Changes in UNC5C Gene Methylation during Human Gastric Carcinogenesis
Background: UNC5C, one of the netrin-1 receptors, belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of their ligands. Recently, aberrant methylation of the UNC5C gene was found in 34 out of 49 (69%) primary colon carcinomas. M...
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Veröffentlicht in: | Anticancer research 2009-11, Vol.29 (11), p.4397-4400 |
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creator | Hibi, Kenji Sakata, Makiko Sakuraba, Kazuma Kitamura, Yo-Hei Shirahata, Atsushi Goto, Tetsuhiro Mizukami, Hiroki Saito, Mitsuo Ishibashi, Kazuyoshi Kigawa, Gaku Nemoto, Hiroshi Sanada, Yutaka |
description | Background: UNC5C, one of the netrin-1 receptors, belongs to the functional dependence receptor family, members of which share
the ability to induce apoptosis in the absence of their ligands. Recently, aberrant methylation of the UNC5C gene was found
in 34 out of 49 (69%) primary colon carcinomas. Materials and Methods: The methylation status of the UNC5C gene was examined
in primary carcinomas and the corresponding normal tissues derived from 36 patients with gastric cancer using quantitative
methylation-specific polymerase chain reaction, and the correlation between the methylation status and the clinicopathological
findings was evaluated. Results: Aberrant methylation of the UNC5C gene was detected in 9 out of the 36 (25%) primary gastric
carcinomas. A significant difference was observed in regard to the TNM stage (p=0.0455). Conclusion: UNC5C methylation was
observed in the course of gastric carcinogenesis and disappeared in highly advanced gastric carcinomas. |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_746152888</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>746152888</sourcerecordid><originalsourceid>FETCH-LOGICAL-h273t-4f853dadb4446c3161aab11b33e3e3935a250cd20b23d444aa98bcbb26cc39033</originalsourceid><addsrcrecordid>eNo1z19LwzAUBfAgipvTryB50qdCktt_eZQyN2Hqi3sON2nWRtp0Ji2yb29hk_twXn4czr0iS15InhQZsGuyZCJjScFYtiB3MX4zlueyhFuyEIyBgDJdknXVom9spM7T_UeVVXRjvaXvdmxPHY5u8LSegvMN3U49errBOAZnaIXBOD80M44u3pObA3bRPlxyRfav669qm-w-N2_Vyy5pRQFjkh7KDGqsdZqmuQGec0TNuQaw80nIcB5sasG0gHo2iLLURmuRGwOSAazI87n3GIafycZR9S4a23Xo7TBFVaQ5z0RZlrN8vMhJ97ZWx-B6DCf1__kMns6gdU3764JVsceumzkoDEIqzlUKsoA_iMFhSg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>746152888</pqid></control><display><type>article</type><title>Changes in UNC5C Gene Methylation during Human Gastric Carcinogenesis</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Hibi, Kenji ; Sakata, Makiko ; Sakuraba, Kazuma ; Kitamura, Yo-Hei ; Shirahata, Atsushi ; Goto, Tetsuhiro ; Mizukami, Hiroki ; Saito, Mitsuo ; Ishibashi, Kazuyoshi ; Kigawa, Gaku ; Nemoto, Hiroshi ; Sanada, Yutaka</creator><creatorcontrib>Hibi, Kenji ; Sakata, Makiko ; Sakuraba, Kazuma ; Kitamura, Yo-Hei ; Shirahata, Atsushi ; Goto, Tetsuhiro ; Mizukami, Hiroki ; Saito, Mitsuo ; Ishibashi, Kazuyoshi ; Kigawa, Gaku ; Nemoto, Hiroshi ; Sanada, Yutaka</creatorcontrib><description>Background: UNC5C, one of the netrin-1 receptors, belongs to the functional dependence receptor family, members of which share
the ability to induce apoptosis in the absence of their ligands. Recently, aberrant methylation of the UNC5C gene was found
in 34 out of 49 (69%) primary colon carcinomas. Materials and Methods: The methylation status of the UNC5C gene was examined
in primary carcinomas and the corresponding normal tissues derived from 36 patients with gastric cancer using quantitative
methylation-specific polymerase chain reaction, and the correlation between the methylation status and the clinicopathological
findings was evaluated. Results: Aberrant methylation of the UNC5C gene was detected in 9 out of the 36 (25%) primary gastric
carcinomas. A significant difference was observed in regard to the TNM stage (p=0.0455). Conclusion: UNC5C methylation was
observed in the course of gastric carcinogenesis and disappeared in highly advanced gastric carcinomas.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 20032384</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Aged ; Aged, 80 and over ; DNA Methylation ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Netrin Receptors ; Receptors, Cell Surface - genetics ; Stomach Neoplasms - genetics ; Stomach Neoplasms - pathology</subject><ispartof>Anticancer research, 2009-11, Vol.29 (11), p.4397-4400</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20032384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hibi, Kenji</creatorcontrib><creatorcontrib>Sakata, Makiko</creatorcontrib><creatorcontrib>Sakuraba, Kazuma</creatorcontrib><creatorcontrib>Kitamura, Yo-Hei</creatorcontrib><creatorcontrib>Shirahata, Atsushi</creatorcontrib><creatorcontrib>Goto, Tetsuhiro</creatorcontrib><creatorcontrib>Mizukami, Hiroki</creatorcontrib><creatorcontrib>Saito, Mitsuo</creatorcontrib><creatorcontrib>Ishibashi, Kazuyoshi</creatorcontrib><creatorcontrib>Kigawa, Gaku</creatorcontrib><creatorcontrib>Nemoto, Hiroshi</creatorcontrib><creatorcontrib>Sanada, Yutaka</creatorcontrib><title>Changes in UNC5C Gene Methylation during Human Gastric Carcinogenesis</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: UNC5C, one of the netrin-1 receptors, belongs to the functional dependence receptor family, members of which share
