NMDA receptor antagonist memantine promotes cell proliferation and production of mature granule neurons in the adult hippocampus

Memantine, which is used clinically for the treatment of Alzheimer's disease (AD), is classified as an N-methyl- d-aspartate (NMDA) receptor antagonist. Since previous studies have shown that NMDA receptor antagonists promote neurogenesis in the adult brain, we examined the effect of memantine...

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Veröffentlicht in:	Neuroscience research 2009-04, Vol.63 (4), p.259-266
Hauptverfasser:	Maekawa, Motoko, Namba, Takashi, Suzuki, Eri, Yuasa, Shigeki, Kohsaka, Shinichi, Uchino, Shigeo
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals BrdU Bromodeoxyuridine - metabolism Cell Count Cell Proliferation - drug effects Dose-Response Relationship, Drug Hippocampus Hippocampus - cytology Hippocampus - drug effects Homeodomain Proteins - metabolism Male Memantine - pharmacology Mice Mice, Inbred C57BL Nerve Tissue Proteins - metabolism Neural Cell Adhesion Molecule L1 - metabolism Neurogenesis Neurogenesis - drug effects Neurons - cytology Neurons - physiology NMDA receptor antagonist Progenitor cells Proliferation Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Sialic Acids - metabolism Time Factors Tumor Suppressor Proteins - metabolism
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