Neuroprotective effects of Lepidium meyenii (Maca)
The neuroprotective activity of the plant Lepidium meyenii (Maca) was studied in two experimental models: in vitro and in vivo. Crayfish neurons were pretreated with vehicle or the pentane extract from Maca, subjected to H2O2, and their viability determined microscopically and chemically. A signific...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2010-06, Vol.1199 (1), p.77-85 |
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| creator | Pino-Figueroa, Alejandro Nguyen, Diane Maher, Timothy J. |
| description | The neuroprotective activity of the plant Lepidium meyenii (Maca) was studied in two experimental models: in vitro and in vivo. Crayfish neurons were pretreated with vehicle or the pentane extract from Maca, subjected to H2O2, and their viability determined microscopically and chemically. A significant concentration‐neuroprotective effect relationship was demonstrated. The pentane extract was then administered intravenously to rats prior to and following middle cerebral artery occlusion. While infarct volumes were decreased for the lower dose, higher doses increased infarct volumes compared to controls. These results suggest a potential application of Maca as a neuroprotectant. |
| doi_str_mv | 10.1111/j.1749-6632.2009.05174.x |
| format | Article |
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Crayfish neurons were pretreated with vehicle or the pentane extract from Maca, subjected to H2O2, and their viability determined microscopically and chemically. A significant concentration‐neuroprotective effect relationship was demonstrated. The pentane extract was then administered intravenously to rats prior to and following middle cerebral artery occlusion. While infarct volumes were decreased for the lower dose, higher doses increased infarct volumes compared to controls. 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Crayfish neurons were pretreated with vehicle or the pentane extract from Maca, subjected to H2O2, and their viability determined microscopically and chemically. A significant concentration‐neuroprotective effect relationship was demonstrated. The pentane extract was then administered intravenously to rats prior to and following middle cerebral artery occlusion. While infarct volumes were decreased for the lower dose, higher doses increased infarct volumes compared to controls. 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| subjects | Animals Astacoidea Brain Ischemia - prevention & control Cambaridae cerebral ischemia crayfish neurons Dose-Response Relationship, Drug In Vitro Techniques Infarction, Middle Cerebral Artery - pathology Lepidium Lepidium - chemistry Maca Male Neuroprotective Agents - pharmacology Plant Extracts - pharmacology Rats Rats, Sprague-Dawley Rodents |
| title | Neuroprotective effects of Lepidium meyenii (Maca) |
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