Effects of tributyltin (TBT) on Xenopus tropicalis embryos at environmentally relevant concentrations
Tributyltin (TBT) has been widely used as a biocide in antifouling paints and is a known endocrine disrupting chemical. In this paper, we exposed embryos of Xenopus tropicalis to 50–400 ng L −1 tributyltin chloride. TBT significantly decreased the survival rate, reduced the body length and retarded...
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| Veröffentlicht in: | Chemosphere (Oxford) 2010-04, Vol.79 (5), p.529-533 |
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| creator | Guo, Suzhen Qian, Lijuan Shi, Huahong Barry, Terence Cao, Qinzhen Liu, Junqi |
| description | Tributyltin (TBT) has been widely used as a biocide in antifouling paints and is a known endocrine disrupting chemical. In this paper, we exposed embryos of
Xenopus tropicalis to 50–400
ng
L
−1 tributyltin chloride. TBT significantly decreased the survival rate, reduced the body length and retarded the development of embryos after 24, 36 and 48
h of exposure. These effects of TBT were concentration- and time-dependent. Embryos treated with TBT showed multiple malformations. The most obvious alterations were abnormal eyes, enlarged proctodaeum, narrow fins, and skin hypopigmentation. Enlarged proctodaeum and narrow fins were mainly observed after 36 and 48
h of exposure. The loss of eye pigmentation or the absence of external eyes occurred after 24 and 36
h of exposure, while extended lenses or edemas of eyes were more commonly observed after 48
h of exposure. Additional malformations included: small anterior region of heads, pericardial edemas, enlarged trunks, and bent tails. These results suggested that TBT is very toxic to
X. tropicalis embryos at environmentally relevant concentrations. |
| doi_str_mv | 10.1016/j.chemosphere.2010.02.021 |
| format | Article |
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Xenopus tropicalis to 50–400
ng
L
−1 tributyltin chloride. TBT significantly decreased the survival rate, reduced the body length and retarded the development of embryos after 24, 36 and 48
h of exposure. These effects of TBT were concentration- and time-dependent. Embryos treated with TBT showed multiple malformations. The most obvious alterations were abnormal eyes, enlarged proctodaeum, narrow fins, and skin hypopigmentation. Enlarged proctodaeum and narrow fins were mainly observed after 36 and 48
h of exposure. The loss of eye pigmentation or the absence of external eyes occurred after 24 and 36
h of exposure, while extended lenses or edemas of eyes were more commonly observed after 48
h of exposure. Additional malformations included: small anterior region of heads, pericardial edemas, enlarged trunks, and bent tails. These results suggested that TBT is very toxic to
X. tropicalis embryos at environmentally relevant concentrations.</description><identifier>ISSN: 0045-6535</identifier><identifier>EISSN: 1879-1298</identifier><identifier>DOI: 10.1016/j.chemosphere.2010.02.021</identifier><identifier>PMID: 20202669</identifier><identifier>CODEN: CMSHAF</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Abnormalities, Drug-Induced ; Air. Soil. Water. Waste. Feeding ; Amphibian ; Animals ; Applied sciences ; Biocides ; Biological and medical sciences ; Chlorides ; Edema ; Embryo, Nonmammalian - drug effects ; Embryos ; Embryotoxicity ; Endocrine Disruptors - toxicity ; Environment. Living conditions ; Environmental Exposure ; Exact sciences and technology ; Expansion ; Eyes ; Fins ; Medical sciences ; Organotin ; Pollution ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Teratogen ; Trialkyltin Compounds - toxicity ; Water Pollutants, Chemical - toxicity ; Xenopus</subject><ispartof>Chemosphere (Oxford), 2010-04, Vol.79 (5), p.529-533</ispartof><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-5bfbc1e850c399eb1cb6e888f15ce515d65e4dbd368d05d3eeaf9275406fb91f3</citedby><cites>FETCH-LOGICAL-c438t-5bfbc1e850c399eb1cb6e888f15ce515d65e4dbd368d05d3eeaf9275406fb91f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chemosphere.2010.02.021$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22605661$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20202669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Suzhen</creatorcontrib><creatorcontrib>Qian, Lijuan</creatorcontrib><creatorcontrib>Shi, Huahong</creatorcontrib><creatorcontrib>Barry, Terence</creatorcontrib><creatorcontrib>Cao, Qinzhen</creatorcontrib><creatorcontrib>Liu, Junqi</creatorcontrib><title>Effects of tributyltin (TBT) on Xenopus tropicalis embryos at environmentally relevant concentrations</title><title>Chemosphere (Oxford)</title><addtitle>Chemosphere</addtitle><description>Tributyltin (TBT) has been widely used as a biocide in antifouling paints and is a known endocrine disrupting chemical. In this paper, we exposed embryos of
Xenopus tropicalis to 50–400
ng
L
−1 tributyltin chloride. TBT significantly decreased the survival rate, reduced the body length and retarded the development of embryos after 24, 36 and 48
