Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling
Specific microRNA (miRNA) signatures have been associated with different cytogenetic subtypes in acute leukemias. This finding prompted us to investigate potential associations between genetic abnormalities in multiple myeloma (MM) and singular miRNA expression profiles. Moreover, global gene expres...
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| Veröffentlicht in: | Leukemia 2010-03, Vol.24 (3), p.629-637 |
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| creator | Gutiérrez, N C Sarasquete, M E Misiewicz-Krzeminska, I Delgado, M De Las Rivas, J Ticona, F V Fermiñán, E Martín-Jiménez, P Chillón, C Risueño, A Hernández, J M García-Sanz, R González, M San Miguel, J F |
| description | Specific microRNA (miRNA) signatures have been associated with different cytogenetic subtypes in acute leukemias. This finding prompted us to investigate potential associations between genetic abnormalities in multiple myeloma (MM) and singular miRNA expression profiles. Moreover, global gene expression profiling was also analyzed to find correlated miRNA gene expression and select miRNA target genes that show such correlation. For this purpose, we analyzed the expression level of 365 miRNAs and the gene expression profiling in 60 newly diagnosed MM patients, selected to represent the most relevant recurrent genetic abnormalities. Supervised analysis showed significantly deregulated miRNAs in the different cytogenetic subtypes as compared with normal PC. It is interesting to note that miR-1 and miR-133a clustered on the same chromosomal loci, were specifically overexpressed in the cases with t(14;16). The analysis of the relationship between miRNA expression and their respective target genes showed a conserved inverse correlation between several miRNAs deregulated in MM cells and
CCND2
expression level. These results illustrate, for the first time, that miRNA expression pattern in MM is associated with genetic abnormalities, and that the correlation of the expression profile of miRNA and their putative mRNA targets is useful to find statistically significant protein-coding genes in MM pathogenesis associated with changes in specific miRNAs. |
| doi_str_mv | 10.1038/leu.2009.274 |
| format | Article |
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CCND2
expression level. These results illustrate, for the first time, that miRNA expression pattern in MM is associated with genetic abnormalities, and that the correlation of the expression profile of miRNA and their putative mRNA targets is useful to find statistically significant protein-coding genes in MM pathogenesis associated with changes in specific miRNAs.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/leu.2009.274</identifier><identifier>PMID: 20054351</identifier><identifier>CODEN: LEUKED</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/191/2018 ; 631/208/2489/1381 ; 631/337/384/331 ; 692/699/67/1990/804 ; Abnormalities ; Basic-Leucine Zipper Transcription Factors - genetics ; Biological and medical sciences ; Cancer Research ; CD47 Antigen - genetics ; Chromosome Aberrations ; Chromosome abnormalities ; Complications and side effects ; Critical Care Medicine ; Cyclin D2 - genetics ; Cytogenetics ; Deregulation ; Gene expression ; Gene Expression Profiling ; Genes ; Genetic abnormalities ; Genetic analysis ; Genetic aspects ; Genetic regulation ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulinopathies ; Immunopathology ; Intensive ; Internal Medicine ; Leukemia ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Medicine ; Medicine & Public Health ; MicroRNA ; MicroRNAs ; MicroRNAs - analysis ; miRNA ; Multiple myeloma ; Multiple Myeloma - etiology ; Multiple Myeloma - genetics ; Oncology ; original-article ; Pathogenesis ; Physiological aspects ; Ribonucleic acid ; Risk factors ; RNA ; Statistical analysis</subject><ispartof>Leukemia, 2010-03, Vol.24 (3), p.629-637</ispartof><rights>Macmillan Publishers Limited 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2010</rights><rights>Macmillan Publishers Limited 2010.