Pigmented ependymoma with signet‐ring cells and Rosenthal fibers: A rare variant of ependymoma
We report a rare case of ependymoma with vacuolar features, signet cells, pigmentation and numerous Rosenthal fibers arising in the fourth ventricle of a 35‐year‐old woman. The tumor was composed of cells with cytoplasmic vacuoles, signet cells and clear cells. The clear cells were compactly arrange...
Gespeichert in:
| Veröffentlicht in: | Neuropathology 2010-02, Vol.30 (1), p.71-75 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 75 |
|---|---|
| container_issue | 1 |
| container_start_page | 71 |
| container_title | Neuropathology |
| container_volume | 30 |
| creator | Ertan, Yesim Sarsık, Banu Özgiray, Erkin Kitis, Ömer Dalbastı, Tayfun Akalın, Taner |
| description | We report a rare case of ependymoma with vacuolar features, signet cells, pigmentation and numerous Rosenthal fibers arising in the fourth ventricle of a 35‐year‐old woman. The tumor was composed of cells with cytoplasmic vacuoles, signet cells and clear cells. The clear cells were compactly arranged resembling oligodendroglioma. Pseudovascular and ependymal rosettes were observed only in focal areas. Additionally, some tumor cells contained brown cytoplasmic pigment, which was histochemically compatible with lipofuscin and neuromelanin. On immunohistochemical examination, the tumor cells were positive for S100, glial fibrillary acidic protein and vimentin, and negative for synaptophysin, cytokeratin, neurofilament and HMB45. Epithelial membrane antigen staining showed dot‐like and small vesicular reactivity. The case is presented to increase familiarity with these extraordinary variants of ependymoma. |
| doi_str_mv | 10.1111/j.1440-1789.2009.01031.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_746199765</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>746199765</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4541-15944d5d0a66a700dbc91fbdae60ae17fd35f268aec80e9bff4dab669a8fd6293</originalsourceid><addsrcrecordid>eNqNkc1u1DAUhS1ERYfCKyDvWCXcO3EcmwVSVZUfqaIVomvjxNdTj_Iz2Jm2s-MReEaehIQZQXfUm2vpfufYOocxjpDjdN6scxQCMqyUzpcAOgeEAvP7J2zxd_GULUCjzmQpxDF7ntIaACu9VM_YMeoSVCHUgn27CquO-pEcpw31btcNneV3YbzhKax6Gn_9-BlDv-INtW3itnf8y5AmwY1tuQ81xfSWn_JoI_FbG4PtRz74B14v2JG3baKXh3nCrt-ffz37mF1cfvh0dnqRNaIUmGGphXClAyulrQBc3Wj0tbMkwRJW3hWlX0plqVFAuvZeOFtLqa3yTi51ccJe7303cfi-pTSaLqT507anYZtMJSRqXcny_2RRKK0RcCLVnmzikFIkbzYxdDbuDIKZizBrM-dt5rzNXIT5U4S5n6SvDo9s647cP-Eh-Ql4twfuQku7Rxubz-fXV_O1-A3XmZlW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733899101</pqid></control><display><type>article</type><title>Pigmented ependymoma with signet‐ring cells and Rosenthal fibers: A rare variant of ependymoma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ertan, Yesim ; Sarsık, Banu ; Özgiray, Erkin ; Kitis, Ömer ; Dalbastı, Tayfun ; Akalın, Taner</creator><creatorcontrib>Ertan, Yesim ; Sarsık, Banu ; Özgiray, Erkin ; Kitis, Ömer ; Dalbastı, Tayfun ; Akalın, Taner</creatorcontrib><description>We report a rare case of ependymoma with vacuolar features, signet cells, pigmentation and numerous Rosenthal fibers arising in the fourth ventricle of a 35‐year‐old woman. The tumor was composed of cells with cytoplasmic vacuoles, signet cells and clear cells. The clear cells were compactly arranged resembling oligodendroglioma. Pseudovascular and ependymal rosettes were observed only in focal areas. Additionally, some tumor cells contained brown cytoplasmic pigment, which was histochemically compatible with lipofuscin and neuromelanin. On immunohistochemical examination, the tumor cells were positive for S100, glial fibrillary acidic protein and vimentin, and negative for synaptophysin, cytokeratin, neurofilament and HMB45. Epithelial membrane antigen staining showed dot‐like and small vesicular reactivity. The case is presented to increase familiarity with these extraordinary variants of ependymoma.