the ability to induce apoptosis in the absence of their ligands. Recently, aberrant methylation of the UNC5C gene was found
in 34 out of 49 (69%) primary colon carcinomas. Materials and Methods: The methylation status of the UNC5C gene was examined
in primary carcinomas and the corresponding normal tissues derived from 36 patients with gastric cancer using quantitative
methylation-specific polymerase chain reaction, and the correlation between the methylation status and the clinicopathological
findings was evaluated. Results: Aberrant methylation of the UNC5C gene was detected in 9 out of the 36 (25%) primary gastric
carcinomas. A significant difference was observed in regard to the TNM stage (p=0.0455). Conclusion: UNC5C methylation was
observed in the course of gastric carcinogenesis and disappeared in highly advanced gastric carcinomas.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>DNA Methylation</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Netrin Receptors</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - pathology</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1z19LwzAUBfAgipvTryB50qdCktt_eZQyN2Hqi3sON2nWRtp0Ji2yb29hk_twXn4czr0iS15InhQZsGuyZCJjScFYtiB3MX4zlueyhFuyEIyBgDJdknXVom9spM7T_UeVVXRjvaXvdmxPHY5u8LSegvMN3U49errBOAZnaIXBOD80M44u3pObA3bRPlxyRfav669qm-w-N2_Vyy5pRQFjkh7KDGqsdZqmuQGec0TNuQaw80nIcB5sasG0gHo2iLLURmuRGwOSAazI87n3GIafycZR9S4a23Xo7TBFVaQ5z0RZlrN8vMhJ97ZWx-B6DCf1__kMns6gdU3764JVsceumzkoDEIqzlUKsoA_iMFhSg</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Hibi, Kenji</creator><creator>Sakata, Makiko</creator><creator>Sakuraba, Kazuma</creator><creator>Kitamura, Yo-Hei</creator><creator>Shirahata, Atsushi</creator><creator>Goto, Tetsuhiro</creator><creator>Mizukami, Hiroki</creator><creator>Saito, Mitsuo</creator><creator>Ishibashi, Kazuyoshi</creator><creator>Kigawa, Gaku</creator><creator>Nemoto, Hiroshi</creator><creator>Sanada, Yutaka</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20091101</creationdate><title>Changes in UNC5C Gene Methylation during Human Gastric Carcinogenesis</title><author>Hibi, Kenji ; Sakata, Makiko ; Sakuraba, Kazuma ; Kitamura, Yo-Hei ; Shirahata, Atsushi ; Goto, Tetsuhiro ; Mizukami, Hiroki ; Saito, Mitsuo ; Ishibashi, Kazuyoshi ; Kigawa, Gaku ; Nemoto, Hiroshi ; Sanada, Yutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h273t-4f853dadb4446c3161aab11b33e3e3935a250cd20b23d444aa98bcbb26cc39033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>DNA Methylation</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Netrin Receptors</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hibi, Kenji</creatorcontrib><creatorcontrib>Sakata, Makiko</creatorcontrib><creatorcontrib>Sakuraba, Kazuma</creatorcontrib><creatorcontrib>Kitamura, Yo-Hei</creatorcontrib><creatorcontrib>Shirahata, Atsushi</creatorcontrib><creatorcontrib>Goto, Tetsuhiro</creatorcontrib><creatorcontrib>Mizukami, Hiroki</creatorcontrib><creatorcontrib>Saito, Mitsuo</creatorcontrib><creatorcontrib>Ishibashi, Kazuyoshi</creatorcontrib><creatorcontrib>Kigawa, Gaku</creatorcontrib><creatorcontrib>Nemoto, Hiroshi</creatorcontrib><creatorcontrib>Sanada, Yutaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hibi, Kenji</au><au>Sakata, Makiko</au><au>Sakuraba, Kazuma</au><au>Kitamura, Yo-Hei</au><au>Shirahata, Atsushi</au><au>Goto, Tetsuhiro</au><au>Mizukami, Hiroki</au><au>Saito, Mitsuo</au><au>Ishibashi, Kazuyoshi</au><au>Kigawa, Gaku</au><au>Nemoto, Hiroshi</au><au>Sanada, Yutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in UNC5C Gene Methylation during Human Gastric Carcinogenesis</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>29</volume><issue>11</issue><spage>4397</spage><epage>4400</epage><pages>4397-4400</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: UNC5C, one of the netrin-1 receptors, belongs to the functional dependence receptor family, members of which share
the ability to induce apoptosis in the absence of their ligands. Recently, aberrant methylation of the UNC5C gene was found
in 34 out of 49 (69%) primary colon carcinomas. Materials and Methods: The methylation status of the UNC5C gene was examined
in primary carcinomas and the corresponding normal tissues derived from 36 patients with gastric cancer using quantitative
methylation-specific polymerase chain reaction, and the correlation between the methylation status and the clinicopathological
findings was evaluated. Results: Aberrant methylation of the UNC5C gene was detected in 9 out of the 36 (25%) primary gastric
carcinomas. A significant difference was observed in regard to the TNM stage (p=0.0455). Conclusion: UNC5C methylation was
observed in the course of gastric carcinogenesis and disappeared in highly advanced gastric carcinomas.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>20032384</pmid><tpages>4</tpages></addata></record> |
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source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
subjects | Aged Aged, 80 and over DNA Methylation Female Humans Male Middle Aged Neoplasm Staging Netrin Receptors Receptors, Cell Surface - genetics Stomach Neoplasms - genetics Stomach Neoplasms - pathology |
title | Changes in UNC5C Gene Methylation during Human Gastric Carcinogenesis |
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