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-b85c06e7877cc43e71ff9dbc413286a9d8307f544f00c115b32ac6910b0ed9a93</citedby><cites>FETCH-LOGICAL-c581t-b85c06e7877cc43e71ff9dbc413286a9d8307f544f00c115b32ac6910b0ed9a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/leu.2009.274$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/leu.2009.274$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22529532$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20054351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gutiérrez, N C</creatorcontrib><creatorcontrib>Sarasquete, M E</creatorcontrib><creatorcontrib>Misiewicz-Krzeminska, I</creatorcontrib><creatorcontrib>Delgado, M</creatorcontrib><creatorcontrib>De Las Rivas, J</creatorcontrib><creatorcontrib>Ticona, F V</creatorcontrib><creatorcontrib>Fermiñán, E</creatorcontrib><creatorcontrib>Martín-Jiménez, P</creatorcontrib><creatorcontrib>Chillón, C</creatorcontrib><creatorcontrib>Risueño, A</creatorcontrib><creatorcontrib>Hernández, J M</creatorcontrib><creatorcontrib>García-Sanz, R</creatorcontrib><creatorcontrib>González, M</creatorcontrib><creatorcontrib>San Miguel, J F</creatorcontrib><title>Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><description>Specific microRNA (miRNA) signatures have been associated with different cytogenetic subtypes in acute leukemias. This finding prompted us to investigate potential associations between genetic abnormalities in multiple myeloma (MM) and singular miRNA expression profiles. Moreover, global gene expression profiling was also analyzed to find correlated miRNA gene expression and select miRNA target genes that show such correlation. For this purpose, we analyzed the expression level of 365 miRNAs and the gene expression profiling in 60 newly diagnosed MM patients, selected to represent the most relevant recurrent genetic abnormalities. Supervised analysis showed significantly deregulated miRNAs in the different cytogenetic subtypes as compared with normal PC. It is interesting to note that miR-1 and miR-133a clustered on the same chromosomal loci, were specifically overexpressed in the cases with t(14;16). The analysis of the relationship between miRNA expression and their respective target genes showed a conserved inverse correlation between several miRNAs deregulated in MM cells and
CCND2
expression level. These results illustrate, for the first time, that miRNA expression pattern in MM is associated with genetic abnormalities, and that the correlation of the expression profile of miRNA and their putative mRNA targets is useful to find statistically significant protein-coding genes in MM pathogenesis associated with changes in specific miRNAs.</description><subject>631/208/191/2018</subject><subject>631/208/2489/1381</subject><subject>631/337/384/331</subject><subject>692/699/67/1990/804</subject><subject>Abnormalities</subject><subject>Basic-Leucine Zipper Transcription Factors - genetics</subject><subject>Biological and medical sciences</subject><subject>Cancer Research</subject><subject>CD47 Antigen - genetics</subject><subject>Chromosome Aberrations</subject><subject>Chromosome abnormalities</subject><subject>Complications and side effects</subject><subject>Critical Care Medicine</subject><subject>Cyclin D2 - genetics</subject><subject>Cytogenetics</subject><subject>Deregulation</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Genes</subject><subject>Genetic abnormalities</subject><subject>Genetic analysis</subject><subject>Genetic aspects</subject><subject>Genetic regulation</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - analysis</subject><subject>miRNA</subject><subject>Multiple myeloma</subject><subject>Multiple Myeloma - etiology</subject><subject>Multiple Myeloma - genetics</subject><subject>Oncology</subject><subject>original-article</subject><subject>Pathogenesis</subject><subject>Physiological aspects</subject><subject>Ribonucleic acid</subject><subject>Risk factors</subject><subject>RNA</subject><subject>Statistical analysis</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkl2L1DAUhoso7rp657UURb2xYz6apL0c1k9YFESvS5qezGRJk9kkRecf-LNNZ0ZnV1aQXARynvcczpu3KB5jtMCINq8tTAuCULsgor5TnOJa8Ioxhu8Wp6hpRMVbUp8UD2K8RGgu8vvFSeZZTRk-LX6-gQCrycpkvCu9Lkejgv_yaVnCj02AGOdn48q0hnIwWmfapXIFDpJRZZz6tN1A3Aknm8zGQjluwfpRltINpfIhwKH5d5PWO-X11pvgtbHGrR4W97S0ER4d7rPi27u3X88_VBef3388X15UijU4VX3DFOIgGiGUqikIrHU79KrGlDRctkNDkdCsrjVCCmPWUyIVbzHqEQytbOlZ8XLfN0--miCmbjRRgbXSgZ9iJ2qOGs7Zf5CUZm8RJZl89hd56afg8hod4TUTNWoozdTTf1IEMS6waI-tVtJCZ5z2KUg1D-6WhGDOOBVNpha3UPkMkP_PO8iewk3Bi2uCNUib1tHbaf6YeBN8tQdzCmIMoLtNMKMM2w6jbs5bl_PWzXnrct4y_uSw09SPMPyBfwcsA88PgIxKWh2kUyYeOcJIy3YWVnsu5pJbQTiac-vgXyQ16vY</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Gutiérrez, N C</creator><creator>Sarasquete, M E</creator><creator>Misiewicz-Krzeminska, I</creator><creator>Delgado, M</creator><creator>De Las Rivas, J</creator><creator>Ticona, F V</creator><creator>Fermiñán, E</creator><creator>Martín-Jiménez, P</creator><creator>Chillón, C</creator><creator>Risueño, A</creator><creator>Hernández, J M</creator><creator>García-Sanz, R</creator><creator>González, M</creator><creator>San Miguel, J