Functional role of acetylcholine and the expression of cholinergic receptors and components in osteoblasts

Recent studies have indicated that acetylcholine (ACh) plays a vital role in various tissues, while the role of ACh in bone metabolism remains unclear. Here we demonstrated that ACh induced cell proliferation and reduced alkaline phosphatase (ALP) activity via nicotinic (nAChRs) and muscarinic acety...

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Veröffentlicht in:	FEBS letters 2010-02, Vol.584 (4), p.817-824
Hauptverfasser:	Sato, Tsuyoshi, Abe, Takahiro, Chida, Dai, Nakamoto, Norimichi, Hori, Naoko, Kokabu, Shoichiro, Sakata, Yasuaki, Tomaru, Yasuhisa, Iwata, Takanori, Usui, Michihiko, Aiko, Katsuya, Yoda, Tetsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells 5-bromo-2′-deoxyuridine Acetylcholine Acetylcholine - analogs & derivatives Acetylcholine - pharmacology acetylcholinesterase Acetylcholinesterase - genetics ACh AChE alkaline phosphatase Alkaline Phosphatase - metabolism ALP Animals Atr atropine Blotting, Western BrdU carbachol CCh Cell Proliferation - drug effects Cells, Cultured ChAT choline acetyltransferase Choline O-Acetyltransferase - genetics Cholinergic Agents - pharmacology Cholinergic component Cholinergic receptor CHT1 Cyclin D1 - genetics Cyclin D1 - metabolism Differentiation Dose-Response Relationship, Drug Gene Expression Regulation - drug effects high affinity choline transporter mAChRs Mec mecamylamine Mice Mus muscarine muscarinic acetylcholine receptors nAChRs Nic nicotine nicotinic acetylcholine receptors Osteoblast Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism pOB primary osteoblasts Proliferation Receptors, Cholinergic - genetics Receptors, Cholinergic - metabolism Receptors, Muscarinic - genetics Receptors, Muscarinic - metabolism Reverse Transcriptase Polymerase Chain Reaction Symporters - genetics VAChT vasoactive intestinal peptide Vesicular Acetylcholine Transport Proteins - genetics vesicular acetylcholine transporter VIP
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