startdate>197902</startdate><enddate>197902</enddate><creator>Siden, Edward J.</creator><creator>Baltimore, David</creator><creator>Clark, Daniel</creator><creator>Rosenberg, Naomi E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197902</creationdate><title>Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus</title><author>Siden, Edward J. ; Baltimore, David ; Clark, Daniel ; Rosenberg, Naomi E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c271t-866f8c75efb5eecdad7c3910d76dedd32a9a61779d51375115ad8f560761761d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Carbohydrates - analysis</topic><topic>Cell Line</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Cell Transformation, Viral</topic><topic>Clone Cells - metabolism</topic><topic>Culture Media</topic><topic>Immunoglobulin Heavy Chains - biosynthesis</topic><topic>Immunoglobulin Light Chains - biosynthesis</topic><topic>Immunoglobulin mu-Chains - analysis</topic><topic>Immunoglobulin mu-Chains - biosynthesis</topic><topic>Leukemia Virus, Murine</topic><topic>Mice</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siden, Edward J.</creatorcontrib><creatorcontrib>Baltimore, David</creatorcontrib><creatorcontrib>Clark, Daniel</creatorcontrib><creatorcontrib>Rosenberg, Naomi E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siden, Edward J.</au><au>Baltimore, David</au><au>Clark, Daniel</au><au>Rosenberg, Naomi E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1979-02</date><risdate>1979</risdate><volume>16</volume><issue>2</issue><spage>389</spage><epage>396</epage><pages>389-396</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>The majority of cell lines derived by infection of murine bone marrow cells with Abelson murine leukemia virus (A-MuLV) synthesize a μ chain but no detectable light chain. 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| ispartof | Cell, 1979-02, Vol.16 (2), p.389-396 |
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| subjects | Animals Carbohydrates - analysis Cell Line Cell Transformation, Neoplastic - metabolism Cell Transformation, Viral Clone Cells - metabolism Culture Media Immunoglobulin Heavy Chains - biosynthesis Immunoglobulin Light Chains - biosynthesis Immunoglobulin mu-Chains - analysis Immunoglobulin mu-Chains - biosynthesis Leukemia Virus, Murine Mice |
| title | Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus |
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