Intralobar Nephroblastematosis in a Nine-week-old Wistar Rat
Intralobar nephroblastematosis (ILNB) is a precursor lesion to the development of nephroblastoma (NB) in rats. Unilateral ILNB was observed in the kidney of a nine-week-old female Wistar rat (Crl:WI) from a short-term toxicity study. Clinical pathology and urinalysis did not reveal altered renal fun...
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| Veröffentlicht in: | Toxicologic pathology 2009-10, Vol.37 (6), p.819-825 |
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| creator | Kalaiselvan, P. Mathur, K.Y. Pande, V.V. Madheswaran, R. Bhelonde, J.J. Shelar, P.D. Udupa, V. Shingatgeri, V.M. |
| description | Intralobar nephroblastematosis (ILNB) is a precursor lesion to the development of nephroblastoma (NB) in rats. Unilateral ILNB was observed in the kidney of a nine-week-old female Wistar rat (Crl:WI) from a short-term toxicity study. Clinical pathology and urinalysis did not reveal altered renal function. This microscopic, unencapsulated lesion consisted of basophilic sheets of blastemal cells that did not include a prominent mesenchymal component. These cells expanded in the interstitium, which trapped and compressed few normal renal tubules. The blastemal cells moderately differentiated to form rosettes, primitive tubules, and a glomeruloid body. Multifocally, the lumen of primitive tubules contained eosinophilic secretions with basophilic material in the center. The diagnostic criteria used were compared and differentiated with renal dysplasia, nephrogenic rest, NB in rats, and with that of the identical lesion in children. |
| doi_str_mv | 10.1177/0192623309343776 |
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Unilateral ILNB was observed in the kidney of a nine-week-old female Wistar rat (Crl:WI) from a short-term toxicity study. Clinical pathology and urinalysis did not reveal altered renal function. This microscopic, unencapsulated lesion consisted of basophilic sheets of blastemal cells that did not include a prominent mesenchymal component. These cells expanded in the interstitium, which trapped and compressed few normal renal tubules. The blastemal cells moderately differentiated to form rosettes, primitive tubules, and a glomeruloid body. Multifocally, the lumen of primitive tubules contained eosinophilic secretions with basophilic material in the center. The diagnostic criteria used were compared and differentiated with renal dysplasia, nephrogenic rest, NB in rats, and with that of the identical lesion in children.</description><identifier>ISSN: 0192-6233</identifier><identifier>EISSN: 1533-1601</identifier><identifier>DOI: 10.1177/0192623309343776</identifier><identifier>PMID: 19773594</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Biological and medical sciences ; Female ; Histocytochemistry ; Kidney Neoplasms - metabolism ; Kidney Neoplasms - pathology ; Kidney Neoplasms - veterinary ; Kidneys ; Medical sciences ; Nephrology. 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Unilateral ILNB was observed in the kidney of a nine-week-old female Wistar rat (Crl:WI) from a short-term toxicity study. Clinical pathology and urinalysis did not reveal altered renal function. This microscopic, unencapsulated lesion consisted of basophilic sheets of blastemal cells that did not include a prominent mesenchymal component. These cells expanded in the interstitium, which trapped and compressed few normal renal tubules. The blastemal cells moderately differentiated to form rosettes, primitive tubules, and a glomeruloid body. Multifocally, the lumen of primitive tubules contained eosinophilic secretions with basophilic material in the center. The diagnostic criteria used were compared and differentiated with renal dysplasia, nephrogenic rest, NB in rats, and with that of the identical lesion in children.