Human Vaccinia virus and Pseudocowpox virus co-infection: Clinical description and phylogenetic characterization
Abstract Background Occupational exanthematic diseases represent an important cause of public health impact and economical losses. Among the viral exanthematic diseases, two caused by poxviruses are noteworthy: the bovine vaccinia (BV), caused by the Vaccinia virus (VACV); and the milker's nodu...
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| Veröffentlicht in: | Journal of clinical virology 2010-05, Vol.48 (1), p.69-72 |
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| creator | Abrahão, Jônatas S Silva-Fernandes, André T Assis, Felipe L Guedes, Maria I Drumond, Betânia P Leite, Juliana A Coelho, Luiz F.L Turrini, Filippo Fonseca, Flávio G Lobato, Zélia I.P Madureira, Marieta Ferreira, Paulo C Bonjardim, Cláudio A Trindade, Giliane S Kroon, Erna G |
| description | Abstract Background Occupational exanthematic diseases represent an important cause of public health impact and economical losses. Among the viral exanthematic diseases, two caused by poxviruses are noteworthy: the bovine vaccinia (BV), caused by the Vaccinia virus (VACV); and the milker's nodule, in which the agent is the Pseudocowpox virus (PCPV). Both agents are zoonotic and have been associated with several cases of bovine infection. In Brazilian rural areas BV has been highly prevalent, particularly in milk herds. Farmers, milkers and their close contacts developed lesions on the hands, forearms, legs and face accompanied by several systemic symptoms. Although VACV and PCPV present with similar epidemiological and transmission patterns, no VACV and PCPV co-infection cases have to date been described. Objectives To describe the first case of zoonotic VACV and PCVP co-infection, based on serological and molecular methods. Study design and results In this work we report a case of a Brazilian rural worker who presented with a large severely ulcerated-pustule skin lesion, associated with fever, headache, malaise, myalgia and axillary, inguinal and cervical limphadenopathy. The worker declared occupational contact with cattle that had notable injuries on their teats. Human and bovine clinical samples were collected and submitted to serological and molecular tests. PCR and phylogenetic analysis revealed the presence of VACV DNA and PCPV DNA in the patient's lesion. Serological tests indicated anti-VACV neutralizing antibodies and molecular assays showed the presence of VACV and PCPV DNA in the patient sera. VACV and PCPV also were detected in dairy cattle. Conclusion Together, these results indicate a case of zoonotic VACV/PCPV co-infection. Epidemiological surveillance and appropriate medical treatment are essential for the control of both diseases, especially in the most severe cases, as described in the present study. |
| doi_str_mv | 10.1016/j.jcv.2010.02.001 |
| format | Article |
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Among the viral exanthematic diseases, two caused by poxviruses are noteworthy: the bovine vaccinia (BV), caused by the Vaccinia virus (VACV); and the milker's nodule, in which the agent is the Pseudocowpox virus (PCPV). Both agents are zoonotic and have been associated with several cases of bovine infection. In Brazilian rural areas BV has been highly prevalent, particularly in milk herds. Farmers, milkers and their close contacts developed lesions on the hands, forearms, legs and face accompanied by several systemic symptoms. Although VACV and PCPV present with similar epidemiological and transmission patterns, no VACV and PCPV co-infection cases have to date been described. Objectives To describe the first case of zoonotic VACV and PCVP co-infection, based on serological and molecular methods. Study design and results In this work we report a case of a Brazilian rural worker who presented with a large severely ulcerated-pustule skin lesion, associated with fever, headache, malaise, myalgia and axillary, inguinal and cervical limphadenopathy. The worker declared occupational contact with cattle that had notable injuries on their teats. Human and bovine clinical samples were collected and submitted to serological and molecular tests. PCR and phylogenetic analysis revealed the presence of VACV DNA and PCPV DNA in the patient's lesion. Serological tests indicated anti-VACV neutralizing antibodies and molecular assays showed the presence of VACV and PCPV DNA in the patient sera. VACV and PCPV also were detected in dairy cattle. Conclusion Together, these results indicate a case of zoonotic VACV/PCPV co-infection. Epidemiological surveillance and appropriate medical treatment are essential for the control of both diseases, especially in the most severe cases, as described in the present study.