Human Brucellosis Is Characterized by an Intense Th1 Profile Associated with a Defective Monocyte Function

In animal models, a defective Th1 response appears to be critical in the pathogenesis of brucellosis, but the Th1 response in human brucellosis patients remains partially undefined. Peripheral blood from 24 brucellosis patients was studied before and 45 days after antibiotherapy. Twenty-four sex- an...

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Veröffentlicht in:	Infection and Immunity 2010-07, Vol.78 (7), p.3272-3279
Hauptverfasser:	Rodríguez-Zapata, Manuel, Matías, Marlene J, Prieto, Alfredo, Jonde, Marco A, Monserrat, Jorge, Sánchez, Lorenzo, Reyes, Eduardo, De la Hera, Antonio, Alvarez-Mon, Melchor
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Bacterial diseases Biological and medical sciences Brucellosis - immunology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Fundamental and applied biological sciences. Psychology Host Response and Inflammation Human bacterial diseases Humans Infectious diseases Interferon-gamma - blood Interleukin-10 - blood Interleukin-12 - blood Interleukin-1beta - blood Interleukin-2 - blood Interleukin-4 - blood Interleukin-6 - blood Lymphocyte Activation - immunology Male Medical sciences Microbiology Middle Aged Miscellaneous Monocytes - immunology Th1 Cells - immunology Tumor Necrosis Factor-alpha - blood Young Adult
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