Genetic and epigenetic classifications define clinical phenotypes and determine patient outcomes in colorectal cancer

Background: A molecular classification of colorectal cancer has been proposed based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and mutations in the KRAS and BRAF oncogenes. This study examined the prevalence of these molecular classes, and differences in clinical pr...

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Veröffentlicht in:	British journal of surgery 2009-10, Vol.96 (10), p.1196-1204
Hauptverfasser:	Sanchez, J. A., Krumroy, L., Plummer, S., Aung, P., Merkulova, A., Skacel, M., DeJulius, K. L., Manilich, E., Church, J. M., Casey, G., Kalady, M. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Colorectal Neoplasms - classification Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality CpG Islands - genetics DNA Methylation - genetics Epigenesis, Genetic - genetics Female Gastroenterology. Liver. Pancreas. Abdomen General aspects Humans Kaplan-Meier Estimate Male Medical sciences Microsatellite Instability Middle Aged Mutation - genetics Oncogenes - genetics Phenotype Proportional Hazards Models Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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