Preparation and characterization of mouse embryonic fibroblasts with K72W mutation in somatic cytochrome C gene

Mouse embryonic fibroblasts (MEF) with point mutation in somatic cytochrome C gene were generated and characterized. It was shown that the substitution of lysine for tryptophan in position 72 (K72W) decreased the proapoptotic functions of cytochrome C in response to staurosporin treatment without di...

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Veröffentlicht in:	Molecular biology (New York) 2009-08, Vol.43 (4), p.596-603
Hauptverfasser:	Mufazalov, I. A, Penkov, D. N, Chernyak, B. V, Pletjushkina, O. Y, Vyssokikh, M. Y, Chertkova, R. V, Kirpichnikov, M. P, Dolgikh, D. A, Kruglov, A. A, Kuprash, D. V, Skulachev, V. P, Nedospasov, S. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biochemistry Biomedical and Life Sciences Cell Molecular Biology Genomics Human Genetics Life Sciences Molecular biology Mutation Rodents
Online-Zugang:	Volltext
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