</description><identifier>ISSN: 1386-6532</identifier><identifier>EISSN: 1873-5967</identifier><identifier>DOI: 10.1016/j.jcv.2010.02.001</identifier><identifier>PMID: 20207192</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Allergy and Immunology ; Animals ; Antibodies ; Biological and medical sciences ; Brazil ; Cattle ; Co-infection ; Fingers - pathology ; Fingers - virology ; Fundamental and applied biological sciences. Psychology ; Human viral diseases ; Humans ; Infectious Disease ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Miscellaneous ; Orthopoxvirus ; Parapoxvirus ; Phylogeny ; Poxviridae Infections - diagnosis ; Poxviridae Infections - virology ; Pseudocowpox virus ; Pseudocowpox Virus - genetics ; Skin - pathology ; Skin - virology ; Vaccinia - virology ; Vaccinia virus ; Vaccinia virus - genetics ; Viral diseases ; Virology ; Young Adult ; Zoonoses - virology</subject><ispartof>Journal of clinical virology, 2010-05, Vol.48 (1), p.69-72</ispartof><rights>Elsevier B.V.</rights><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-f3b1e7a4165eb7da89e27c0628369ff15515ae2297e1e9d2174f8e714359a9b93</citedby><cites>FETCH-LOGICAL-c469t-f3b1e7a4165eb7da89e27c0628369ff15515ae2297e1e9d2174f8e714359a9b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcv.2010.02.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22686416$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20207192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abrahão, Jônatas S</creatorcontrib><creatorcontrib>Silva-Fernandes, André T</creatorcontrib><creatorcontrib>Assis, Felipe L</creatorcontrib><creatorcontrib>Guedes, Maria I</creatorcontrib><creatorcontrib>Drumond, Betânia P</creatorcontrib><creatorcontrib>Leite, Juliana A</creatorcontrib><creatorcontrib>Coelho, Luiz F.L</creatorcontrib><creatorcontrib>Turrini, Filippo</creatorcontrib><creatorcontrib>Fonseca, Flávio G</creatorcontrib><creatorcontrib>Lobato, Zélia I.P</creatorcontrib><creatorcontrib>Madureira, Marieta</creatorcontrib><creatorcontrib>Ferreira, Paulo C</creatorcontrib><creatorcontrib>Bonjardim, Cláudio A</creatorcontrib><creatorcontrib>Trindade, Giliane S</creatorcontrib><creatorcontrib>Kroon, Erna G</creatorcontrib><title>Human Vaccinia virus and Pseudocowpox virus co-infection: Clinical description and phylogenetic characterization</title><title>Journal of clinical virology</title><addtitle>J Clin Virol</addtitle><description>Abstract Background Occupational exanthematic diseases represent an important cause of public health impact and economical losses. Among the viral exanthematic diseases, two caused by poxviruses are noteworthy: the bovine vaccinia (BV), caused by the Vaccinia virus (VACV); and the milker's nodule, in which the agent is the Pseudocowpox virus (PCPV). Both agents are zoonotic and have been associated with several cases of bovine infection. In Brazilian rural areas BV has been highly prevalent, particularly in milk herds. Farmers, milkers and their close contacts developed lesions on the hands, forearms, legs and face accompanied by several systemic symptoms. Although VACV and PCPV present with similar epidemiological and transmission patterns, no VACV and PCPV co-infection cases have to date been described. Objectives To describe the first case of zoonotic VACV and PCVP co-infection, based on serological and molecular methods. Study design and results In this work we report a case of a Brazilian rural worker who presented with a large severely ulcerated-pustule skin lesion, associated with fever, headache, malaise, myalgia and axillary, inguinal and cervical limphadenopathy. The worker declared occupational contact with cattle that had notable injuries on their teats. Human and bovine clinical samples were collected and submitted to serological and molecular tests. PCR and phylogenetic analysis revealed the presence of VACV DNA and PCPV DNA in the patient's lesion. Serological tests indicated anti-VACV neutralizing antibodies and molecular assays showed the presence of VACV and PCPV DNA in the patient sera. VACV and PCPV also were detected in dairy cattle. Conclusion Together, these results indicate a case of zoonotic VACV/PCPV co-infection. Epidemiological surveillance and appropriate medical treatment are essential for the control of both diseases, especially in the most severe cases, as described in the present study.