Bacteroides fragilis Enterotoxin Induces Human ?-Defensin-2 Expression in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinase/IB Kinase/NF-B-Dependent Pathway

Enterotoxigenic Bacteroides fragilis (ETBF) produces an approximately 20-kDa heat-labile enterotoxin (BFT) that plays an essential role in mucosal inflammation. Although spontaneous disappearance of ETBF infection is common, little information is available on regulated expression of antibacterial fa...

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Veröffentlicht in:	Infection and immunity 2010-05, Vol.78 (5), p.2024-2033
Hauptverfasser:	Yoon, Young Mee, Lee, Jin Young, Yoo, Doyoung, Sim, Young-Suk, Kim, Young-Jeon, Oh, Yu-Kyoung, Kang, Ju Seop, Kim, Sunil, Kim, Joo Sung, Kim, Jung Mogg
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteroides fragilis Defensins Enterotoxins Epithelial cells heat-labile enterotoxin IB kinase IKK protein Infection Inflammation Intestine MAP kinase Mucosa NF-B protein Reporter gene siRNA Transfection
Online-Zugang:	Volltext
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