Short Communication: Selection of Thymidine Analogue Resistance Mutational Patterns in Children Infected from a Common HIV Type 1 Subtype G Source

In HIV-1, thymidine analogue mutations (TAMs) cluster in one of two groups (215Y, 41L, 210W, or 215F, 219E/Q), representing two independent mutational patterns (T215Y and T215F cluster, respectively). The mechanisms by which these pathways are selected are not fully understood. To investigate possib...

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Veröffentlicht in:	AIDS research and human retroviruses 2010-03, Vol.26 (3), p.275-278
Hauptverfasser:	DAUMER, Martin, AWERKIEW, Sabine, PFISTER, Herbert, KAISER, Rolf, ARAGON, Saleta Sierra, KARTASHEV, Vladimir, POPLAVSKAJA, Tatjana, KLEIN, Rolf, SICHTIG, Nadine, THIELE, Bernhard, LENGAUER, Thomas, ROOMP, Kirsten
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Anti-HIV Agents - therapeutic use Care and treatment Child Drug resistance Drug Resistance, Viral - genetics Gene mutations Genetic aspects Health aspects HIV infection HIV Infections - drug therapy HIV Infections - virology HIV Reverse Transcriptase - genetics HIV-1 - drug effects HIV-1 - physiology HLA-A Antigens - genetics HLA-B Antigens - genetics HLA-DR Antigens - genetics Host-Pathogen Interactions Human immunodeficiency virus 1 Humans Molecular Sequence Data Physiological aspects Polymorphism, Single Nucleotide Retrovirus Viral Load Zidovudine Zidovudine - therapeutic use
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