Role of oxidative stress and MAPK signaling in reference moist smokeless tobacco-induced HOK-16B cell death

The use of smokeless tobacco products is often associated with an oral injury at the site of repeated use. To further our understanding of this injury process, the effect of reference moist smokeless tobacco extract (STE) on cell death, oxidative stress, and MAPK signaling in a human oral keratinocy...

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Veröffentlicht in:	Toxicology letters 2010-05, Vol.195 (1), p.23-30
Hauptverfasser:	Mitchell, Clint, Joyce, Andrew R., Piper, John T., McKallip, Robert J., Fariss, Marc W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ascorbic Acid Biological and medical sciences Cell Death - drug effects Cell Line Chemical and industrial products toxicology. Toxic occupational diseases Chromans Deferoxamine Dose-Response Relationship, Drug Gene Expression Regulation - drug effects Humans Keratinocytes - drug effects Keratinocytes - physiology MAP Kinase Signaling System - physiology MAPK pathways, Oral keratinocyte, Oxidative stress, Smokeless tobacco, Iron, Antioxidants Medical sciences Metals and various inorganic compounds Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - metabolism Oxidative Stress - drug effects Time Factors Tobacco, Smokeless - toxicity Toxicology
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