Antimicrobial peptides: General overview and clinical implications in human health and disease
Abstract Antimicrobial peptides (AMPs) are evolutionarily conserved molecules involved in the defense mechanisms of a wide range of organisms. Produced in bacteria, insects, plants and vertebrates, AMPs protect against a broad array of infectious agents. In mammals these peptides protect against bac...
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| Veröffentlicht in: | Clinical immunology (Orlando, Fla.) Fla.), 2010-04, Vol.135 (1), p.1-11 |
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| creator | Guaní-Guerra, Eduardo Santos-Mendoza, Teresa Lugo-Reyes, Saúl O Terán, Luis M |
| description | Abstract Antimicrobial peptides (AMPs) are evolutionarily conserved molecules involved in the defense mechanisms of a wide range of organisms. Produced in bacteria, insects, plants and vertebrates, AMPs protect against a broad array of infectious agents. In mammals these peptides protect against bacteria, viruses, fungi, and certain parasites. Recently, novel biologic effects of AMPs have been documented such as endotoxin neutralization, chemotactic and immunomodulating activities, induction of angiogenesis and wound repair. Thus these ancestral molecules are crucial components of the innate immune system and attractive candidates for novel therapeutic approaches. This review focuses on cathelicin and defensins, the most documented human AMPs, and discusses their antimicrobial activity and pleiotropic immunomodulating effects on inflammatory and infectious diseases. |
| doi_str_mv | 10.1016/j.clim.2009.12.004 |
| format | Article |
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Produced in bacteria, insects, plants and vertebrates, AMPs protect against a broad array of infectious agents. In mammals these peptides protect against bacteria, viruses, fungi, and certain parasites. Recently, novel biologic effects of AMPs have been documented such as endotoxin neutralization, chemotactic and immunomodulating activities, induction of angiogenesis and wound repair. