Modeling the influence of cyclodextrins on oral absorption of low solubility drugs: II. Experimental validation
A model was developed for predicting the influence of cyclodextrins (CDs) delivered as a physical mixture with drug on oral absorption. CDs are cyclic oligosaccharides which form inclusion complexes with many drugs and are often used as solubilizing agents. The purpose of this work is to compare the...
Gespeichert in:
| Veröffentlicht in: | Biotechnology and bioengineering 2010-02, Vol.105 (2), p.421-430 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 430 |
|---|---|
| container_issue | 2 |
| container_start_page | 421 |
| container_title | Biotechnology and bioengineering |
| container_volume | 105 |
| creator | Gamsiz, Ece Dilber Miller, Lee Thombre, Avinash G Ahmed, Imran Carrier, Rebecca Lyn |
| description | A model was developed for predicting the influence of cyclodextrins (CDs) delivered as a physical mixture with drug on oral absorption. CDs are cyclic oligosaccharides which form inclusion complexes with many drugs and are often used as solubilizing agents. The purpose of this work is to compare the simulation predictions with in vitro as well as in vivo experimental results to test the model's ability to capture the influence of CD on key processes in the gastrointestinal (GI) tract environment. Dissolution and absorption kinetics of low solubility drugs (Naproxen and Nifedipine) were tested in the presence and absence of CD in a simulated gastrointestinal environment. Model predictions were also compared with in vivo experimental results (Glibenclamide and Carbamazepine) from the literature to demonstrate the model's ability to predict oral bioavailability. Comparisons of simulation and experimental results indicate that a model incorporating the influence of CD (delivered as a physical mixture) on dissolution kinetics and binding of neutral drug can predict trends in the influence of CD on bioavailability. Overall, a minimal effect of CD dosed as a physical mixture was observed and predicted. Modeling may aid in enabling rational design of CD containing formulations. Biotechnol. Bioeng. 2010; 105: 421-430. |
| doi_str_mv | 10.1002/bit.22524 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_746082220</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734213927</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5074-162de7f6e6d4013b0528086bde234f97f1163fb2780f7673d1302c90add364ee3</originalsourceid><addsrcrecordid>eNqNkV9v0zAUxSMEYmPwwBcACwkhHtJdXyd2sjdWbaNSBw9sAvFiOYldPNy42Alrvz0uLUNCQvBkXfl37p9zsuwphQkFwOPGDhPEEot72SGFWuSANdzPDgGA56ys8SB7FONNKkXF-cPsgNYCSyjYYeYvfaed7Rdk-KKJ7Y0bdd9q4g1pN61Ln-sh2D4S3xMflCOqiT6sBrutDXH-lkTvxsY6O2xIF8ZFPCGz2YScrVc62KXuhyT6rpzt1Fb0OHtglIv6yf49yq7Pz66mb_P5-4vZ9M08b0sQRU45dloYrnlXAGUNlFhBxZtOIytMLQylnJkGRQVGcME6ygDbGlTXMV5ozY6yV7u-q-C_jToOcmljq51TvfZjlKLgUCEi_AfJeLKrqP5NsgIpq1Ek8sUf5I0fQ58OlokQnCJu273eQW3wMQZt5CoZpsJGUpDbXGXKVf7MNbHP9g3HZqm73-Q-yAS83AMqtsqZoPrWxjsOkdGirLZDj3fcrXV68_eJ8nR29Wt0vlPYOOj1nUKFrzIZL0r58d2FnE9PS_z0-VxeJv75jjfKS7UIaYvrD5hCBCrS8SDYD00z0EU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213761228</pqid></control><display><type>article</type><title>Modeling the influence of cyclodextrins on oral absorption of low solubility drugs: II. Experimental validation</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Gamsiz, Ece Dilber ; Miller, Lee ; Thombre, Avinash G ; Ahmed, Imran ; Carrier, Rebecca Lyn</creator><creatorcontrib>Gamsiz, Ece Dilber ; Miller, Lee ; Thombre, Avinash G ; Ahmed, Imran ; Carrier, Rebecca Lyn</creatorcontrib><description>A model was developed for predicting the influence of cyclodextrins (CDs) delivered as a physical mixture with drug on oral absorption. CDs are cyclic oligosaccharides which form inclusion complexes with many drugs and are often used as solubilizing agents. The purpose of this work is to compare the simulation predictions with in vitro as well as in vivo experimental results to test the model's ability to capture the influence of CD on key processes in the gastrointestinal (GI) tract environment. Dissolution and absorption kinetics