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Biological and medical sciences</subject><subject>Brazil</subject><subject>Cattle</subject><subject>Co-infection</subject><subject>Fingers - pathology</subject><subject>Fingers - virology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Orthopoxvirus</subject><subject>Parapoxvirus</subject><subject>Phylogeny</subject><subject>Poxviridae Infections - diagnosis</subject><subject>Poxviridae Infections - virology</subject><subject>Pseudocowpox virus</subject><subject>Pseudocowpox Virus - genetics</subject><subject>Skin - pathology</subject><subject>Skin - virology</subject><subject>Vaccinia - virology</subject><subject>Vaccinia virus</subject><subject>Vaccinia virus - genetics</subject><subject>Viral diseases</subject><subject>Virology</subject><subject>Young Adult</subject><subject>Zoonoses - virology</subject><issn>1386-6532</issn><issn>1873-5967</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl2L1DAUhoMo7rr6A7yR3ohXHfPRJo2CIIO6woKCH7chc3rqpnaSmrSj4683daqCF5qbJIfnPRze9xByn9ENo0w-7jc9HDac5j_lG0rZDXLOGiXKWkt1M79FI0tZC35G7qTUZ6AWlbpNzjjlVDHNz8l4Oe-tLz5aAOedLQ4uzqmwvi3eJpzbAOHrGL6tZQil8x3C5IJ_UmyHrAA7FC0miG5cqj-V4_VxCJ_Q4-SggGsbLUwY3Xe7EHfJrc4OCe-t9wX58PLF--1lefXm1evt86sSKqmnshM7hspWTNa4U61tNHIFVPJGSN11rK5ZbZFzrZChbjlTVdegYpWotdU7LS7Io1PfMYYvM6bJ7F0CHAbrMczJqEpSJSmX_yeFaDQVnGeSnUiIIaWInRmj29t4NIyaJRHTm5yIWRIxlJtseNY8WLvPuz22vxW_IsjAwxWwKbvZRevBpT8cl43MNmTu6YnD7NrBYTQJHHrA1sUciWmD--cYz_5SwxrfZzxi6sMcfY7DMJOywLxbVmfZHEbzqTkTPwCeI758</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Abrahão, Jônatas S</creator><creator>Silva-Fernandes, André T</creator><creator>Assis, Felipe L</creator><creator>Guedes, Maria I</creator><creator>Drumond, Betânia P</creator><creator>Leite, Juliana A</creator><creator>Coelho, Luiz F.L</creator><creator>Turrini, Filippo</creator><creator>Fonseca, Flávio G</creator><creator>Lobato, Zélia I.P</creator><creator>Madureira, Marieta</creator><creator>Ferreira, Paulo C</creator><creator>Bonjardim, Cláudio A</creator><creator>Trindade, Giliane S</creator><creator>Kroon, Erna G</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20100501</creationdate><title>Human Vaccinia virus and Pseudocowpox virus co-infection: Clinical description and phylogenetic characterization</title><author>Abrahão, Jônatas S ; Silva-Fernandes, André T ; Assis, Felipe L ; Guedes, Maria I ; Drumond, Betânia P ; Leite, Juliana A ; Coelho, Luiz F.L ; Turrini, Filippo ; Fonseca, Flávio G ; Lobato, Zélia I.P ; Madureira, Marieta ; Ferreira, Paulo C ; Bonjardim, Cláudio A ; Trindade, Giliane S ; Kroon, Erna G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-f3b1e7a4165eb7da89e27c0628369ff15515ae2297e1e9d2174f8e714359a9b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Biological and medical sciences</topic><topic>Brazil</topic><topic>Cattle</topic><topic>Co-infection</topic><topic>Fingers - pathology</topic><topic>Fingers - virology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious Disease</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Orthopoxvirus</topic><topic>Parapoxvirus</topic><topic>Phylogeny</topic><topic>Poxviridae Infections - diagnosis</topic><topic>Poxviridae Infections - virology</topic><topic>Pseudocowpox virus</topic><topic>Pseudocowpox Virus - genetics</topic><topic>Skin - pathology</topic><topic>Skin - virology</topic><topic>Vaccinia - virology</topic><topic>Vaccinia virus</topic><topic>Vaccinia virus - genetics</topic><topic>Viral diseases</topic><topic>Virology</topic><topic>Young Adult</topic><topic>Zoonoses - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abrahão, Jônatas S</creatorcontrib><creatorcontrib>Silva-Fernandes, André T</creatorcontrib><creatorcontrib>Assis, Felipe L</creatorcontrib><creatorcontrib>Guedes, Maria I</creatorcontrib><creatorcontrib>Drumond, Betânia P</creatorcontrib><creatorcontrib>Leite, Juliana