A characterization of the antioxidant enzyme activity and reproductive toxicity in male rats following sub-chronic exposure to areca nut extracts

In the present study, areca nut extracts (ANE) administered to male rats by gavage at a dose of 100 mg/kg/day for a period of 15, 30, or 45 days resulted in signs of reproductive toxicity. ANE administration resulted in a significant decline (30–57% in epididymal sperm count and 27–61% in sperm moti...

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Veröffentlicht in:	Journal of hazardous materials 2010-06, Vol.178 (1), p.541-546
Hauptverfasser:	Wu, Pei-Fen, Chiang, Tai-An, Chen, Min-Tzu, Lee, Chi-Pin, Chen, Ping-Ho, Ko, Albert Min-Shan, Yang, Kai-Jen, Chang, Po-Ya, Ke, Der-Shin, Ko, Ying-Chin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant enzyme activities Antioxidants - chemistry Applied sciences Areca - toxicity Areca nut extracts Body Weight - drug effects Catalase - metabolism Chemical engineering Epididymis - cytology Exact sciences and technology Indicators and Reagents Infertility, Male - chemically induced Infertility, Male - pathology Lipid Peroxidation - drug effects Male Male rats Malondialdehyde - metabolism Organ Size - drug effects Plant Extracts - toxicity Pollution Rats Rats, Sprague-Dawley Reactive Oxygen Species - chemistry Reactors Reproductive toxicity Sialic Acids - metabolism Sperm Count Sperm Motility - drug effects Spermatozoa - drug effects Superoxide Dismutase - metabolism Time-course study
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