Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depression
Major depression (MD) has been associated with decreased brain-derived neurotrophic factor (BDNF) serum levels, while antidepressant drugs were found to increase these decreased BDNF levels. We investigated if this is also caused by a single exercise session in elderly women with remitted MD. In our...
Gespeichert in:
| Veröffentlicht in: | The international journal of neuropsychopharmacology 2010-06, Vol.13 (5), p.595-602 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 602 |
|---|---|
| container_issue | 5 |
| container_start_page | 595 |
| container_title | The international journal of neuropsychopharmacology |
| container_volume | 13 |
| creator | Laske, Christoph Banschbach, Sabine Stransky, Elke Bosch, Sabine Straten, Guido Machann, Jürgen Fritsche, Andreas Hipp, Arno Niess, Andreas Eschweiler, Gerhard W. |
| description | Major depression (MD) has been associated with decreased brain-derived neurotrophic factor (BDNF) serum levels, while antidepressant drugs were found to increase these decreased BDNF levels. We investigated if this is also caused by a single exercise session in elderly women with remitted MD. In our study 35 elderly women with a (partially) remitted depressive episode of unipolar depression according to DSM-IV criteria within the last year and 20 age-matched healthy female controls were included. Depression severity was assessed by HAMD. Serum levels of BDNF were measured by ELISA. Blood samples were taken during the rest period before beginning the exercise including spiroergometry, at the end of the exercise and after a 30-min recovery period. At baseline MD patients showed significantly decreased BDNF serum levels compared to healthy female controls. After a single 30-min exercise period, we found a significant increase of BDNF serum levels in MD patients towards values comparable with the baseline levels of the healthy controls, followed by a significant decrease after 30 min rest, while the healthy controls showed only a mild but non-significant increase. In conclusion, a single exercise session leads to a significant up-regulation and transient normalization of BDNF serum levels in elderly women with remitted MD. This mechanism may contribute to the beneficial therapeutic and relapse-preventing effects of physical activity on MD. |
| doi_str_mv | 10.1017/S1461145709991234 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_746083015</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S1461145709991234</cupid><sourcerecordid>733535050</sourcerecordid><originalsourceid>FETCH-LOGICAL-c494t-91b384d95b27ee43a0860c917aec474b40231faccbf82affb6d02c93b67da2983</originalsourceid><addsrcrecordid>eNqFkU1vFSEUhomxsR_6A9yYiRtXYznAwLDU2laTRhfqesLAGeVmgCvMpNZfL_VebVJjZAPhPO9DyEvIU6AvgYI6_QhCAohOUa01MC4ekKN6pdsOAB7-OkN7Oz8kx6VsKGWi4_IROWSUSiUlHJHl_Dtm6wu2PrrVomtiysHM_odZfIpNmhqHNqMpdfT6zfuLpmBeQ2NTtBiXvKN8bHB2mOeb5joFjM21X742GYNflpoLZpNy9WwzllL5x-RgMnPBJ_v9hHy-OP909ra9-nD57uzVVWuFFkurYeS9cLobmUIU3NBeUqtBGbRCiVFQxmEy1o5Tz8w0jdJRZjUfpXKG6Z6fkBc77zanbyuWZQi-WJxnEzGtZVBC0p5T6P5Pct7xjna0ks_vkZu05li_MbC6eqYkqxDsIJtTKRmnYZt9MPlmADrcVjf8VV3NPNuL1zGg-5P43VUF-F5qwpi9-4J3T_9b-xPbpKQZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222282762</pqid></control><display><type>article</type><title>Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depression</title><source>MEDLINE</source><source>Access via Oxford University Press (Open Access Collection)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Laske, Christoph ; Banschbach, Sabine ; Stransky, Elke ; Bosch, Sabine ; Straten, Guido ; Machann, Jürgen ; Fritsche, Andreas ; Hipp, Arno ; Niess, Andreas ; Eschweiler, Gerhard W.</creator><creatorcontrib>Laske, Christoph ; Banschbach, Sabine ; Stransky, Elke ; Bosch, Sabine ; Straten, Guido ; Machann, Jürgen ; Fritsche, Andreas ; Hipp, Arno ; Niess, Andreas ; Eschweiler, Gerhard W.