The role of salivary histatin and the human cathelicidin LL-37 in wound healing and innate immunity

Antimicrobial peptides are multifunctional in innate immunity and wound repair of multicellular organisms. We were the first to discover that histatins, a family of salivary antimicrobial peptides, enhance epithelial cell migration, suggesting a role in oral wound healing. It is unknown whether hist...

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Veröffentlicht in:	Biological chemistry 2010-05, Vol.391 (5), p.541-548, Article 541
Hauptverfasser:	Oudhoff, Menno J., Blaauboer, Marjolein E., Nazmi, Kamran, Scheres, Nina, Bolscher, Jan G.M., Veerman, Enno C.I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antifungal Agents - pharmacology Antimicrobial Cationic Peptides - physiology antimicrobial peptides Candida albicans Candida albicans - drug effects Cathelicidins Cell Death - drug effects Cell Differentiation - drug effects cell migration Cell Movement - drug effects Fibroblasts - drug effects fibrosis Fibrosis - drug therapy Gingiva - cytology gingival fibroblasts Histatins - physiology Humans Immunity, Innate - drug effects Immunity, Innate - physiology Interleukin-8 - biosynthesis Lipopolysaccharides - pharmacology Molecular Sequence Data saliva Wound Healing - drug effects Wound Healing - physiology
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