No pharmacokinetic interaction between paliperidone extended-release tablets and trimethoprim in healthy subjects

Objective The effect of trimethoprim, a potent organic cation transport inhibitor, on the pharmacokinetics (PK) of paliperidone extended‐release tablets (paliperidone ER), an organic cation mainly eliminated via renal excretion, was assessed. Methods Open‐label, two‐period, randomized, crossover stu...

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Veröffentlicht in:	Human psychopharmacology 2009-10, Vol.24 (7), p.532-539
Hauptverfasser:	Thyssen, An, Cleton, Adriaan, Talluri, Krishna, Leempoels, Jos, Janssens, Luc, Boom, Sandra, Eerdekens, Marielle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of Variance Antipsychotic Agents - blood Antipsychotic Agents - pharmacokinetics Antipsychotic Agents - urine Area Under Curve Cross-Over Studies Drug Administration Schedule Drug Delivery Systems drug interaction Drug Interactions Electrocardiography - methods Folic Acid Antagonists - blood Folic Acid Antagonists - pharmacokinetics Folic Acid Antagonists - urine Heart Rate - drug effects Heart Rate - physiology Humans Isoxazoles - blood Isoxazoles - pharmacokinetics Isoxazoles - urine Male Middle Aged Paliperidone Paliperidone Palmitate pharmacokinetics Pyrimidines - blood Pyrimidines - pharmacokinetics Pyrimidines - urine Single-Blind Method Time Factors trimethoprim Trimethoprim - blood Trimethoprim - pharmacokinetics Trimethoprim - urine Young Adult
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