</creatorcontrib><description>Major depression (MD) has been associated with decreased brain-derived neurotrophic factor (BDNF) serum levels, while antidepressant drugs were found to increase these decreased BDNF levels. We investigated if this is also caused by a single exercise session in elderly women with remitted MD. In our study 35 elderly women with a (partially) remitted depressive episode of unipolar depression according to DSM-IV criteria within the last year and 20 age-matched healthy female controls were included. Depression severity was assessed by HAMD. Serum levels of BDNF were measured by ELISA. Blood samples were taken during the rest period before beginning the exercise including spiroergometry, at the end of the exercise and after a 30-min recovery period. At baseline MD patients showed significantly decreased BDNF serum levels compared to healthy female controls. After a single 30-min exercise period, we found a significant increase of BDNF serum levels in MD patients towards values comparable with the baseline levels of the healthy controls, followed by a significant decrease after 30 min rest, while the healthy controls showed only a mild but non-significant increase. In conclusion, a single exercise session leads to a significant up-regulation and transient normalization of BDNF serum levels in elderly women with remitted MD. This mechanism may contribute to the beneficial therapeutic and relapse-preventing effects of physical activity on MD.</description><identifier>ISSN: 1461-1457</identifier><identifier>EISSN: 1469-5111</identifier><identifier>DOI: 10.1017/S1461145709991234</identifier><identifier>PMID: 20067661</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Aged ; Biomarkers - blood ; Brain-Derived Neurotrophic Factor - biosynthesis ; Brain-Derived Neurotrophic Factor - blood ; Depressive Disorder, Major - blood ; Depressive Disorder, Major - prevention & control ; Depressive Disorder, Major - psychology ; Exercise - physiology ; Exercise - psychology ; Exercise Test - methods ; Exercise Test - psychology ; Female ; Humans ; Middle Aged ; Recombinant Proteins - biosynthesis ; Recurrence</subject><ispartof>The international journal of neuropsychopharmacology, 2010-06, Vol.13 (5), p.595-602</ispartof><rights>Copyright © CINP 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-91b384d95b27ee43a0860c917aec474b40231faccbf82affb6d02c93b67da2983</citedby><cites>FETCH-LOGICAL-c494t-91b384d95b27ee43a0860c917aec474b40231faccbf82affb6d02c93b67da2983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20067661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laske, Christoph</creatorcontrib><creatorcontrib>Banschbach, Sabine</creatorcontrib><creatorcontrib>Stransky, Elke</creatorcontrib><creatorcontrib>Bosch, Sabine</creatorcontrib><creatorcontrib>Straten, Guido</creatorcontrib><creatorcontrib>Machann, Jürgen</creatorcontrib><creatorcontrib>Fritsche, Andreas</creatorcontrib><creatorcontrib>Hipp, Arno</creatorcontrib><creatorcontrib>Niess, Andreas</creatorcontrib><creatorcontrib>Eschweiler, Gerhard W.</creatorcontrib><title>Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depression</title><title>The international journal of neuropsychopharmacology</title><addtitle>Int J Neuropsychopharmacol</addtitle><description>Major depression (MD) has been associated with decreased brain-derived neurotrophic factor (BDNF) serum levels, while antidepressant drugs were found to increase these decreased BDNF levels. We investigated if this is also caused by a single exercise session in elderly women with remitted MD. In our study 35 elderly women with a (partially) remitted depressive episode of unipolar depression according to DSM-IV criteria within the last year and 20 age-matched healthy female controls were included. Depression severity was assessed by HAMD. Serum levels of BDNF were measured by ELISA. Blood