Bovine papillomavirus type 1 E2 and E7 proteins down-regulate Toll Like Receptor 4 ( TLR4) expression in equine fibroblasts
BPV-1 and less commonly BPV-2 are associated with the pathogenesis of equine skin tumours termed sarcoids. We recently documented the transcriptional changes that are induced by BPV-1 in equine fibroblasts using microarray analyses. TLR4 expression was found to be significantly down-regulated by BPV...
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| Veröffentlicht in: | Virus research 2010-04, Vol.149 (1), p.124-127 |
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| creator | Yuan, Z.Q. Bennett, L. Campo, M.S. Nasir, L. |
| description | BPV-1 and less commonly BPV-2 are associated with the pathogenesis of equine skin tumours termed sarcoids. We recently documented the transcriptional changes that are induced by BPV-1 in equine fibroblasts using microarray analyses.
TLR4 expression was found to be significantly down-regulated by BPV-1. In the present study, we show that
TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts. The results were confirmed by the demonstration of increased
TLR4 expression following siRNA suppression of BPV-1 E2 and E7 viral gene expression. These data imply that BPV-1 is able to subvert the innate immune response by downregulation of
TLR4. |
| doi_str_mv | 10.1016/j.virusres.2010.01.008 |
| format | Article |
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TLR4 expression was found to be significantly down-regulated by BPV-1. In the present study, we show that
TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts. The results were confirmed by the demonstration of increased
TLR4 expression following siRNA suppression of BPV-1 E2 and E7 viral gene expression. These data imply that BPV-1 is able to subvert the innate immune response by downregulation of
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TLR4 expression was found to be significantly down-regulated by BPV-1. In the present study, we show that
TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts. The results were confirmed by the demonstration of increased
TLR4 expression following siRNA suppression of BPV-1 E2 and E7 viral gene expression. These data imply that BPV-1 is able to subvert the innate immune response by downregulation of
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TLR4 expression was found to be significantly down-regulated by BPV-1. In the present study, we show that
TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts. The results were confirmed by the demonstration of increased
TLR4 expression following siRNA suppression of BPV-1 E2 and E7 viral gene expression. These data imply that BPV-1 is able to subvert the innate immune response by downregulation of
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| ispartof | Virus research, 2010-04, Vol.149 (1), p.124-127 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Bovine papillomavirus Bovine papillomavirus 1 - immunology Bovine papillomavirus 1 - pathogenicity Cells, Cultured DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - immunology Down-Regulation Equidae Fibroblasts - virology Gene Silencing Host-Pathogen Interactions Oncogene Proteins, Viral - antagonists & inhibitors Oncogene Proteins, Viral - immunology RNA, Small Interfering - genetics Toll Like Receptor 4 Toll-Like Receptor 4 - biosynthesis Viral Proteins - antagonists & inhibitors Viral Proteins - immunology |
| title | Bovine papillomavirus type 1 E2 and E7 proteins down-regulate Toll Like Receptor 4 ( TLR4) expression in equine fibroblasts |
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