Changes in UNC5C Gene Methylation during Human Gastric Carcinogenesis

Background: UNC5C, one of the netrin-1 receptors, belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of their ligands. Recently, aberrant methylation of the UNC5C gene was found in 34 out of 49 (69%) primary colon carcinomas. M...

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Veröffentlicht in:Anticancer research 2009-11, Vol.29 (11), p.4397-4400
Hauptverfasser: Hibi, Kenji, Sakata, Makiko, Sakuraba, Kazuma, Kitamura, Yo-Hei, Shirahata, Atsushi, Goto, Tetsuhiro, Mizukami, Hiroki, Saito, Mitsuo, Ishibashi, Kazuyoshi, Kigawa, Gaku, Nemoto, Hiroshi, Sanada, Yutaka
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container_end_page 4400
container_issue 11
container_start_page 4397
container_title Anticancer research
container_volume 29
creator Hibi, Kenji
Sakata, Makiko
Sakuraba, Kazuma
Kitamura, Yo-Hei
Shirahata, Atsushi
Goto, Tetsuhiro
Mizukami, Hiroki
Saito, Mitsuo
Ishibashi, Kazuyoshi
Kigawa, Gaku
Nemoto, Hiroshi
Sanada, Yutaka
description Background: UNC5C, one of the netrin-1 receptors, belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of their ligands. Recently, aberrant methylation of the UNC5C gene was found in 34 out of 49 (69%) primary colon carcinomas. Materials and Methods: The methylation status of the UNC5C gene was examined in primary carcinomas and the corresponding normal tissues derived from 36 patients with gastric cancer using quantitative methylation-specific polymerase chain reaction, and the correlation between the methylation status and the clinicopathological findings was evaluated. Results: Aberrant methylation of the UNC5C gene was detected in 9 out of the 36 (25%) primary gastric carcinomas. A significant difference was observed in regard to the TNM stage (p=0.0455). Conclusion: UNC5C methylation was observed in the course of gastric carcinogenesis and disappeared in highly advanced gastric carcinomas.
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subjects Aged
Aged, 80 and over
DNA Methylation
Female
Humans
Male
Middle Aged
Neoplasm Staging
Netrin Receptors
Receptors, Cell Surface - genetics
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
title Changes in UNC5C Gene Methylation during Human Gastric Carcinogenesis
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