of low solubility drugs (Naproxen and Nifedipine) were tested in the presence and absence of CD in a simulated gastrointestinal environment. Model predictions were also compared with in vivo experimental results (Glibenclamide and Carbamazepine) from the literature to demonstrate the model's ability to predict oral bioavailability. Comparisons of simulation and experimental results indicate that a model incorporating the influence of CD (delivered as a physical mixture) on dissolution kinetics and binding of neutral drug can predict trends in the influence of CD on bioavailability. Overall, a minimal effect of CD dosed as a physical mixture was observed and predicted. Modeling may aid in enabling rational design of CD containing formulations. Biotechnol. Bioeng. 2010; 105: 421-430.</description><identifier>ISSN: 0006-3592</identifier><identifier>EISSN: 1097-0290</identifier><identifier>DOI: 10.1002/bit.22524</identifier><identifier>PMID: 19725043</identifier><identifier>CODEN: BIBIAU</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Absorption ; Administration, Oral ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics ; Bioavailability ; Biological and medical sciences ; Biological Availability ; Biotechnology ; Calcium Channel Blockers - administration & dosage ; Calcium Channel Blockers - chemistry ; Calcium Channel Blockers - pharmacokinetics ; Comparative analysis ; cyclodextrins ; Cyclodextrins - chemistry ; Dissolution ; Drug Carriers - chemistry ; Drugs ; Fundamental and applied biological sciences. Psychology ; modeling ; Models, Biological ; Naproxen - administration & dosage ; Naproxen - chemistry ; Naproxen - pharmacokinetics ; Nifedipine - administration & dosage ; Nifedipine - chemistry ; Nifedipine - pharmacokinetics ; Pharmaceutical Preparations - administration & dosage ; Pharmaceutical Preparations - chemistry ; poorly-soluble drugs ; Simulation ; Solubility</subject><ispartof>Biotechnology and bioengineering, 2010-02, Vol.105 (2), p.421-430</ispartof><rights>Copyright © 2009 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>2009 Wiley Periodicals, Inc.</rights><rights>Copyright John Wiley and Sons, Limited Feb 1, 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5074-162de7f6e6d4013b0528086bde234f97f1163fb2780f7673d1302c90add364ee3</citedby><cites>FETCH-LOGICAL-c5074-162de7f6e6d4013b0528086bde234f97f1163fb2780f7673d1302c90add364ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbit.22524$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbit.22524$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22314588$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19725043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gamsiz, Ece Dilber</creatorcontrib><creatorcontrib>Miller, Lee</creatorcontrib><creatorcontrib>Thombre, Avinash G</creatorcontrib><creatorcontrib>Ahmed, Imran</creatorcontrib><creatorcontrib>Carrier, Rebecca Lyn</creatorcontrib><title>Modeling the influence of cyclodextrins on oral absorption of low solubility drugs: II. Experimental validation</title><title>Biotechnology and bioengineering</title><addtitle>Biotechnol. Bioeng</addtitle><description>A model was developed for predicting the influence of cyclodextrins (CDs) delivered as a physical mixture with drug on oral absorption. CDs are cyclic oligosaccharides which form inclusion complexes with many drugs and are often used as solubilizing agents. The purpose of this work is to compare the simulation predictions with in vitro as well as in vivo experimental results to test the model's ability to capture the influence of CD on key processes in the gastrointestinal (GI) tract environment. Dissolution and absorption kinetics of low solubility drugs (Naproxen and Nifedipine) were tested in the presence and absence of CD in a simulated gastrointestinal environment. Model predictions were also compared with in vivo experimental results (Glibenclamide and Carbamazepine) from the literature to demonstrate the model's ability to predict oral bioavailability. Comparisons of simulation and experimental results indicate that a model incorporating the influence of CD (delivered as a physical mixture) on dissolution kinetics and binding of neutral drug can predict trends in the influence of CD on bioavailability. Overall, a minimal effect of CD dosed as a physical mixture was observed and predicted. Modeling may aid in enabling rational design of CD containing formulations. Biotechnol. Bioeng. 