Metabolic changes during cell growth inhibition by p27 overexpression

The overexpression of p27, a cyclin-dependent kinase (CDK) inhibitor, has been shown to effectively inhibit cell growth at the G1-phase of different cell lines, potentiating a valid genetic strategy for cell proliferation control. In order to characterize the energy requirements after p27 overexpres...

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Veröffentlicht in:	Applied microbiology and biotechnology 2003-12, Vol.63 (2), p.164-173
Hauptverfasser:	CARVALHAL, A. V, MARCELINO, I, CARRONDO, M. J. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Nucleotides - metabolism Adenosine diphosphate Alkaline phosphatase Alkaline Phosphatase - secretion AMP Animals ATP Biological and medical sciences Biotechnology Cell Cycle Proteins - metabolism Cell Cycle Proteins - pharmacology Cell growth Cell proliferation Cell Survival - drug effects CHO Cells Cricetinae Culture Media Cyclin-Dependent Kinase Inhibitor p27 Cyclin-dependent kinases Energy charge Energy Metabolism - drug effects Energy requirements Fundamental and applied biological sciences. Psychology G1 Phase - drug effects Genetic engineering Genetic technics Humans Kinases Lactic acid Metabolism Methods. Procedures. Technologies Modification of gene expression level Protein biosynthesis Protein synthesis Proteins Proteins - metabolism Proteolysis Q1 Tumor Suppressor Proteins - metabolism Tumor Suppressor Proteins - pharmacology Up-Regulation
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