Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias

Aurora kinases are a family of protein kinases that have a key role in multiple stages of mitosis. Over-expression of Aurora kinases, particularly Aurora A, has been demonstrated in a number of solid tumors and hematological malignancies. Not surprisingly, these serine/threonine kinases have become...

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Veröffentlicht in:	Leukemia 2010-04, Vol.24 (4), p.671-678
Hauptverfasser:	Moore, A S, Blagg, J, Linardopoulos, S, Pearson, A D J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/602 631/92/436/108 692/699/67/1990/283/1896 692/699/67/1990/283/1897 Acute lymphoblastic leukemia Acute myeloid leukemia Apoptosis Aurora B protein Aurora kinase Aurora Kinase B Aurora Kinases Biological and medical sciences Cancer Research Cell division Chemical compounds Chromosome aberrations Chromosomes Chronic myeloid leukemia Clinical trials Critical Care Medicine Enzyme inhibitors Health aspects Hematologic and hematopoietic diseases Hematology Humans Imatinib Inhibitors Intensive Internal Medicine Janus kinase 2 Kinases Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - enzymology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Localization Lymphatic leukemia Medical genetics Medical prognosis Medical research Medical sciences Medicine Medicine & Public Health Mitosis Mutation Oncology Overexpression Pediatrics Pharmacology Philadelphia chromosome Phosphorylation Protein kinase Protein Kinase Inhibitors - therapeutic use Protein-Serine-Threonine Kinases - antagonists & inhibitors Proteins review Solid tumors Threonine Tumors
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