F</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20100301</creationdate><title>Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling</title><author>Gutiérrez, N C ; Sarasquete, M E ; Misiewicz-Krzeminska, I ; Delgado, M ; De Las Rivas, J ; Ticona, F V ; Fermiñán, E ; Martín-Jiménez, P ; Chillón, C ; Risueño, A ; Hernández, J M ; García-Sanz, R ; González, M ; San Miguel, J F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c581t-b85c06e7877cc43e71ff9dbc413286a9d8307f544f00c115b32ac6910b0ed9a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>631/208/191/2018</topic><topic>631/208/2489/1381</topic><topic>631/337/384/331</topic><topic>692/699/67/1990/804</topic><topic>Abnormalities</topic><topic>Basic-Leucine Zipper Transcription Factors - genetics</topic><topic>Biological and medical sciences</topic><topic>Cancer Research</topic><topic>CD47 Antigen - genetics</topic><topic>Chromosome Aberrations</topic><topic>Chromosome abnormalities</topic><topic>Complications and side effects</topic><topic>Critical Care Medicine</topic><topic>Cyclin D2 - genetics</topic><topic>Cytogenetics</topic><topic>Deregulation</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Genes</topic><topic>Genetic abnormalities</topic><topic>Genetic analysis</topic><topic>Genetic aspects</topic><topic>Genetic regulation</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Intensive</topic><topic>Internal Medicine</topic><topic>Leukemia</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - analysis</topic><topic>miRNA</topic><topic>Multiple myeloma</topic><topic>Multiple Myeloma - etiology</topic><topic>Multiple Myeloma - genetics</topic><topic>Oncology</topic><topic>original-article</topic><topic>Pathogenesis</topic><topic>Physiological aspects</topic><topic>Ribonucleic acid</topic><topic>Risk factors</topic><topic>RNA</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gutiérrez, N C</creatorcontrib><creatorcontrib>Sarasquete, M E</creatorcontrib><creatorcontrib>Misiewicz-Krzeminska, I</creatorcontrib><creatorcontrib>Delgado, M</creatorcontrib><creatorcontrib>De Las Rivas, J</creatorcontrib><creatorcontrib>Ticona, F V</creatorcontrib><creatorcontrib>Fermiñán, E</creatorcontrib><creatorcontrib>Martín-Jiménez, P</creatorcontrib><creatorcontrib>Chillón, C</creatorcontrib><creatorcontrib>Risueño, A</creatorcontrib><creatorcontrib>Hernández, J M</creatorcontrib><creatorcontrib>García-Sanz, R</creatorcontrib><creatorcontrib>González, M</creatorcontrib><creatorcontrib>San Miguel, J F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - 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This finding prompted us to investigate potential associations between genetic abnormalities in multiple myeloma (MM) and singular miRNA expression profiles. Moreover, global gene expression profiling was also analyzed to find correlated miRNA gene expression and select miRNA target genes that show such correlation. For this purpose, we analyzed the expression level of 365 miRNAs and the gene expression profiling in 60 newly diagnosed MM patients, selected to represent the most relevant recurrent genetic abnormalities. Supervised analysis showed significantly deregulated miRNAs in the different cytogenetic subtypes as compared with normal PC. It is interesting to note that miR-1 and miR-133a clustered on the same chromosomal loci, were specifically overexpressed in the cases with t(14;16). The analysis of the relationship between miRNA expression and their respective target genes showed a conserved inverse correlation between several miRNAs deregulated in MM cells and
CCND2
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| subjects | 631/208/191/2018 631/208/2489/1381 631/337/384/331 692/699/67/1990/804 Abnormalities Basic-Leucine Zipper Transcription Factors - genetics Biological and medical sciences Cancer Research CD47 Antigen - genetics Chromosome Aberrations Chromosome abnormalities Complications and side effects Critical Care Medicine Cyclin D2 - genetics Cytogenetics Deregulation Gene expression Gene Expression Profiling Genes Genetic abnormalities Genetic analysis Genetic aspects Genetic regulation Hematologic and hematopoietic diseases Hematology Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Intensive Internal Medicine Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Medicine Medicine & Public Health MicroRNA MicroRNAs MicroRNAs - analysis miRNA Multiple myeloma Multiple Myeloma - etiology Multiple Myeloma - genetics Oncology original-article Pathogenesis Physiological aspects Ribonucleic acid Risk factors RNA Statistical analysis |
| title | Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling |
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