2010; 105: 421-430.</description><subject>Absorption</subject><subject>Administration, Oral</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</subject><subject>Bioavailability</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Biotechnology</subject><subject>Calcium Channel Blockers - administration & dosage</subject><subject>Calcium Channel Blockers - chemistry</subject><subject>Calcium Channel Blockers - pharmacokinetics</subject><subject>Comparative analysis</subject><subject>cyclodextrins</subject><subject>Cyclodextrins - chemistry</subject><subject>Dissolution</subject><subject>Drug Carriers - chemistry</subject><subject>Drugs</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>modeling</subject><subject>Models, Biological</subject><subject>Naproxen - administration & dosage</subject><subject>Naproxen - chemistry</subject><subject>Naproxen - pharmacokinetics</subject><subject>Nifedipine - administration & dosage</subject><subject>Nifedipine - chemistry</subject><subject>Nifedipine - pharmacokinetics</subject><subject>Pharmaceutical Preparations - administration & dosage</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>poorly-soluble drugs</subject><subject>Simulation</subject><subject>Solubility</subject><issn>0006-3592</issn><issn>1097-0290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV9v0zAUxSMEYmPwwBcACwkhHtJdXyd2sjdWbaNSBw9sAvFiOYldPNy42Alrvz0uLUNCQvBkXfl37p9zsuwphQkFwOPGDhPEEot72SGFWuSANdzPDgGA56ys8SB7FONNKkXF-cPsgNYCSyjYYeYvfaed7Rdk-KKJ7Y0bdd9q4g1pN61Ln-sh2D4S3xMflCOqiT6sBrutDXH-lkTvxsY6O2xIF8ZFPCGz2YScrVc62KXuhyT6rpzt1Fb0OHtglIv6yf49yq7Pz66mb_P5-4vZ9M08b0sQRU45dloYrnlXAGUNlFhBxZtOIytMLQylnJkGRQVGcME6ygDbGlTXMV5ozY6yV7u-q-C_jToOcmljq51TvfZjlKLgUCEi_AfJeLKrqP5NsgIpq1Ek8sUf5I0fQ58OlokQnCJu273eQW3wMQZt5CoZpsJGUpDbXGXKVf7MNbHP9g3HZqm73-Q-yAS83AMqtsqZoPrWxjsOkdGirLZDj3fcrXV68_eJ8nR29Wt0vlPYOOj1nUKFrzIZL0r58d2FnE9PS_z0-VxeJv75jjfKS7UIaYvrD5hCBCrS8SDYD00z0EU</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Gamsiz, Ece Dilber</creator><creator>Miller, Lee</creator><creator>Thombre, Avinash G</creator><creator>Ahmed, Imran</creator><creator>Carrier, Rebecca Lyn</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20100201</creationdate><title>Modeling the influence of cyclodextrins on oral absorption of low solubility drugs: II. Experimental validation</title><author>Gamsiz, Ece Dilber ; Miller, Lee ; Thombre, Avinash G ; Ahmed, Imran ; Carrier, Rebecca Lyn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5074-162de7f6e6d4013b0528086bde234f97f1163fb2780f7673d1302c90add364ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Absorption</topic><topic>Administration, Oral</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</topic><topic>Bioavailability</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Biotechnology</topic><topic>Calcium Channel Blockers - administration & dosage</topic><topic>Calcium Channel Blockers - chemistry</topic><topic>Calcium Channel Blockers - pharmacokinetics</topic><topic>Comparative analysis</topic><topic>cyclodextrins</topic><topic>Cyclodextrins - chemistry</topic><topic>Dissolution</topic><topic>Drug Carriers - chemistry</topic><topic>Drugs</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>modeling</topic><topic>Models, Biological</topic><topic>Naproxen - administration & dosage</topic><topic>Naproxen - chemistry</topic><topic>Naproxen - pharmacokinetics</topic><topic>Nifedipine - administration & dosage</topic><topic>Nifedipine - chemistry</topic><topic>Nifedipine - pharmacokinetics</topic><topic>Pharmaceutical Preparations - administration & dosage</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>poorly-soluble drugs</topic><topic>Simulation</topic><topic>Solubility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gamsiz, Ece