Variants of the adiponectin gene and type 2 diabetes in a Polish population
Several association studies of type 2 diabetes mellitus (T2DM) and adiponectin gene polymorphisms have been reported with conflicting results. Our aim was to search for the association of three polymorphisms (−11.391G>A, +45T>G, and +276G>T) in the adiponectin gene with T2DM and prediabetic...
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| Veröffentlicht in: | Acta diabetologica 2009-12, Vol.46 (4), p.317-322 |
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| description | Several association studies of type 2 diabetes mellitus (T2DM) and adiponectin gene polymorphisms have been reported with conflicting results. Our aim was to search for the association of three polymorphisms (−11.391G>A, +45T>G, and +276G>T) in the adiponectin gene with T2DM and prediabetic quantitative traits in Polish Caucasians. The study groups comprised 495 unrelated T2DM cases and 435 controls. We compared the distribution of genotypes between study groups. In addition, genotype-quantitative trait analyses were also done in the controls. The study subjects were genotyped using the restriction fragment length polymorphism technique. The frequencies of the minor alleles were as follows: 10.6 versus 8.2% for −11.391G>A (
p
= 0.0722), 7.0 versus 8.0% for +45T>G (
p
= 0.48), and 15.5% in T2DM versus 19.8% in controls (
p
= 0.0145) for +276G>T, respectively. The difference for genotype distribution between the groups was statistically significant (
p
= 0.0247) for the +276G>T variant: 71.31 versus 62.99%, 26.46 versus 34.48% and 2.22 versus 2.53%, respectively, for GG, GT and TT. In quantitative traits analysis, the T allele of +276G>T was associated (
p
T were independently associated with T2DM. Finally, we conclude that the adiponectin gene polymorphisms are associated with T2DM and prediabetic quantitative traits in Polish Caucasians. |
| doi_str_mv | 10.1007/s00592-008-0091-2 |
| format | Article |
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p
= 0.0722), 7.0 versus 8.0% for +45T>G (
p
= 0.48), and 15.5% in T2DM versus 19.8% in controls (
p
= 0.0145) for +276G>T, respectively. The difference for genotype distribution between the groups was statistically significant (
p
= 0.0247) for the +276G>T variant: 71.31 versus 62.99%, 26.46 versus 34.48% and 2.22 versus 2.53%, respectively, for GG, GT and TT. In quantitative traits analysis, the T allele of +276G>T was associated (
p
< 0.05) with lower insulin resistance (HOMA-IR, fasting insulin) among controls. Additionally, the A allele at position −11.391 was associated (
p
< 0.05) with higher insulin resistance (HOMA-IR, fasting insulin). In multiple regression analysis, all identified association remained significant after the inclusion in the model of gender, BMI and age. In addition, in this model, −11.391G>A and +276G>T were independently associated with T2DM. Finally, we conclude that the adiponectin gene polymorphisms are associated with T2DM and prediabetic quantitative traits in Polish Caucasians.</description><identifier>ISSN: 0940-5429</identifier><identifier>EISSN: 1432-5233</identifier><identifier>DOI: 10.1007/s00592-008-0091-2</identifier><identifier>PMID: 19183842</identifier><identifier>CODEN: ACDAEZ</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Adiponectin - genetics ; Adult ; Aged ; Blood Glucose ; Case-Control Studies ; Diabetes ; Diabetes Mellitus, Type 2 - genetics ; Diabetes Mellitus, Type 2 - metabolism ; European Continental Ancestry Group - genetics ; Genetic Variation ; Genotype ; Genotype & phenotype ; Humans ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Minority & ethnic groups ; Original Article ; Poland ; Polymorphism ; Polymorphism, Single Nucleotide ; Population genetics</subject><ispartof>Acta diabetologica, 2009-12, Vol.46 (4), p.317-322</ispartof><rights>Springer-Verlag 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-e7d80dbb1e6db52a465d9a699e68216696812d59d6beb1d3fa69af7266da69803</citedby><cites>FETCH-LOGICAL-c468t-e7d80dbb1e6db52a465d9a699e68216696812d59d6beb1d3fa69af7266da69803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00592-008-0091-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00592-008-0091-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19183842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szopa, Magdalena</creatorcontrib><creatorcontrib>Malczewska-Malec, Malgorzata</creatorcontrib><creatorcontrib>Wilk, Beata</creatorcontrib><creatorcontrib>Skupien, Jan</creatorcontrib><creatorcontrib>Wolkow, Pawel</creatorcontrib><creatorcontrib>Malecki, Maciej T.</creatorcontrib><creatorcontrib>Sieradzki, Jacek</creatorcontrib><title>Variants of the adiponectin gene and type 2 diabetes in a Polish population</title><title>Acta diabetologica</title><addtitle>Acta Diabetol</addtitle><addtitle>Acta Diabetol</addtitle><description>Several association studies of type 2 diabetes mellitus (T2DM) and adiponectin gene polymorphisms have been reported with conflicting results. Our aim was to search for the association of three polymorphisms (−11.391G>A, +45T>G, and +276G>T) in the adiponectin gene with T2DM and prediabetic quantitative traits in Polish Caucasians. The study groups comprised 495 unrelated T2DM cases and 435 controls. We compared the distribution of genotypes between study groups. In addition, genotype-quantitative trait analyses were also done in the controls. The study subjects were genotyped using the restriction fragment length polymorphism technique. The frequencies of the minor alleles were as follows: 10.6 versus 8.2% for −11.391G>A (
