Comparative efficacy of dermal fibroblast-mediated and direct adenoviral bone morphogenetic protein-2 gene therapy for bone regeneration in an equine rib model

Cell-mediated and direct adenoviral (Ad) vector gene therapies can induce bone regeneration, including dermal fibroblasts (DFbs). We compared two effective therapies, DFb-mediated and direct Ad vector delivery of bone morphogenetic protein-2 (BMP2), for relative efficacy in bone regeneration. Equine...

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Veröffentlicht in:	Gene therapy 2010-06, Vol.17 (6), p.733-744
Hauptverfasser:	Ishihara, A, Zekas, L J, Weisbrode, S E, Bertone, A L
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/596/2561 631/532/489 631/61/201 631/61/2300 Adenoviridae Animals Biomedical and Life Sciences Biomedicine Bone density Bone diseases Bone growth Bone healing Bone mineral density Bone morphogenetic protein 2 Bone Morphogenetic Protein 2 - genetics Bone morphogenetic proteins Bone regeneration Bone Regeneration - genetics Bone turnover Bones Cancellous bone Care and treatment Cell Biology Cellular biology Cortical bone Fibroblasts Fibroblasts - transplantation Gene Expression Gene Therapy Gene transfer Gene Transfer Techniques Genetic aspects Genetic Therapy - methods Genetic Vectors Health aspects Horses Human Genetics Nanotechnology original-article Osteogenesis Osteogenesis - genetics Proteins Regeneration Rib Ribs - injuries Skin - cytology Transduction, Genetic Transplantation Viruses
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