Nanotechnology-based systems for the treatment and prevention of HIV/AIDS
The HIV/AIDS pandemic is an increasing global burden with devastating health-related and socioeconomic effects. The widespread use of antiretroviral therapy has dramatically improved life quality and expectancy of infected individuals, but limitations of currently available drug regimens and dosage...
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| Veröffentlicht in: | Advanced drug delivery reviews 2010-03, Vol.62 (4), p.458-477 |
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| container_title | Advanced drug delivery reviews |
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| creator | das Neves, José Amiji, Mansoor M. Bahia, Maria Fernanda Sarmento, Bruno |
| description | The HIV/AIDS pandemic is an increasing global burden with devastating health-related and socioeconomic effects. The widespread use of antiretroviral therapy has dramatically improved life quality and expectancy of infected individuals, but limitations of currently available drug regimens and dosage forms, alongside with the extraordinary adapting capacity of the virus, have impaired further success. Alongside, circumventing the escalating number of new infections can only be attained with effective and practical preventative strategies. Recent advances in the field of drug delivery are providing evidence that engineered nanosystems may contribute importantly for the enhancement of current antiretroviral therapy. Additionally, groundwork is also being carried out in the field nanotechnology-based systems for developing preventative solutions for HIV transmission. This manuscript reviews recent advances in the field of nanotechnology-based systems for the treatment and prevention of HIV/AIDS. Particular attention is given to antiretroviral drug targeting to HIV reservoirs and the usefulness of nanosystems for developing topical microbicides and vaccines. |
| doi_str_mv | 10.1016/j.addr.2009.11.017 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2010-03, Vol.62 (4), p.458-477 |
| issn | 0169-409X 1872-8294 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | AIDS Vaccines - administration & dosage Anti-HIV Agents - administration & dosage Anti-HIV Agents - therapeutic use Antiretroviral therapy Central nervous system Disease Reservoirs Drug carriers Drug targeting HIV - physiology HIV Infections - economics HIV Infections - pathology HIV Infections - prevention & control HIV Infections - therapy HIV Infections - transmission HIV Infections - virology HIV reservoir sites Human immunodeficiency virus Humans Lymphatic system Macrophages Microbicides Nanotechnology - economics Nanotechnology - trends Vaccines |
| title | Nanotechnology-based systems for the treatment and prevention of HIV/AIDS |
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