Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): A chiral stereoisomer of valproic acid urea derivative

Summary Purpose: The purpose of this study was to evaluate the stereoselective anticonvulsant activity, neurotoxicity, pharmacokinetics, and teratogenic potential of two stereoisomers of valnoctylurea (VCU), a central nervous system (CNS)–active urea derivative of valnoctic acid, which is a constit...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2010-03, Vol.51 (3), p.323-332
Hauptverfasser:	Shimshoni, Jakob A., Yagen, Boris, Wlodarczyk, Bogdan, Finnell, Richard H., Schurig, Volker, Bialer, Meir
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants Anticonvulsants - pharmacokinetics Anticonvulsants - pharmacology Anticonvulsants - toxicity Behavior, Animal - drug effects Biological and medical sciences Disease Models, Animal Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Electroshock - methods Female Half-Life Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Male Maximal electroshock seizure test Medical sciences Mice Nervous system (semeiology, syndromes) Neural Tube Defects - chemically induced Neurology Pentanoic Acids - pharmacokinetics Pentanoic Acids - pharmacology Pentanoic Acids - toxicity Pentylenetetrazole - pharmacology Pharmacokinetics Pharmacology. Drug treatments Pregnancy Rats Rats, Sprague-Dawley Seizures - chemically induced Stereoisomerism Stereoselectivity Structure-Activity Relationship Subcutaneous pentylenetetrazole seizure test Teratogenicity Teratogens - pharmacology Toxicity: cardiovascular system Urea - analogs & derivatives Urea - pharmacokinetics Urea - pharmacology Urea - toxicity Valproic Acid - analogs & derivatives Valproic Acid - pharmacokinetics Valproic Acid - pharmacology
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