</description><identifier>ISSN: 0919-6544</identifier><identifier>EISSN: 1440-1789</identifier><identifier>DOI: 10.1111/j.1440-1789.2009.01031.x</identifier><identifier>PMID: 19508348</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Adult ; Brain - metabolism ; Brain - pathology ; Brain - surgery ; brain tumor ; Cerebral Ventricle Neoplasms - metabolism ; Cerebral Ventricle Neoplasms - pathology ; Cerebral Ventricle Neoplasms - surgery ; ependymoma ; Ependymoma - metabolism ; Ependymoma - pathology ; Ependymoma - surgery ; Female ; Fourth Ventricle - metabolism ; Fourth Ventricle - pathology ; Fourth Ventricle - surgery ; Humans ; Immunohistochemistry ; intracytoplasmic vacuole ; Magnetic Resonance Imaging ; Pigmentation ; Rosenthal fiber ; signet ring cell</subject><ispartof>Neuropathology, 2010-02, Vol.30 (1), p.71-75</ispartof><rights>2009 Japanese Society of Neuropathology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4541-15944d5d0a66a700dbc91fbdae60ae17fd35f268aec80e9bff4dab669a8fd6293</citedby><cites>FETCH-LOGICAL-c4541-15944d5d0a66a700dbc91fbdae60ae17fd35f268aec80e9bff4dab669a8fd6293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1789.2009.01031.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1789.2009.01031.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19508348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ertan, Yesim</creatorcontrib><creatorcontrib>Sarsık, Banu</creatorcontrib><creatorcontrib>Özgiray, Erkin</creatorcontrib><creatorcontrib>Kitis, Ömer</creatorcontrib><creatorcontrib>Dalbastı, Tayfun</creatorcontrib><creatorcontrib>Akalın, Taner</creatorcontrib><title>Pigmented ependymoma with signet‐ring cells and Rosenthal fibers: A rare variant of ependymoma</title><title>Neuropathology</title><addtitle>Neuropathology</addtitle><description>We report a rare case of ependymoma with vacuolar features, signet cells, pigmentation and numerous Rosenthal fibers arising in the fourth ventricle of a 35‐year‐old woman. The tumor was composed of cells with cytoplasmic vacuoles, signet cells and clear cells. The clear cells were compactly arranged resembling oligodendroglioma. Pseudovascular and ependymal rosettes were observed only in focal areas. Additionally, some tumor cells contained brown cytoplasmic pigment, which was histochemically compatible with lipofuscin and neuromelanin. On immunohistochemical examination, the tumor cells were positive for S100, glial fibrillary acidic protein and vimentin, and negative for synaptophysin, cytokeratin, neurofilament and HMB45. Epithelial membrane antigen staining showed dot‐like and small vesicular reactivity. The case is presented to increase familiarity with these extraordinary variants of ependymoma.</description><subject>Adult</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain - surgery</subject><subject>brain tumor</subject><subject>Cerebral Ventricle Neoplasms - metabolism</subject><subject>Cerebral Ventricle Neoplasms - pathology</subject><subject>Cerebral Ventricle Neoplasms - surgery</subject><subject>ependymoma</subject><subject>Ependymoma - metabolism</subject><subject>Ependymoma - pathology</subject><subject>Ependymoma - surgery</subject><subject>Female</subject><subject>Fourth Ventricle - metabolism</subject><subject>Fourth Ventricle - pathology</subject><subject>Fourth Ventricle - surgery</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>intracytoplasmic vacuole</subject><subject>Magnetic Resonance Imaging</subject><subject>Pigmentation</subject><subject>Rosenthal fiber</subject><subject>signet ring cell</subject><issn>0919-6544</issn><issn>1440-1789</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS1ERYfCKyDvWCXcO3EcmwVSVZUfqaIVomvjxNdTj_Iz2Jm2s-MReEaehIQZQXfUm2vpfufYOocxjpDjdN6scxQCMqyUzpcAOgeEAvP7J2zxd_GULUCjzmQpxDF7ntIaACu9VM_YMeoSVCHUgn27CquO-pEcpw31btcNneV3YbzhKax6Gn_9-BlDv-INtW3itnf8y5AmwY1tuQ81xfSWn_JoI_FbG4PtRz74B14v2JG3baKXh3nCrt-ffz37mF1cfvh0dnqRNaIUmGGphXClAyulrQBc3Wj0tbMkwRJW3hWlX0plqVFAuvZeOFtLqa3yTi51ccJe7303cfi-pTSaLqT507anYZtMJSRqXcny_2RRKK0RcCLVnmzikFIkbzYxdDbuDIKZizBrM-dt5rzNXIT5U4S5n6SvDo9s647cP-Eh-Ql4twfuQku7Rxubz-fXV_O1-A3XmZlW</recordid><startdate>201002</startdate><enddate>201002</enddate><creator>Ertan, Yesim</creator><creator>Sarsık, Banu</creator><creator>Özgiray, Erkin</creator><creator>Kitis, Ömer</creator><creator>Dalbastı, Tayfun</creator><creator>Akalın, Taner</creator><general>Blackwell Publishing Asia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201002</creationdate><title>Pigmented ependymoma with signet‐ring cells and Rosenthal fibers: A rare variant of ependymoma</title><author>Ertan, Yesim ; Sarsık, Banu ; Özgiray, Erkin ; Kitis, Ömer ; Dalbastı, Tayfun ; Akalın, Taner</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4541-15944d5d0a66a700dbc91fbdae60ae17fd35f268aec80e9bff4dab669a8fd6293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Brain - surgery</topic><topic>brain tumor</topic><topic>Cerebral Ventricle Neoplasms - metabolism</topic><topic>Cerebral Ventricle Neoplasms - pathology</topic><topic>Cerebral Ventricle Neoplasms - surgery</topic><topic>ependymoma</topic><topic>Ependymoma - metabolism</topic><topic>Ependymoma - pathology</topic><topic>Ependymoma - surgery</topic><topic>Female</topic><topic>Fourth Ventricle - metabolism</topic><topic>Fourth Ventricle - pathology</topic><topic>Fourth Ventricle - surgery</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>intracytoplasmic vacuole</topic><topic>Magnetic Resonance Imaging</topic><topic>Pigmentation</topic><topic>Rosenthal fiber</topic><topic>signet ring cell</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ertan, Yesim</creatorcontrib><creatorcontrib>Sarsık, Banu</creatorcontrib><creatorcontrib>Özgiray, Erkin</creatorcontrib><creatorcontrib>Kitis, Ömer</creatorcontrib><creatorcontrib>Dalbastı, Tayfun</creatorcontrib><creatorcontrib>Akalın, Taner</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuropathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ertan, Yesim</au><au>Sarsık, Banu</au><au>Özgiray, Erkin</au><au>Kitis, Ömer</au><au>Dalbastı, Tayfun</au><au>Akalın, Taner</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pigmented ependymoma with signet‐ring cells and Rosenthal fibers: A rare variant of ependymoma</atitle><jtitle>Neuropathology</jtitle><addtitle>Neuropathology</addtitle><date>2010-02</date><risdate>2010</risdate><volume>30</volume><issue>1</issue><spage>71</spage><epage>75</epage><pages>71-75</pages><issn>0919-6544</issn><eissn>1440-1789</eissn><abstract>We report a rare case of ependymoma with vacuolar features, signet cells, pigmentation and numerous Rosenthal fibers arising in the fourth ventricle of a 35‐year‐old woman. The tumor was composed of cells with cytoplasmic vacuoles, signet cells and clear cells. The clear cells were compactly arranged resembling oligodendroglioma. Pseudovascular and ependymal rosettes were observed only in focal areas. Additionally, some tumor cells contained brown cytoplasmic pigment, which was histochemically compatible with lipofuscin and neuromelanin. On immunohistochemical examination, the tumor cells were positive for S100, glial fibrillary acidic protein and vimentin, and negative for synaptophysin, cytokeratin, neurofilament and HMB45. Epithelial membrane antigen staining showed dot‐like and small vesicular reactivity. The case is presented to increase familiarity with these extraordinary variants of ependymoma.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>19508348</pmid><doi>10.1111/j.1440-1789.2009.01031.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0919-6544 |
| ispartof | Neuropathology, 2010-02, Vol.30 (1), p.71-75 |
| issn | 0919-6544 1440-1789 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_746199765 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Brain - metabolism Brain - pathology Brain - surgery brain tumor Cerebral Ventricle Neoplasms - metabolism Cerebral Ventricle Neoplasms - pathology Cerebral Ventricle Neoplasms - surgery ependymoma Ependymoma - metabolism Ependymoma - pathology Ependymoma - surgery Female Fourth Ventricle - metabolism Fourth Ventricle - pathology Fourth Ventricle - surgery Humans Immunohistochemistry intracytoplasmic vacuole Magnetic Resonance Imaging Pigmentation Rosenthal fiber signet ring cell |
| title | Pigmented ependymoma with signet‐ring cells and Rosenthal fibers: A rare variant of ependymoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T15%3A14%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pigmented%20ependymoma%20with%20signet%E2%80%90ring%20cells%20and%20Rosenthal%20fibers:%20A%20rare%20variant%20of%20ependymoma&rft.jtitle=Neuropathology&rft.au=Ertan,%20Yesim&rft.date=2010-02&rft.volume=30&rft.issue=1&rft.spage=71&rft.epage=75&rft.pages=71-75&rft.issn=0919-6544&rft.eissn=1440-1789&rft_id=info:doi/10.1111/j.1440-1789.2009.01031.x&rft_dat=%3Cproquest_cross%3E746199765%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733899101&rft_id=info:pmid/19508348&rfr_iscdi=true |