Fenofibrate-Induced Muscular Toxicity Is Associated with a Metabolic Shift Limited to Type-1 Muscles in Rats

Morphological changes and mRNA expression levels in type-1 predominant soleus and type-2 predominant tensor fasciae latae muscles of rats treated with fenofibrate were investigated. After fenofibrate by oral gavage at 300 mg/kg/day for 28 days, degeneration/necrosis and regeneration of muscle fibers...

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Veröffentlicht in:	Toxicologic pathology 2009-06, Vol.37 (4), p.517-520
Hauptverfasser:	Okada, Miyoko, Sano, Fumiko, Ikeda, Itsuko, Sugimoto, Jiro, Takagi, Shiro, Sakai, Hiroki, Yanai, Tokuma
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Data Interpretation, Statistical Fenofibrate - administration & dosage Fenofibrate - toxicity Fibrosis - metabolism Gene Expression Gene Expression Profiling Glucose - metabolism Hypolipidemic Agents - administration & dosage Hypolipidemic Agents - toxicity Lipid Metabolism - genetics Male Medical sciences Muscle Fibers, Slow-Twitch - drug effects Muscle Fibers, Slow-Twitch - metabolism Muscle Fibers, Slow-Twitch - pathology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Necrosis - metabolism Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Toxicity Tests, Chronic Toxicology
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