samples were taken during the rest period before beginning the exercise including spiroergometry, at the end of the exercise and after a 30-min recovery period. At baseline MD patients showed significantly decreased BDNF serum levels compared to healthy female controls. After a single 30-min exercise period, we found a significant increase of BDNF serum levels in MD patients towards values comparable with the baseline levels of the healthy controls, followed by a significant decrease after 30 min rest, while the healthy controls showed only a mild but non-significant increase. In conclusion, a single exercise session leads to a significant up-regulation and transient normalization of BDNF serum levels in elderly women with remitted MD. This mechanism may contribute to the beneficial therapeutic and relapse-preventing effects of physical activity on MD.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Brain-Derived Neurotrophic Factor - biosynthesis</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Depressive Disorder, Major - blood</subject><subject>Depressive Disorder, Major - prevention & control</subject><subject>Depressive Disorder, Major - psychology</subject><subject>Exercise - physiology</subject><subject>Exercise - psychology</subject><subject>Exercise Test - methods</subject><subject>Exercise Test - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Recombinant Proteins - biosynthesis</subject><subject>Recurrence</subject><issn>1461-1457</issn><issn>1469-5111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1vFSEUhomxsR_6A9yYiRtXYznAwLDU2laTRhfqesLAGeVmgCvMpNZfL_VebVJjZAPhPO9DyEvIU6AvgYI6_QhCAohOUa01MC4ekKN6pdsOAB7-OkN7Oz8kx6VsKGWi4_IROWSUSiUlHJHl_Dtm6wu2PrrVomtiysHM_odZfIpNmhqHNqMpdfT6zfuLpmBeQ2NTtBiXvKN8bHB2mOeb5joFjM21X742GYNflpoLZpNy9WwzllL5x-RgMnPBJ_v9hHy-OP909ra9-nD57uzVVWuFFkurYeS9cLobmUIU3NBeUqtBGbRCiVFQxmEy1o5Tz8w0jdJRZjUfpXKG6Z6fkBc77zanbyuWZQi-WJxnEzGtZVBC0p5T6P5Pct7xjna0ks_vkZu05li_MbC6eqYkqxDsIJtTKRmnYZt9MPlmADrcVjf8VV3NPNuL1zGg-5P43VUF-F5qwpi9-4J3T_9b-xPbpKQZ</recordid><startdate>201006</startdate><enddate>201006</enddate><creator>Laske, Christoph</creator><creator>Banschbach, Sabine</creator><creator>Stransky, Elke</creator><creator>Bosch, Sabine</creator><creator>Straten, Guido</creator><creator>Machann, Jürgen</creator><creator>Fritsche, Andreas</creator><creator>Hipp, Arno</creator><creator>Niess, Andreas</creator><creator>Eschweiler, Gerhard W.</creator><general>Cambridge University Press</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201006</creationdate><title>Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depression</title><author>Laske, Christoph ; Banschbach, Sabine ; Stransky, Elke ; Bosch, Sabine ; Straten, Guido ; Machann, Jürgen ; Fritsche, Andreas ; Hipp, Arno ; Niess, Andreas ; Eschweiler, Gerhard W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-91b384d95b27ee43a0860c917aec474b40231faccbf82affb6d02c93b67da2983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Brain-Derived Neurotrophic Factor - biosynthesis</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>Depressive Disorder, Major - blood</topic><topic>Depressive Disorder, Major - prevention & control</topic><topic>Depressive Disorder, Major - psychology</topic><topic>Exercise - physiology</topic><topic>Exercise - psychology</topic><topic>Exercise Test - methods</topic><topic>Exercise Test - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Recombinant Proteins - biosynthesis</topic><topic>Recurrence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laske, Christoph</creatorcontrib><creatorcontrib>Banschbach, Sabine</creatorcontrib><creatorcontrib>Stransky, Elke</creatorcontrib><creatorcontrib>Bosch, Sabine</creatorcontrib><creatorcontrib>Straten, Guido</creatorcontrib><creatorcontrib>Machann, Jürgen</creatorcontrib><creatorcontrib>Fritsche, Andreas</creatorcontrib><creatorcontrib>Hipp, Arno</creatorcontrib><creatorcontrib>Niess, Andreas</creatorcontrib><creatorcontrib>Eschweiler, Gerhard