Sinomenine pretreatment attenuates cold ischemia/reperfusion injury in rats: The role of heme oxygenase-1
Ischemia/reperfusion (I/R) injury can be characterized as an inflammatory response including recruitment of inflammatory cells to a post-ischemic organ or tissue and a cascade of mediators. Sinomenine (SIN), a pure alkaloid extracted from the Chinese medical plant Sinomenium acutum, has been used to...
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| Veröffentlicht in: | International immunopharmacology 2010-06, Vol.10 (6), p.679-684 |
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| creator | Song, Shaohua Shen, Xiaoyun Tang, Yi Wang, Zhengxin Guo, Wenyuan Ding, Guoshan Wang, Quanxing Fu, Zhiren |
| description | Ischemia/reperfusion (I/R) injury can be characterized as an inflammatory response including recruitment of inflammatory cells to a post-ischemic organ or tissue and a cascade of mediators. Sinomenine (SIN), a pure alkaloid extracted from the Chinese medical plant
Sinomenium acutum, has been used to treat various inflammatory diseases including rheumatism and arthritis. However, whether SIN can attenuate I/R injury has not previously been examined. Using a syngeneic orthotopic liver transplantation model in rats, we investigated the effect of SIN on hepatic I/R injury, in particular its effect on heme oxygenase-1 (HO-1) induction and its hepatocellular protective effect. To our knowledge, our results were the first to show that: (a) SIN pretreatment was able to induce HO-1 expression in donor livers in a dose dependent manner; (b) SIN pretreatment protected the liver graft from cold I/R injury; and (c) the protective effect of SIN was, at least in part, mediated by HO-1, as proved by the fact that inhibiting HO-1 activity with zinc protoporphyrin (ZnPP) reduced the protection. Thus, SIN deserves further exploration as a novel agent to attenuate I/R injury. |
| doi_str_mv | 10.1016/j.intimp.2010.03.011 |
| format | Article |
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Sinomenium acutum, has been used to treat various inflammatory diseases including rheumatism and arthritis. However, whether SIN can attenuate I/R injury has not previously been examined. Using a syngeneic orthotopic liver transplantation model in rats, we investigated the effect of SIN on hepatic I/R injury, in particular its effect on heme oxygenase-1 (HO-1) induction and its hepatocellular protective effect. To our knowledge, our results were the first to show that: (a) SIN pretreatment was able to induce HO-1 expression in donor livers in a dose dependent manner; (b) SIN pretreatment protected the liver graft from cold I/R injury; and (c) the protective effect of SIN was, at least in part, mediated by HO-1, as proved by the fact that inhibiting HO-1 activity with zinc protoporphyrin (ZnPP) reduced the protection. Thus, SIN deserves further exploration as a novel agent to attenuate I/R injury.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2010.03.011</identifier><identifier>PMID: 20353835</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Apoptosis ; Biological and medical sciences ; Cold Ischemia ; Heme Oxygenase (Decyclizing) - analysis ; Heme Oxygenase (Decyclizing) - metabolism ; Heme oxygenase-1 ; Inflammation ; Kupffer cells ; Liver - enzymology ; Liver Transplantation - immunology ; Liver Transplantation - pathology ; Male ; Medical sciences ; Morphinans - administration & dosage ; Neutrophils ; Pharmacology. Drug treatments ; Protoporphyrins - adverse effects ; Rats ; Rats, Sprague-Dawley ; Reperfusion injury ; Reperfusion Injury - drug therapy ; Reperfusion Injury - enzymology ; Sinomenine ; Sinomenium acutum</subject><ispartof>International immunopharmacology, 2010-06, Vol.10 (6), p.679-684</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-cf1c8bfc0c5a5769b3594612d676a2a65914f92b727b92745a7872b321ab91b33</citedby><cites>FETCH-LOGICAL-c423t-cf1c8bfc0c5a5769b3594612d676a2a65914f92b727b92745a7872b321ab91b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2010.03.