h of exposure. These effects of TBT were concentration- and time-dependent. Embryos treated with TBT showed multiple malformations. The most obvious alterations were abnormal eyes, enlarged proctodaeum, narrow fins, and skin hypopigmentation. Enlarged proctodaeum and narrow fins were mainly observed after 36 and 48
h of exposure. The loss of eye pigmentation or the absence of external eyes occurred after 24 and 36
h of exposure, while extended lenses or edemas of eyes were more commonly observed after 48
h of exposure. Additional malformations included: small anterior region of heads, pericardial edemas, enlarged trunks, and bent tails. These results suggested that TBT is very toxic to
X. tropicalis embryos at environmentally relevant concentrations.</description><subject>Abnormalities, Drug-Induced</subject><subject>Air. Soil. Water. Waste. Feeding</subject><subject>Amphibian</subject><subject>Animals</subject><subject>Applied sciences</subject><subject>Biocides</subject><subject>Biological and medical sciences</subject><subject>Chlorides</subject><subject>Edema</subject><subject>Embryo, Nonmammalian - drug effects</subject><subject>Embryos</subject><subject>Embryotoxicity</subject><subject>Endocrine Disruptors - toxicity</subject><subject>Environment. Living conditions</subject><subject>Environmental Exposure</subject><subject>Exact sciences and technology</subject><subject>Expansion</subject><subject>Eyes</subject><subject>Fins</subject><subject>Medical sciences</subject><subject>Organotin</subject><subject>Pollution</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Teratogen</subject><subject>Trialkyltin Compounds - toxicity</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Xenopus</subject><issn>0045-6535</issn><issn>1879-1298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFrHCEUxyU0NNukX6HYQ2l7mI3OjO54TJa0KQRy2UBuos6TuMzoVJ2F_fZ12U3bY_CB8Pz9n_IToc-ULCmh_Hq7NC8whjS9QIRlTUqf1KXoGVrQbiUqWovuHVoQ0rKKs4ZdoA8pbQkpYSbeo4ualMW5WCC4sxZMTjhYnKPTc94P2Xn8bXO7-Y6Dx8_gwzSnchgmZ9TgEoZRx31IWGUMfudi8CP4rIZhjyMMsFM-YxO8Kc2osgs-XaFzq4YEH0_7JXr6cbdZ31cPjz9_rW8eKtM2Xa6YttpQ6BgxjRCgqdEcuq6zlBlglPWcQdvrvuFdT1jfACgr6hVrCbdaUNtcoq_HuVMMv2dIWY4uGRgG5SHMSa5aTlaMtbyQ4kiaGFKKYOUU3ajiXlIiD5LlVv4nWR4kS1KXoiX76XTLrEfo_yZfrRbgywlQqSizUXnj0j-u5oRxfhi0PnJQnOwcRJmMgyKud7F8iuyDe8Nz_gAKkqNZ</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Guo, Suzhen</creator><creator>Qian, Lijuan</creator><creator>Shi, Huahong</creator><creator>Barry, Terence</creator><creator>Cao, Qinzhen</creator><creator>Liu, Junqi</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope></search><sort><creationdate>20100401</creationdate><title>Effects of tributyltin (TBT) on Xenopus tropicalis embryos at environmentally relevant concentrations</title><author>Guo, Suzhen ; Qian, Lijuan ; Shi, Huahong ; Barry, Terence ; Cao, Qinzhen ; Liu, Junqi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-5bfbc1e850c399eb1cb6e888f15ce515d65e4dbd368d05d3eeaf9275406fb91f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Abnormalities, Drug-Induced</topic><topic>Air. 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In this paper, we exposed embryos of
Xenopus tropicalis to 50–400
ng
L
−1 tributyltin chloride. TBT significantly decreased the survival rate, reduced the body length and retarded the development of embryos after 24, 36 and 48
h of exposure. These effects of TBT were concentration- and time-dependent. Embryos treated with TBT showed multiple malformations. The most obvious alterations were abnormal eyes, enlarged proctodaeum, narrow fins, and skin hypopigmentation. Enlarged proctodaeum and narrow fins were mainly observed after 36 and 48
h of exposure. The loss of eye pigmentation or the absence of external eyes occurred after 24 and 36
h of exposure, while extended lenses or edemas of eyes were more commonly observed after 48
h of exposure. Additional malformations included: small anterior region of heads, pericardial edemas, enlarged trunks, and bent tails. These results suggested that TBT is very toxic to
X. tropicalis embryos at environmentally relevant concentrations.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20202669</pmid><doi>10.1016/j.chemosphere.2010.02.021</doi><tpages>5</tpages></addata></record> |
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| subjects | Abnormalities, Drug-Induced Air. Soil. Water. Waste. Feeding Amphibian Animals Applied sciences Biocides Biological and medical sciences Chlorides Edema Embryo, Nonmammalian - drug effects Embryos Embryotoxicity Endocrine Disruptors - toxicity Environment. Living conditions Environmental Exposure Exact sciences and technology Expansion Eyes Fins Medical sciences Organotin Pollution Public health. Hygiene Public health. Hygiene-occupational medicine Teratogen Trialkyltin Compounds - toxicity Water Pollutants, Chemical - toxicity Xenopus |
| title | Effects of tributyltin (TBT) on Xenopus tropicalis embryos at environmentally relevant concentrations |
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