W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>The international journal of neuropsychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laske, Christoph</au><au>Banschbach, Sabine</au><au>Stransky, Elke</au><au>Bosch, Sabine</au><au>Straten, Guido</au><au>Machann, Jürgen</au><au>Fritsche, Andreas</au><au>Hipp, Arno</au><au>Niess, Andreas</au><au>Eschweiler, Gerhard W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depression</atitle><jtitle>The international journal of neuropsychopharmacology</jtitle><addtitle>Int J Neuropsychopharmacol</addtitle><date>2010-06</date><risdate>2010</risdate><volume>13</volume><issue>5</issue><spage>595</spage><epage>602</epage><pages>595-602</pages><issn>1461-1457</issn><eissn>1469-5111</eissn><abstract>Major depression (MD) has been associated with decreased brain-derived neurotrophic factor (BDNF) serum levels, while antidepressant drugs were found to increase these decreased BDNF levels. We investigated if this is also caused by a single exercise session in elderly women with remitted MD. In our study 35 elderly women with a (partially) remitted depressive episode of unipolar depression according to DSM-IV criteria within the last year and 20 age-matched healthy female controls were included. Depression severity was assessed by HAMD. Serum levels of BDNF were measured by ELISA. Blood samples were taken during the rest period before beginning the exercise including spiroergometry, at the end of the exercise and after a 30-min recovery period. At baseline MD patients showed significantly decreased BDNF serum levels compared to healthy female controls. After a single 30-min exercise period, we found a significant increase of BDNF serum levels in MD patients towards values comparable with the baseline levels of the healthy controls, followed by a significant decrease after 30 min rest, while the healthy controls showed only a mild but non-significant increase. In conclusion, a single exercise session leads to a significant up-regulation and transient normalization of BDNF serum levels in elderly women with remitted MD. This mechanism may contribute to the beneficial therapeutic and relapse-preventing effects of physical activity on MD.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>20067661</pmid><doi>10.1017/S1461145709991234</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1461-1457 |
| ispartof | The international journal of neuropsychopharmacology, 2010-06, Vol.13 (5), p.595-602 |
| issn | 1461-1457 1469-5111 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_746083015 |
| source | MEDLINE; Access via Oxford University Press (Open Access Collection); EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Biomarkers - blood Brain-Derived Neurotrophic Factor - biosynthesis Brain-Derived Neurotrophic Factor - blood Depressive Disorder, Major - blood Depressive Disorder, Major - prevention & control Depressive Disorder, Major - psychology Exercise - physiology Exercise - psychology Exercise Test - methods Exercise Test - psychology Female Humans Middle Aged Recombinant Proteins - biosynthesis Recurrence |
| title | Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T13%3A42%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Exercise-induced%20normalization%20of%20decreased%20BDNF%20serum%20concentration%20in%20elderly%20women%20with%20remitted%20major%20depression&rft.jtitle=The%20international%20journal%20of%20neuropsychopharmacology&rft.au=Laske,%20Christoph&rft.date=2010-06&rft.volume=13&rft.issue=5&rft.spage=595&rft.epage=602&rft.pages=595-602&rft.issn=1461-1457&rft.eissn=1469-5111&rft_id=info:doi/10.1017/S1461145709991234&rft_dat=%3Cproquest_cross%3E733535050%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222282762&rft_id=info:pmid/20067661&rft_cupid=10_1017_S1461145709991234&rfr_iscdi=true |