Dilber</creatorcontrib><creatorcontrib>Miller, Lee</creatorcontrib><creatorcontrib>Thombre, Avinash G</creatorcontrib><creatorcontrib>Ahmed, Imran</creatorcontrib><creatorcontrib>Carrier, Rebecca Lyn</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biotechnology and bioengineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gamsiz, Ece Dilber</au><au>Miller, Lee</au><au>Thombre, Avinash G</au><au>Ahmed, Imran</au><au>Carrier, Rebecca Lyn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modeling the influence of cyclodextrins on oral absorption of low solubility drugs: II. Experimental validation</atitle><jtitle>Biotechnology and bioengineering</jtitle><addtitle>Biotechnol. Bioeng</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>105</volume><issue>2</issue><spage>421</spage><epage>430</epage><pages>421-430</pages><issn>0006-3592</issn><eissn>1097-0290</eissn><coden>BIBIAU</coden><abstract>A model was developed for predicting the influence of cyclodextrins (CDs) delivered as a physical mixture with drug on oral absorption. CDs are cyclic oligosaccharides which form inclusion complexes with many drugs and are often used as solubilizing agents. The purpose of this work is to compare the simulation predictions with in vitro as well as in vivo experimental results to test the model's ability to capture the influence of CD on key processes in the gastrointestinal (GI) tract environment. Dissolution and absorption kinetics of low solubility drugs (Naproxen and Nifedipine) were tested in the presence and absence of CD in a simulated gastrointestinal environment. Model predictions were also compared with in vivo experimental results (Glibenclamide and Carbamazepine) from the literature to demonstrate the model's ability to predict oral bioavailability. Comparisons of simulation and experimental results indicate that a model incorporating the influence of CD (delivered as a physical mixture) on dissolution kinetics and binding of neutral drug can predict trends in the influence of CD on bioavailability. Overall, a minimal effect of CD dosed as a physical mixture was observed and predicted. Modeling may aid in enabling rational design of CD containing formulations. Biotechnol. Bioeng. 2010; 105: 421-430.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19725043</pmid><doi>10.1002/bit.22524</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3592 |
| ispartof | Biotechnology and bioengineering, 2010-02, Vol.105 (2), p.421-430 |
| issn | 0006-3592 1097-0290 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_746082220 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Absorption Administration, Oral Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Bioavailability Biological and medical sciences Biological Availability Biotechnology Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - chemistry Calcium Channel Blockers - pharmacokinetics Comparative analysis cyclodextrins Cyclodextrins - chemistry Dissolution Drug Carriers - chemistry Drugs Fundamental and applied biological sciences. Psychology modeling Models, Biological Naproxen - administration & dosage Naproxen - chemistry Naproxen - pharmacokinetics Nifedipine - administration & dosage Nifedipine - chemistry Nifedipine - pharmacokinetics Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - chemistry poorly-soluble drugs Simulation Solubility |
| title | Modeling the influence of cyclodextrins on oral absorption of low solubility drugs: II. Experimental validation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T06%3A46%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Modeling%20the%20influence%20of%20cyclodextrins%20on%20oral%20absorption%20of%20low%20solubility%20drugs:%20II.%20Experimental%20validation&rft.jtitle=Biotechnology%20and%20bioengineering&rft.au=Gamsiz,%20Ece%20Dilber&rft.date=2010-02-01&rft.volume=105&rft.issue=2&rft.spage=421&rft.epage=430&rft.pages=421-430&rft.issn=0006-3592&rft.eissn=1097-0290&rft.coden=BIBIAU&rft_id=info:doi/10.1002/bit.22524&rft_dat=%3Cproquest_cross%3E734213927%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213761228&rft_id=info:pmid/19725043&rfr_iscdi=true |