Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth

In a screen of drugs previously tested in humans we identified itraconazole, a systemic antifungal, as a potent antagonist of the Hedgehog (Hh) signaling pathway that acts by a mechanism distinct from its inhibitory effect on fungal sterol biosynthesis. Systemically administered itraconazole, like o...

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Veröffentlicht in:	Cancer cell 2010-04, Vol.17 (4), p.388-399
Hauptverfasser:	Kim, James, Tang, Jean Y., Gong, Ruoyu, Kim, Jynho, Lee, John J., Clemons, Karl V., Chong, Curtis R., Chang, Kris S., Fereshteh, Mark, Gardner, Dale, Reya, Tannishtha, Liu, Jun O., Epstein, Ervin H., Stevens, David A., Beachy, Philip A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Antineoplastic Agents - therapeutic use Carcinoma, Basal Cell - drug therapy Cell Division - drug effects CELLCYCLE CHEMBIO Cyclodextrins - pharmacology Hedgehog Proteins - antagonists & inhibitors Hedgehog Proteins - chemistry Hedgehog Proteins - drug effects Hedgehog Proteins - physiology Humans Itraconazole - pharmacology Itraconazole - therapeutic use Kinetics Lipoproteins, LDL - physiology Mice Models, Molecular Signal Transduction - drug effects
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