Association between renal injury and reduced interleukin-15 and interleukin-15 receptor levels in acute kidney injury

Interleukin (IL)-15 serves as a survival factor for a broad array of cells. Renal cells express both IL-15 and its receptor (IL-15R); however, the role of IL-15 in the kidney is yet to be determined. We examined IL-15 and IL-15R levels in sepsis-related renal injury, ischemia-reperfusion injury (IRI...

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Veröffentlicht in:	Journal of interferon & cytokine research 2010-01, Vol.30 (1), p.1-8
Hauptverfasser:	Eini, Hadar, Tejman-Yarden, Noa, Lewis, Eli C, Chaimovitz, Cidio, Zlotnik, Moshe, Douvdevani, Amos
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute renal failure Animals Apoptosis - drug effects Caspase 3 - metabolism Cell receptors Cells, Cultured Cisplatin - toxicity Epithelial Cells - drug effects Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - pathology Genetic aspects Health aspects Interleukin-15 Interleukin-15 - genetics Interleukin-15 - metabolism Kidney Diseases - etiology Kidney Diseases - metabolism Kidney Diseases - pathology Messenger RNA Mice Mice, Inbred C57BL Mice, Knockout Physiological aspects Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Receptors, Interleukin-15 - genetics Receptors, Interleukin-15 - metabolism Reperfusion Injury - metabolism Risk factors Sepsis - complications Sepsis - immunology
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