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22818298$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20353835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Shaohua</creatorcontrib><creatorcontrib>Shen, Xiaoyun</creatorcontrib><creatorcontrib>Tang, Yi</creatorcontrib><creatorcontrib>Wang, Zhengxin</creatorcontrib><creatorcontrib>Guo, Wenyuan</creatorcontrib><creatorcontrib>Ding, Guoshan</creatorcontrib><creatorcontrib>Wang, Quanxing</creatorcontrib><creatorcontrib>Fu, Zhiren</creatorcontrib><title>Sinomenine pretreatment attenuates cold ischemia/reperfusion injury in rats: The role of heme oxygenase-1</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>Ischemia/reperfusion (I/R) injury can be characterized as an inflammatory response including recruitment of inflammatory cells to a post-ischemic organ or tissue and a cascade of mediators. Sinomenine (SIN), a pure alkaloid extracted from the Chinese medical plant
Sinomenium acutum, has been used to treat various inflammatory diseases including rheumatism and arthritis. However, whether SIN can attenuate I/R injury has not previously been examined. Using a syngeneic orthotopic liver transplantation model in rats, we investigated the effect of SIN on hepatic I/R injury, in particular its effect on heme oxygenase-1 (HO-1) induction and its hepatocellular protective effect. To our knowledge, our results were the first to show that: (a) SIN pretreatment was able to induce HO-1 expression in donor livers in a dose dependent manner; (b) SIN pretreatment protected the liver graft from cold I/R injury; and (c) the protective effect of SIN was, at least in part, mediated by HO-1, as proved by the fact that inhibiting HO-1 activity with zinc protoporphyrin (ZnPP) reduced the protection. Thus, SIN deserves further exploration as a novel agent to attenuate I/R injury.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Cold Ischemia</subject><subject>Heme Oxygenase (Decyclizing) - analysis</subject><subject>Heme Oxygenase (Decyclizing) - metabolism</subject><subject>Heme oxygenase-1</subject><subject>Inflammation</subject><subject>Kupffer cells</subject><subject>Liver - enzymology</subject><subject>Liver Transplantation - immunology</subject><subject>Liver Transplantation - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Morphinans - administration & dosage</subject><subject>Neutrophils</subject><subject>Pharmacology. Drug treatments</subject><subject>Protoporphyrins - adverse effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reperfusion injury</subject><subject>Reperfusion Injury - drug therapy</subject><subject>Reperfusion Injury - enzymology</subject><subject>Sinomenine</subject><subject>Sinomenium acutum</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2LFDEQhoMo7rr6D0RyEU89m49O0u1BkMUvWPDgeg7V6Wo3Q3fSJmlx_r0ZZtSbeHqT4qmql3oJec7ZjjOur_c7H4pf1p1gtcTkjnH-gFzyznQNN0w9rG-lTaOM7i_Ik5z3jNV6yx-TC8Gkkp1Ul8R_8SEuGHxAuiYsCaHUb6FQCoYNCmbq4jxSn909Lh6uE66Ypi37GKgP-y0dqtAEJb-md_dIU5yRxolWuurPwzcMkLHhT8mjCeaMz856Rb6-f3d387G5_fzh083b28a1QpbGTdx1w-SYU3C0PkjVt5qLURsNArTqeTv1YjDCDL0wrQLTGTFIwWHo-SDlFXl1mrum-H3DXOxSveM8Q8C4ZWvqNKWY-g9SSsl6rVkl2xPpUsw54WTX5BdIB8uZPaZh9_aUhj2mYZm0NY3a9uK8YBsWHP80_T5_BV6eAcgO5ilBcD7_5UTHO9F3lXtz4rAe7ofHZLPzGByOPqErdoz-305-AVzfqlE</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Song, Shaohua</creator><creator>Shen, Xiaoyun</creator><creator>Tang, Yi</creator><creator>Wang, Zhengxin</creator><creator>Guo, Wenyuan</creator><creator>Ding, Guoshan</creator><creator>Wang, Quanxing</creator><creator>Fu, Zhiren</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20100601</creationdate><title>Sinomenine pretreatment attenuates cold ischemia/reperfusion injury in rats: The role of heme oxygenase-1</title><author>Song, Shaohua ; Shen, Xiaoyun ; Tang, Yi ; Wang, Zhengxin ; Guo, Wenyuan ; Ding, Guoshan ; Wang, Quanxing ; Fu, Zhiren</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-cf1c8bfc0c5a5769b3594612d676a2a65914f92b727b92745a7872b321ab91b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Cold Ischemia</topic><topic>Heme Oxygenase (Decyclizing) - analysis</topic><topic>Heme Oxygenase (Decyclizing) - metabolism</topic><topic>Heme oxygenase-1</topic><topic>Inflammation</topic><topic>Kupffer cells</topic><topic>Liver - enzymology</topic><topic>Liver Transplantation - immunology</topic><topic>Liver Transplantation - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Morphinans - administration & dosage</topic><topic>Neutrophils</topic><topic>Pharmacology. Drug treatments</topic><topic>Protoporphyrins - adverse effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reperfusion injury</topic><topic>Reperfusion Injury - drug therapy</topic><topic>Reperfusion Injury - enzymology</topic><topic>Sinomenine</topic><topic>Sinomenium acutum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Shaohua</creatorcontrib><creatorcontrib>Shen, Xiaoyun</creatorcontrib><creatorcontrib>Tang, Yi</creatorcontrib><creatorcontrib>Wang, Zhengxin</creatorcontrib><creatorcontrib>Guo, Wenyuan</creatorcontrib><creatorcontrib>Ding, Guoshan</creatorcontrib><creatorcontrib>Wang, Quanxing</creatorcontrib><creatorcontrib>Fu, Zhiren</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Shaohua</au><au>Shen, Xiaoyun</au><au>Tang, Yi</au><au>Wang, Zhengxin</au><au>Guo, Wenyuan</au><au>Ding, Guoshan</au><au>Wang, Quanxing</au><au>Fu, Zhiren</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sinomenine pretreatment attenuates cold ischemia/reperfusion injury in rats: The role of heme oxygenase-1</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>10</volume><issue>6</issue><spage>679</spage><epage>684</epage><pages>679-684</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>Ischemia/reperfusion (I/R) injury can be characterized as an inflammatory response including recruitment of inflammatory cells to a post-ischemic organ or tissue and a cascade of mediators. Sinomenine (SIN), a pure alkaloid extracted from the Chinese medical plant
Sinomenium acutum, has been used to treat various inflammatory diseases including rheumatism and arthritis. However, whether SIN can attenuate I/R injury has not previously been examined. Using a syngeneic orthotopic liver transplantation model in rats, we investigated the effect of SIN on hepatic I/R injury, in particular its effect on heme oxygenase-1 (HO-1) induction and its hepatocellular protective effect. To our knowledge, our results were the first to show that: (a) SIN pretreatment was able to induce HO-1 expression in donor livers in a dose dependent manner; (b) SIN pretreatment protected the liver graft from cold I/R injury; and (c) the protective effect of SIN was, at least in part, mediated by HO-1, as proved by the fact that inhibiting HO-1 activity with zinc protoporphyrin (ZnPP) reduced the protection. Thus, SIN deserves further exploration as a novel agent to attenuate I/R injury.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>20353835</pmid><doi>10.1016/j.intimp.2010.03.011</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Apoptosis Biological and medical sciences Cold Ischemia Heme Oxygenase (Decyclizing) - analysis Heme Oxygenase (Decyclizing) - metabolism Heme oxygenase-1 Inflammation Kupffer cells Liver - enzymology Liver Transplantation - immunology Liver Transplantation - pathology Male Medical sciences Morphinans - administration & dosage Neutrophils Pharmacology. Drug treatments Protoporphyrins - adverse effects Rats Rats, Sprague-Dawley Reperfusion injury Reperfusion Injury - drug therapy Reperfusion Injury - enzymology Sinomenine Sinomenium acutum |
| title | Sinomenine pretreatment attenuates cold ischemia/reperfusion injury in rats: The role of heme oxygenase-1 |
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