STUDIES ON THE PROGNOSIS OF ACUTE HEPATITIS IN VIEW OF CARBOHYDRATE METABORISM

We performed 100 g oral glucose tolerance test (GTT) in 194 patients with acute hepatitis, and examined serum immunoreactive insulin (IRI)in 100 subjects. We investigated the relationship between prognosis of acute hepatitis and family history of diabetes mellitus, GTT patterns and insulinogenic index (30'ΔIRI/ΔBS) The results are as follows: The acute hepatitic patients with family history of diabetes mellitus transfere more frequently into chronic hepatitis than those without family history. The prognosis of acute hepatitis is significantly better in subjects with normal GTT than those with abnormal GTT during the acute stage. In the cases whose courses were followed from acute stage to recovery stage, the prognosis are better in the patients who showed improvement in GTT than those who showed no improvement. In respect to insulinogenic index (30'ΔIRI/ΔBS), the prognosis is obviously better in the cases with 30'ΔIRI/ΔBS>=d0.8 than those dBS dBS with 30'ΔIRI/ΔBS>0.8 either in acute or recovery stage. Accordingly, we conclude that GTT in acute stage and 30'ΔIRI/ΔBS or recovery stage may be useful as indicators of prognosis of acute hepatitis.