PDZ domain protein CAL interacts with mGluR5a and modulates receptor expression

J. Neurochem. (2010) 112, 588-598. In this study, we investigated the association of metabotropic glutamate receptor subtype-5a (mGluR5a) with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL). Using glutathione-S-transferase pull-down techniques, we found that mGluR5a dire...

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Veröffentlicht in:	Journal of neurochemistry 2010-02, Vol.112 (3), p.588-598
Hauptverfasser:	Cheng, Shan, Zhang, Jiuqin, Zhu, Ping, Ma, Yanmei, Xiong, Ying, Sun, Licui, Xu, Jianguo, Zhang, Hong, He, Junqi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Animals, Newborn Biological and medical sciences Carrier Proteins - genetics Carrier Proteins - metabolism Cell receptors Cell structures and functions Cells, Cultured Cercopithecus aethiops Cerebral Cortex - cytology Cricetinae Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fundamental and applied biological sciences. Psychology Gene Expression - physiology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology GOPC Immunoprecipitation Medical sciences Membrane Proteins - genetics Membrane Proteins - metabolism mGluR Molecular and cellular biology Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Nervous system Neurology Neurons - drug effects Neurons - metabolism Neurosciences PDZ post-translational modification Protein Binding protein interaction Proteins Rats Rats, Wistar Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate - metabolism RNA, Small Interfering - pharmacology stabilization Transfection - methods ubiquitination
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