Memantine versus donepezil in mild to moderate Alzheimer's disease: a randomized trial with magnetic resonance spectroscopy

Background and purpose: To compare memantine with the most prescribed cholinesterase inhibitor (donepezil) from a clinical viewpoint when administered in early phases of Alzheimer disease (AD), and to find out whether memantine may produce changes in brain metabolite concentrations in comparison wi...

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Veröffentlicht in:	European journal of neurology 2010-03, Vol.17 (3), p.405-412
Hauptverfasser:	Modrego, P. J., Fayed, N., Errea, J. M., Rios, C., Pina, M. A., Sarasa, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer disease Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Brain - drug effects Brain - metabolism Cholinesterase Inhibitors - therapeutic use Dementia donepezil Female Humans Indans - therapeutic use magnetic resonance spectroscopy Magnetic Resonance Spectroscopy - methods Male memantine Memantine - therapeutic use Middle Aged Neuropsychological Tests Nootropic Agents - therapeutic use Piperidines - therapeutic use Protons Severity of Illness Index Spectrum analysis Treatment Outcome
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