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Histocytochemistry</subject><subject>Kidney Neoplasms - metabolism</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - veterinary</subject><subject>Kidneys</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Precancerous Conditions - pathology</subject><subject>Precancerous Conditions - veterinary</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Toxicology</subject><subject>Tumors of the urinary system</subject><subject>Wilms Tumor - pathology</subject><subject>Wilms Tumor - veterinary</subject><issn>0192-6233</issn><issn>1533-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLxDAUhYMozji6dyXdiKtoXk0acCODjwEZQRSXJc1DO7bNmLSI_94MUxQE7-Lexfnu6wBwjNE5xkJcICwJJ5QiSRkVgu-AKc4phZgjvAumGxlu9Ak4iHGFEC4wQ_tggqUQNJdsCi4XXR9U4ysVsqVdvwVfNSr2tlW9j3XM6i5T2bLuLPy09h36xmQvdewT_aj6Q7DnVBPt0Vhn4Pnm-ml-B-8fbhfzq3uoc8R7WFREFkwzJpwoCHIFTYdhJ7kR3GhDhMOV1ZQZipVMiWFBXIUMMoZSVhA6A2fbuevgPwYb-7Kto7ZNozrrh1gKxtNHLBeJRFtSBx9jsK5ch7pV4avEqNxYVv61LLWcjMOHqrXmt2H0KAGnI6CiVo0LqtN1_OEIlhylSBzcclG92nLlh9AlU_5f_A2wVX4-</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Kalaiselvan, P.</creator><creator>Mathur, K.Y.</creator><creator>Pande, V.V.</creator><creator>Madheswaran, R.</creator><creator>Bhelonde, J.J.</creator><creator>Shelar, P.D.</creator><creator>Udupa, V.</creator><creator>Shingatgeri, V.M.</creator><general>SAGE Publications</general><general>Sage Publications</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20091001</creationdate><title>Intralobar Nephroblastematosis in a Nine-week-old Wistar Rat</title><author>Kalaiselvan, P. ; Mathur, K.Y. ; Pande, V.V. ; Madheswaran, R. ; Bhelonde, J.J. ; Shelar, P.D. ; Udupa, V. ; Shingatgeri, V.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-8b2984c447f7820f830191f96d76dcd27f1bec34d31a9d314172fb0d0dd334823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Histocytochemistry</topic><topic>Kidney Neoplasms - metabolism</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - veterinary</topic><topic>Kidneys</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Precancerous Conditions - pathology</topic><topic>Precancerous Conditions - veterinary</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Toxicology</topic><topic>Tumors of the urinary system</topic><topic>Wilms Tumor - pathology</topic><topic>Wilms Tumor - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalaiselvan, P.</creatorcontrib><creatorcontrib>Mathur, K.Y.</creatorcontrib><creatorcontrib>Pande, V.V.</creatorcontrib><creatorcontrib>Madheswaran, R.</creatorcontrib><creatorcontrib>Bhelonde, J.J.</creatorcontrib><creatorcontrib>Shelar, P.D.</creatorcontrib><creatorcontrib>Udupa, V.</creatorcontrib><creatorcontrib>Shingatgeri, V.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicologic pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalaiselvan, P.</au><au>Mathur, K.Y.</au><au>Pande, V.V.</au><au>Madheswaran, R.</au><au>Bhelonde, J.J.</au><au>Shelar, P.D.</au><au>Udupa, V.</au><au>Shingatgeri, V.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intralobar Nephroblastematosis in a Nine-week-old Wistar Rat</atitle><jtitle>Toxicologic pathology</jtitle><addtitle>Toxicol Pathol</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>37</volume><issue>6</issue><spage>819</spage><epage>825</epage><pages>819-825</pages><issn>0192-6233</issn><eissn>1533-1601</eissn><abstract>Intralobar nephroblastematosis (ILNB) is a precursor lesion to the development of nephroblastoma (NB) in rats. Unilateral ILNB was observed in the kidney of a nine-week-old female Wistar rat (Crl:WI) from a short-term toxicity study. Clinical pathology and urinalysis did not reveal altered renal function. This microscopic, unencapsulated lesion consisted of basophilic sheets of blastemal cells that did not include a prominent mesenchymal component. These cells expanded in the interstitium, which trapped and compressed few normal renal tubules. The blastemal cells moderately differentiated to form rosettes, primitive tubules, and a glomeruloid body. Multifocally, the lumen of primitive tubules contained eosinophilic secretions with basophilic material in the center. The diagnostic criteria used were compared and differentiated with renal dysplasia, nephrogenic rest, NB in rats, and with that of the identical lesion in children.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>19773594</pmid><doi>10.1177/0192623309343776</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Female Histocytochemistry Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kidney Neoplasms - veterinary Kidneys Medical sciences Nephrology. Urinary tract diseases Precancerous Conditions - pathology Precancerous Conditions - veterinary Rats Rats, Wistar Toxicology Tumors of the urinary system Wilms Tumor - pathology Wilms Tumor - veterinary |
| title | Intralobar Nephroblastematosis in a Nine-week-old Wistar Rat |
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