Effects of 3-Methyl-4-nitrophenol on the Reproductive Toxicity in Female Japanese Quail (Coturnix japonica)
We previously showed that 3-methyl-4-nitrophenol (4-nitro-m-cresol, PNMC), a component of diesel exhaust particles and a degradation product of the insecticide fenitrothion, has reproductive toxicity in adult male and immature female Japanese quail (Coturnix japonica). Here we investigated effects o...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2008/11/01, Vol.31(11), pp.2158-2161 |
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| creator | Li, ChunMei Suzuki, Akira K. Takahashi, Shinji Taneda, Shinji Watanabe, Gen Taya, Kazuyoshi |
| description | We previously showed that 3-methyl-4-nitrophenol (4-nitro-m-cresol, PNMC), a component of diesel exhaust particles and a degradation product of the insecticide fenitrothion, has reproductive toxicity in adult male and immature female Japanese quail (Coturnix japonica). Here we investigated effects of PNMC on the reproductive toxicity of mature female Japanese quail. The experiment consists of 3 periods of pretreatment, treatment, and post-treatment for 5 d each. The birds were reared, bred naturally for 1 week, and after 5 d of pretreatment, then injected intramuscularly with PNMC at doses 1, 10, or 100 mg/kg body weight daily for 5 d. Body weight, egg weight, and hatchability did not differ among the observation periods. However, at all doses of PNMC, the egg-laying rate showed a modest decrease during the treatment period, with recovery during the post-treatment period. Plasma concentrations of luteinizing hormone (LH) and estrodiol-17β, were significantly decreased (p |
| doi_str_mv | 10.1248/bpb.31.2158 |
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Here we investigated effects of PNMC on the reproductive toxicity of mature female Japanese quail. The experiment consists of 3 periods of pretreatment, treatment, and post-treatment for 5 d each. The birds were reared, bred naturally for 1 week, and after 5 d of pretreatment, then injected intramuscularly with PNMC at doses 1, 10, or 100 mg/kg body weight daily for 5 d. Body weight, egg weight, and hatchability did not differ among the observation periods. However, at all doses of PNMC, the egg-laying rate showed a modest decrease during the treatment period, with recovery during the post-treatment period. Plasma concentrations of luteinizing hormone (LH) and estrodiol-17β, were significantly decreased (p<0.05), and plasma concentrations of progesterone significantly increased (p<0.05) in birds treated with 10 and 100 mg/kg PNMC. These results suggest that PNMC have acute toxicity, and inhibited LH secretion, disturbing egg-laying in mature female quail. Our findings indicate that PNMC induces endocrine malfunction at the central level and subsequently disrupts reproductive processes in mature female quails.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.31.2158</identifier><identifier>PMID: 18981592</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>3-methyl-4-nitrophenol ; Animals ; Body Weight - drug effects ; Coturnix - blood ; Coturnix - growth & development ; Coturnix japonica ; Cresols - toxicity ; diesel exhaust particle ; Dose-Response Relationship, Drug ; Endocrine Disruptors - toxicity ; Estradiol - blood ; Female ; Luteinizing Hormone - blood ; mature Japanese quail ; Organ Size - drug effects ; Progesterone - blood ; Reproduction - drug effects ; reproductive toxicity ; Toxicity Tests, Chronic</subject><ispartof>Biological and Pharmaceutical Bulletin, 2008/11/01, Vol.31(11), pp.2158-2161</ispartof><rights>2008 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-ca63787cbabe16ba862a18551987ef2aed0c319518ec76b76f9f9ab86fa27e4f3</citedby><cites>FETCH-LOGICAL-c604t-ca63787cbabe16ba862a18551987ef2aed0c319518ec76b76f9f9ab86fa27e4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18981592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, ChunMei</creatorcontrib><creatorcontrib>Suzuki, Akira K.