A</creatorcontrib><creatorcontrib>Coelho, Luiz F.L</creatorcontrib><creatorcontrib>Turrini, Filippo</creatorcontrib><creatorcontrib>Fonseca, Flávio G</creatorcontrib><creatorcontrib>Lobato, Zélia I.P</creatorcontrib><creatorcontrib>Madureira, Marieta</creatorcontrib><creatorcontrib>Ferreira, Paulo C</creatorcontrib><creatorcontrib>Bonjardim, Cláudio A</creatorcontrib><creatorcontrib>Trindade, Giliane S</creatorcontrib><creatorcontrib>Kroon, Erna G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of clinical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abrahão, Jônatas S</au><au>Silva-Fernandes, André T</au><au>Assis, Felipe L</au><au>Guedes, Maria I</au><au>Drumond, Betânia P</au><au>Leite, Juliana A</au><au>Coelho, Luiz F.L</au><au>Turrini, Filippo</au><au>Fonseca, Flávio G</au><au>Lobato, Zélia I.P</au><au>Madureira, Marieta</au><au>Ferreira, Paulo C</au><au>Bonjardim, Cláudio A</au><au>Trindade, Giliane S</au><au>Kroon, Erna G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Vaccinia virus and Pseudocowpox virus co-infection: Clinical description and phylogenetic characterization</atitle><jtitle>Journal of clinical virology</jtitle><addtitle>J Clin Virol</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>48</volume><issue>1</issue><spage>69</spage><epage>72</epage><pages>69-72</pages><issn>1386-6532</issn><eissn>1873-5967</eissn><abstract>Abstract Background Occupational exanthematic diseases represent an important cause of public health impact and economical losses. Among the viral exanthematic diseases, two caused by poxviruses are noteworthy: the bovine vaccinia (BV), caused by the Vaccinia virus (VACV); and the milker's nodule, in which the agent is the Pseudocowpox virus (PCPV). Both agents are zoonotic and have been associated with several cases of bovine infection. In Brazilian rural areas BV has been highly prevalent, particularly in milk herds. Farmers, milkers and their close contacts developed lesions on the hands, forearms, legs and face accompanied by several systemic symptoms. Although VACV and PCPV present with similar epidemiological and transmission patterns, no VACV and PCPV co-infection cases have to date been described. Objectives To describe the first case of zoonotic VACV and PCVP co-infection, based on serological and molecular methods. Study design and results In this work we report a case of a Brazilian rural worker who presented with a large severely ulcerated-pustule skin lesion, associated with fever, headache, malaise, myalgia and axillary, inguinal and cervical limphadenopathy. The worker declared occupational contact with cattle that had notable injuries on their teats. Human and bovine clinical samples were collected and submitted to serological and molecular tests. PCR and phylogenetic analysis revealed the presence of VACV DNA and PCPV DNA in the patient's lesion. Serological tests indicated anti-VACV neutralizing antibodies and molecular assays showed the presence of VACV and PCPV DNA in the patient sera. VACV and PCPV also were detected in dairy cattle. Conclusion Together, these results indicate a case of zoonotic VACV/PCPV co-infection. Epidemiological surveillance and appropriate medical treatment are essential for the control of both diseases, especially in the most severe cases, as described in the present study.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20207192</pmid><doi>10.1016/j.jcv.2010.02.001</doi><tpages>4</tpages></addata></record> |
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| subjects | Allergy and Immunology Animals Antibodies Biological and medical sciences Brazil Cattle Co-infection Fingers - pathology Fingers - virology Fundamental and applied biological sciences. Psychology Human viral diseases Humans Infectious Disease Infectious diseases Male Medical sciences Microbiology Miscellaneous Orthopoxvirus Parapoxvirus Phylogeny Poxviridae Infections - diagnosis Poxviridae Infections - virology Pseudocowpox virus Pseudocowpox Virus - genetics Skin - pathology Skin - virology Vaccinia - virology Vaccinia virus Vaccinia virus - genetics Viral diseases Virology Young Adult Zoonoses - virology |
| title | Human Vaccinia virus and Pseudocowpox virus co-infection: Clinical description and phylogenetic characterization |
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