Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia

Heat shock protein 90 (Hsp90) is a molecular chaperone with many oncogenic client proteins. The small-molecule Hsp90 inhibitor alvespimycin, a geldanamycin derivative, is being developed for various malignancies. This phase 1 study examined the maximum-tolerated dose (MTD), safety and pharmacokineti...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia 2010-04, Vol.24 (4), p.699-705
Hauptverfasser:	Lancet, J E, Gojo, I, Burton, M, Quinn, M, Tighe, S M, Kersey, K, Zhong, Z, Albitar, M X, Bhalla, K, Hannah, A L, Baer, M R
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/436/108 631/45/612/1241 692/308/2779/109/1940 692/699/67/1990/283/1897 Acute myeloid leukemia Aged Aged, 80 and over Antimitotic agents Antineoplastic agents Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects Benzoquinones - administration & dosage Biological and medical sciences Blast Crisis Calcium-binding protein Cancer Research Critical Care Medicine Diarrhea Dosage and administration Female Fever Geldanamycin Health aspects Heat shock proteins Hematologic and hematopoietic diseases Hematology HSP70 Heat-Shock Proteins - antagonists & inhibitors HSP70 Heat-Shock Proteins - metabolism Hsp70 protein HSP90 Heat-Shock Proteins - antagonists & inhibitors Hsp90 protein Humans Infusions, Intravenous Inhibitors Intensive Internal Medicine Intravenous administration Lactams, Macrocyclic - administration & dosage Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Maximum Tolerated Dose Medical sciences Medicine Medicine & Public Health Middle Aged Myocardial infarction Nausea Neutropenia Oncology original-article Patients Pharmacodynamics Pharmacokinetics Pharmacology Remission Survival Rate Toxicity Treatment Outcome Troponin Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!