Morphological findings in idiopathic calcification of the ascending aorta and aortic valve affecting a young woman
The pathology of a case of idiopathic calcification affecting the ascending aorta in a young woman is presented. A varying width of media throughout the aorta and extending into its proximal branches was devoid of cell nuclei (medial necrosis) although elastic lamellae persisted. Plaques of calcium,...
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| Veröffentlicht in: | Histopathology 1979-05, Vol.3 (3), p.181-190 |
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| container_end_page | 190 |
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| container_title | Histopathology |
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| creator | THEMAN, T. E. SILVER, M. D. HAUST, M. D. McLOUGHLIN, M. J. WIGLE, E. D. WILLIAMS, W. R. |
| description | The pathology of a case of idiopathic calcification affecting the ascending aorta in a young woman is presented. A varying width of media throughout the aorta and extending into its proximal branches was devoid of cell nuclei (medial necrosis) although elastic lamellae persisted. Plaques of calcium, found in the acellular media, were confined to the ascending aorta. No inflammatory or reparative reaction was seen in the vessel wall. Electron microscopically, the calcium seemed to have an affinity for elastic tissue elements of all sizes and the mode of deposition appeared to be by ‘avenues’ of the microfibrillar component Possible pathogenetic mechanisms are discussed. |
| doi_str_mv | 10.1111/j.1365-2559.1979.tb02995.x |
| format | Article |
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E.</creatorcontrib><creatorcontrib>SILVER, M. D.</creatorcontrib><creatorcontrib>HAUST, M. D.</creatorcontrib><creatorcontrib>McLOUGHLIN, M. J.</creatorcontrib><creatorcontrib>WIGLE, E. D.</creatorcontrib><creatorcontrib>WILLIAMS, W. R.</creatorcontrib><title>Morphological findings in idiopathic calcification of the ascending aorta and aortic valve affecting a young woman</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>The pathology of a case of idiopathic calcification affecting the ascending aorta in a young woman is presented. A varying width of media throughout the aorta and extending into its proximal branches was devoid of cell nuclei (medial necrosis) although elastic lamellae persisted. Plaques of calcium, found in the acellular media, were confined to the ascending aorta. No inflammatory or reparative reaction was seen in the vessel wall. Electron microscopically, the calcium seemed to have an affinity for elastic tissue elements of all sizes and the mode of deposition appeared to be by ‘avenues’ of the microfibrillar component Possible pathogenetic mechanisms are discussed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>aorta</subject><subject>Aorta - pathology</subject><subject>Aorta, Abdominal - surgery</subject><subject>Aorta, Thoracic - pathology</subject><subject>aortic calcification</subject><subject>Aortic Diseases - pathology</subject><subject>aortic valve calcification</subject><subject>Aortic Valve Insufficiency - pathology</subject><subject>Aortic Valve Stenosis - pathology</subject><subject>Aortic Valve Stenosis - surgery</subject><subject>Bioprosthesis</subject><subject>Blood Vessel Prosthesis</subject><subject>Calcinosis - pathology</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Heart Ventricles - surgery</subject><subject>Humans</subject><subject>medial necrosis</subject><subject>Mitral Valve - pathology</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM1uEzEUhS3EXyi8AQuLBbsZ_G8PCyRoIa3UAlJBSGwsj2M3DpNxsCdt8vZ4MlH2eHMtnc_HVx8AbzCqcTnvVjWmgleE86bGjWzqoUWkaXi9ewRmp-gxmCGKmgphIZ-DFzmvEMKSEvIMPGVCYYJnIN3EtFnGLt4FazroQ78I_V2GoYdhEeLGDMtgYYls8IUYQuxh9HBYOmiydQcampgGA02_ONwKf2-6-wJ47-xwAOA-bst8iGvTvwRPvOmye3WcZ-Dnl88_zi-r62_zq_OP15VlSOCKCkeckVZh56Xx0mNHKCOMj5sLirkTjLZeKdJKxRpOFFNGeUt86xh3lJ6Bt1PvJsW_W5cHvQ5l5a4zvYvbrCUTGFHCCvh-Am2KOSfn9SaFtUl7jZEefeuVHqXqUaoefeujb70rj18ff9m2a7c4PZ0El_jDFD-Ezu3_o1hfXt1iNRZUU0HIg9udCkz6o4WkkutfX-f6029x8X1-catv6D-0eqCp</recordid><startdate>197905</startdate><enddate>197905</enddate><creator>THEMAN, T. E.</creator><creator>SILVER, M. D.</creator><creator>HAUST, M. D.</creator><creator>McLOUGHLIN, M. J.</creator><creator>WIGLE, E. D.</creator><creator>WILLIAMS, W. R.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197905</creationdate><title>Morphological findings in idiopathic calcification of the ascending aorta and aortic valve affecting a young woman</title><author>THEMAN, T. E. ; SILVER, M. D. ; HAUST, M. D. ; McLOUGHLIN, M. J. ; WIGLE, E. D. ; WILLIAMS, W. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4061-36e2ea7c81ef7af7f1e23424568126315e643bf882b784952848a8fc2fbe45e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>aorta</topic><topic>Aorta - pathology</topic><topic>Aorta, Abdominal - surgery</topic><topic>Aorta, Thoracic - pathology</topic><topic>aortic calcification</topic><topic>Aortic Diseases - pathology</topic><topic>aortic valve calcification</topic><topic>Aortic Valve Insufficiency - pathology</topic><topic>Aortic Valve Stenosis - pathology</topic><topic>Aortic Valve Stenosis - surgery</topic><topic>Bioprosthesis</topic><topic>Blood Vessel Prosthesis</topic><topic>Calcinosis - pathology</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Heart Ventricles - surgery</topic><topic>Humans</topic><topic>medial necrosis</topic><topic>Mitral Valve - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THEMAN, T. E.</creatorcontrib><creatorcontrib>SILVER, M. D.</creatorcontrib><creatorcontrib>HAUST, M. D.</creatorcontrib><creatorcontrib>McLOUGHLIN, M. J.</creatorcontrib><creatorcontrib>WIGLE, E. D.</creatorcontrib><creatorcontrib>WILLIAMS, W. R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THEMAN, T. E.</au><au>SILVER, M. D.</au><au>HAUST, M. D.</au><au>McLOUGHLIN, M. J.</au><au>WIGLE, E. D.</au><au>WILLIAMS, W. 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| fulltext | fulltext |
| identifier | ISSN: 0309-0167 |
| ispartof | Histopathology, 1979-05, Vol.3 (3), p.181-190 |
| issn | 0309-0167 1365-2559 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74610324 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adolescent Adult aorta Aorta - pathology Aorta, Abdominal - surgery Aorta, Thoracic - pathology aortic calcification Aortic Diseases - pathology aortic valve calcification Aortic Valve Insufficiency - pathology Aortic Valve Stenosis - pathology Aortic Valve Stenosis - surgery Bioprosthesis Blood Vessel Prosthesis Calcinosis - pathology Child, Preschool Female Heart Ventricles - surgery Humans medial necrosis Mitral Valve - pathology |
| title | Morphological findings in idiopathic calcification of the ascending aorta and aortic valve affecting a young woman |
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