A role for protein kinase PKR in the mediation of Epstein–Barr virus latent membrane protein-1-induced IL-6 and IL-10 expression

Expression of Epstein–Barr virus-encoded oncogenic latent membrane protein 1 (LMP1) has been substantially associated with tumorigenic transformation in the virus-infected cells. The pathogenic complexity of LMP1 is partly due to the cytokine dysregulation including IL-6 and IL-10 in perturbing the...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2010-05, Vol.50 (2), p.210-219
Hauptverfasser:	Lin, San San, Lee, Davy C.W., Law, Anna H.Y., Fang, Jun Wei, Chua, Daniel T.T., Lau, Allan S.Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminopurine Cell Line Cytokine EBV eIF-2 Kinase - metabolism Enzyme Activation - drug effects Epstein-Barr virus Eukaryotic Initiation Factor-2B - metabolism Histones - metabolism Humans Interleukin-10 - genetics Interleukin-10 - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Kinase LMP1 Models, Biological NF-kappa B - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation - drug effects PKR Protein Kinase Inhibitors - pharmacology Up-Regulation - drug effects Viral Matrix Proteins - metabolism
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