p
= 0.0722), 7.0 versus 8.0% for +45T>G (
p
= 0.48), and 15.5% in T2DM versus 19.8% in controls (
p
= 0.0145) for +276G>T, respectively. The difference for genotype distribution between the groups was statistically significant (
p
= 0.0247) for the +276G>T variant: 71.31 versus 62.99%, 26.46 versus 34.48% and 2.22 versus 2.53%, respectively, for GG, GT and TT. In quantitative traits analysis, the T allele of +276G>T was associated (
p
< 0.05) with lower insulin resistance (HOMA-IR, fasting insulin) among controls. Additionally, the A allele at position −11.391 was associated (
p
< 0.05) with higher insulin resistance (HOMA-IR, fasting insulin). In multiple regression analysis, all identified association remained significant after the inclusion in the model of gender, BMI and age. In addition, in this model, −11.391G>A and +276G>T were independently associated with T2DM. Finally, we conclude that the adiponectin gene polymorphisms are associated with T2DM and prediabetic quantitative traits in Polish Caucasians.</description><subject>Adiponectin - genetics</subject><subject>Adult</subject><subject>Aged</subject><subject>Blood Glucose</subject><subject>Case-Control Studies</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>Original Article</subject><subject>Poland</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population genetics</subject><issn>0940-5429</issn><issn>1432-5233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUtLAzEUhYMotlZ_gBsJblyN5jWZZCnFFxZ0oW5DprnTTpkm42Rm0X9vSguKIC7CDTnfPZfcg9A5JdeUkOImEpJrlhGi0tE0YwdoTAVnWc44P0RjogXJcsH0CJ3EuCKEsoKrYzSimiquBBuj5w_b1db3EYcK90vA1tVt8DDva48X4NODd7jftIAZdrUtoYeIk2bxa2jquMRtaIfG9nXwp-iosk2Es32doPf7u7fpYzZ7eXia3s6yuZCqz6BwiriypCBdmTMrZO60lVqDVIxKqaWizOXayRJK6niVNFsVTEqXborwCbra-bZd-Bwg9mZdxzk0jfUQhmgKIYmihLP_SS4o46rgibz8Ra7C0Pn0DUN1rphIi04Q3UHzLsTYQWXarl7bbmMoMdtEzC4RkxIx20TMtudibzyUa3DfHfsIEsB2QEySX0D3Y_Kfrl9nEZQk</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Szopa, Magdalena</creator><creator>Malczewska-Malec, Malgorzata</creator><creator>Wilk, Beata</creator><creator>Skupien, Jan</creator><creator>Wolkow, Pawel</creator><creator>Malecki, Maciej T.</creator><creator>Sieradzki, Jacek</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20091201</creationdate><title>Variants of the adiponectin gene and type 2 diabetes in a Polish population</title><author>Szopa, Magdalena ; 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Our aim was to search for the association of three polymorphisms (−11.391G>A, +45T>G, and +276G>T) in the adiponectin gene with T2DM and prediabetic quantitative traits in Polish Caucasians. The study groups comprised 495 unrelated T2DM cases and 435 controls. We compared the distribution of genotypes between study groups. In addition, genotype-quantitative trait analyses were also done in the controls. The study subjects were genotyped using the restriction fragment length polymorphism technique. The frequencies of the minor alleles were as follows: 10.6 versus 8.2% for −11.391G>A (
p
= 0.0722), 7.0 versus 8.0% for +45T>G (
p
= 0.48), and 15.5% in T2DM versus 19.8% in controls (
p
= 0.0145) for +276G>T, respectively. The difference for genotype distribution between the groups was statistically significant (
p
= 0.0247) for the +276G>T variant: 71.31 versus 62.99%, 26.46 versus 34.48% and 2.22 versus 2.53%, respectively, for GG, GT and TT. In quantitative traits analysis, the T allele of +276G>T was associated (
p
< 0.05) with lower insulin resistance (HOMA-IR, fasting insulin) among controls. Additionally, the A allele at position −11.391 was associated (
p
< 0.05) with higher insulin resistance (HOMA-IR, fasting insulin). In multiple regression analysis, all identified association remained significant after the inclusion in the model of gender, BMI and age. In addition, in this model, −11.391G>A and +276G>T were independently associated with T2DM. Finally, we conclude that the adiponectin gene polymorphisms are associated with T2DM and prediabetic quantitative traits in Polish Caucasians.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>19183842</pmid><doi>10.1007/s00592-008-0091-2</doi><tpages>6</tpages></addata></record> |
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| subjects | Adiponectin - genetics Adult Aged Blood Glucose Case-Control Studies Diabetes Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism European Continental Ancestry Group - genetics Genetic Variation Genotype Genotype & phenotype Humans Internal Medicine Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Minority & ethnic groups Original Article Poland Polymorphism Polymorphism, Single Nucleotide Population genetics |
| title | Variants of the adiponectin gene and type 2 diabetes in a Polish population |
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