</creatorcontrib><creatorcontrib>Takahashi, Shinji</creatorcontrib><creatorcontrib>Taneda, Shinji</creatorcontrib><creatorcontrib>Watanabe, Gen</creatorcontrib><creatorcontrib>Taya, Kazuyoshi</creatorcontrib><creatorcontrib>aEnvironmental Nanotoxicology Section Research Center for Environmental Risk National Institute for Environmental Studies</creatorcontrib><creatorcontrib>bLaboratory of Animal Reproduction College of Animal Science and Technology Nanjing Agricultural University</creatorcontrib><creatorcontrib>eDepartment of Basic Veterinary Science The United Graduate School of Veterinary Sciences Gifu University</creatorcontrib><creatorcontrib>cEcological Effect Research Team Dioxin and Environmental Endocrine Disrupter Research Project National Institute for Environmental Studies</creatorcontrib><creatorcontrib>dLaboratory of Veterinary Physiology Department of Veterinary Medicine Faculty of Agriculture Tokyo University of Agriculture and Technology</creatorcontrib><title>Effects of 3-Methyl-4-nitrophenol on the Reproductive Toxicity in Female Japanese Quail (Coturnix japonica)</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>We previously showed that 3-methyl-4-nitrophenol (4-nitro-m-cresol, PNMC), a component of diesel exhaust particles and a degradation product of the insecticide fenitrothion, has reproductive toxicity in adult male and immature female Japanese quail (Coturnix japonica). Here we investigated effects of PNMC on the reproductive toxicity of mature female Japanese quail. The experiment consists of 3 periods of pretreatment, treatment, and post-treatment for 5 d each. The birds were reared, bred naturally for 1 week, and after 5 d of pretreatment, then injected intramuscularly with PNMC at doses 1, 10, or 100 mg/kg body weight daily for 5 d. Body weight, egg weight, and hatchability did not differ among the observation periods. However, at all doses of PNMC, the egg-laying rate showed a modest decrease during the treatment period, with recovery during the post-treatment period. Plasma concentrations of luteinizing hormone (LH) and estrodiol-17β, were significantly decreased (p<0.05), and plasma concentrations of progesterone significantly increased (p<0.05) in birds treated with 10 and 100 mg/kg PNMC. These results suggest that PNMC have acute toxicity, and inhibited LH secretion, disturbing egg-laying in mature female quail. Our findings indicate that PNMC induces endocrine malfunction at the central level and subsequently disrupts reproductive processes in mature female quails.</description><subject>3-methyl-4-nitrophenol</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Coturnix - blood</subject><subject>Coturnix - growth & development</subject><subject>Coturnix japonica</subject><subject>Cresols - toxicity</subject><subject>diesel exhaust particle</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endocrine Disruptors - toxicity</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Luteinizing Hormone - blood</subject><subject>mature Japanese quail</subject><subject>Organ Size - drug effects</subject><subject>Progesterone - blood</subject><subject>Reproduction - drug effects</subject><subject>reproductive toxicity</subject><subject>Toxicity Tests, Chronic</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU2P0zAQhiMEYsvCiTuyxAEQSvHEie0codryoUUItJwtxx1TFzfOxg7a_nvcTZeVuIzlmWfeeTVTFM-BLqGq5btu6JYMlhU08kGxAFaLssmfh8WCtiBLnvNnxZMYd5RSQSv2uDgD2Upo2mpR_L6wFk2KJFjCyq-Ytgdf1mXv0hiGLfbBk9CTtEXyA4cxbCaT3B8kV-HGGZcOxPVkjXvtkXzRg-4xIvk-aefJ61VI09i7G7LTQ-id0W-eFo-s9hGfnd7z4uf64mr1qbz89vHz6v1laTitU2k0Z0IK0-kOgXda8kqDbBpopUBbadxQw6BtQKIRvBPctrbVneRWVwJry86LV7NuNnw9YUxq76JB77O_MEUlak4FryXP5Mv_yF3IprM5BXXdMt4wSjP1dqbMGGIc0aphdHs9HhRQdTyByidQDNTxBJl-cdKcuj1u7tnTzjOwnoFczWvxofeux_vJJorOBR9URalUeT4AKMrYrXwOHKTkLRx9fZiFdjHpX_hvkh6TMx7vXOXuOd723xXNVo8Ke_YX_fGu9Q</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Li, ChunMei</creator><creator>Suzuki, Akira K.</creator><creator>Takahashi, Shinji</creator><creator>Taneda, Shinji</creator><creator>Watanabe, Gen</creator><creator>Taya, Kazuyoshi</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20081101</creationdate><title>Effects of 3-Methyl-4-nitrophenol on the Reproductive Toxicity in Female Japanese Quail (Coturnix japonica)</title><author>Li, ChunMei ; Suzuki, Akira K. ; Takahashi, Shinji ; Taneda, Shinji ; Watanabe, Gen ; Taya, Kazuyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c604t-ca63787cbabe16ba862a18551987ef2aed0c319518ec76b76f9f9ab86fa27e4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>3-methyl-4-nitrophenol</topic><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Coturnix - blood</topic><topic>Coturnix - growth & development</topic><topic>Coturnix japonica</topic><topic>Cresols - toxicity</topic><topic>diesel exhaust particle</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endocrine Disruptors - toxicity</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Luteinizing Hormone - blood</topic><topic>mature Japanese quail</topic><topic>Organ Size - drug effects</topic><topic>Progesterone - blood</topic><topic>Reproduction - drug effects</topic><topic>reproductive toxicity</topic><topic>Toxicity Tests, Chronic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, ChunMei</creatorcontrib><creatorcontrib>Suzuki, Akira K.</creatorcontrib><creatorcontrib>Takahashi, Shinji</creatorcontrib><creatorcontrib>Taneda, Shinji</creatorcontrib><creatorcontrib>Watanabe, Gen</creatorcontrib><creatorcontrib>Taya, Kazuyoshi</creatorcontrib><creatorcontrib>aEnvironmental Nanotoxicology Section Research Center for Environmental Risk National Institute for Environmental Studies</creatorcontrib><creatorcontrib>bLaboratory of Animal Reproduction College of Animal Science and Technology Nanjing Agricultural University</creatorcontrib><creatorcontrib>eDepartment of Basic Veterinary Science The United Graduate School of Veterinary Sciences Gifu University</creatorcontrib><creatorcontrib>cEcological Effect Research Team Dioxin and Environmental Endocrine Disrupter Research Project National Institute for Environmental Studies</creatorcontrib><creatorcontrib>dLaboratory of Veterinary Physiology Department of Veterinary Medicine Faculty of Agriculture Tokyo University of Agriculture and Technology</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, ChunMei</au><au>Suzuki, Akira K.</au><au>Takahashi, Shinji</au><au>Taneda, Shinji</au><au>Watanabe, Gen</au><au>Taya, Kazuyoshi</au><aucorp>aEnvironmental Nanotoxicology Section Research Center for Environmental Risk National Institute for Environmental Studies</aucorp><aucorp>bLaboratory of Animal Reproduction College of Animal Science and Technology Nanjing Agricultural University</aucorp><aucorp>eDepartment of Basic Veterinary Science The United Graduate School of Veterinary Sciences Gifu University</aucorp><aucorp>cEcological Effect Research Team Dioxin and Environmental Endocrine Disrupter Research Project National Institute for Environmental Studies</aucorp><aucorp>dLaboratory of Veterinary Physiology Department of Veterinary Medicine Faculty of Agriculture Tokyo University of Agriculture and Technology</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of 3-Methyl-4-nitrophenol on the Reproductive Toxicity in Female Japanese Quail (Coturnix japonica)</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>31</volume><issue>11</issue><spage>2158</spage><epage>2161</epage><pages>2158-2161</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>We previously showed that 3-methyl-4-nitrophenol (4-nitro-m-cresol, PNMC), a component of diesel exhaust particles and a degradation product of the insecticide fenitrothion, has reproductive toxicity in adult male and immature female Japanese quail (Coturnix japonica). Here we investigated effects of PNMC on the reproductive toxicity of mature female Japanese quail. The experiment consists of 3 periods of pretreatment, treatment, and post-treatment for 5 d each. The birds were reared, bred naturally for 1 week, and after 5 d of pretreatment, then injected intramuscularly with PNMC at doses 1, 10, or 100 mg/kg body weight daily for 5 d. Body weight, egg weight, and hatchability did not differ among the observation periods. However, at all doses of PNMC, the egg-laying rate showed a modest decrease during the treatment period, with recovery during the post-treatment period. Plasma concentrations of luteinizing hormone (LH) and estrodiol-17β, were significantly decreased (p<0.05), and plasma concentrations of progesterone significantly increased (p<0.05) in birds treated with 10 and 100 mg/kg PNMC. These results suggest that PNMC have acute toxicity, and inhibited LH secretion, disturbing egg-laying in mature female quail. Our findings indicate that PNMC induces endocrine malfunction at the central level and subsequently disrupts reproductive processes in mature female quails.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>18981592</pmid><doi>10.1248/bpb.31.2158</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 3-methyl-4-nitrophenol Animals Body Weight - drug effects Coturnix - blood Coturnix - growth & development Coturnix japonica Cresols - toxicity diesel exhaust particle Dose-Response Relationship, Drug Endocrine Disruptors - toxicity Estradiol - blood Female Luteinizing Hormone - blood mature Japanese quail Organ Size - drug effects Progesterone - blood Reproduction - drug effects reproductive toxicity Toxicity Tests, Chronic |
| title | Effects of 3-Methyl-4-nitrophenol on the Reproductive Toxicity in Female Japanese Quail (Coturnix japonica) |
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