Hyperechogenicity of the substantia nigra in healthy controls is related to MRI changes and to neuronal loss as determined by F-Dopa PET

Transcranial ultrasound (TCS) has been shown to reveal hyperechogenicity of the substantia nigra (SN) in Parkinsonian patients and in about 10% of healthy controls. It is hypothesized that SN hyperechogenicity in healthy subjects is a vulnerability marker for idiopathic Parkinson's disease (IPD...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2009-10, Vol.47 (4), p.1237-1243
Hauptverfasser:	Behnke, S., Schroeder, U., Dillmann, U., Buchholz, H.G., Schreckenberger, M., Fuss, G., Reith, W., Berg, D., Krick, C.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Dihydroxyphenylalanine - analogs & derivatives Echoencephalography - methods Female Humans Magnetic Resonance Imaging - methods Male Medical imaging Middle Aged Neurodegeneration Neurons - diagnostic imaging Neurons - pathology Parkinson Disease - diagnosis Positron-Emission Tomography - methods Radiopharmaceuticals Reference Values Studies Substantia Nigra - diagnostic imaging Substantia Nigra - pathology Ultrasonic imaging
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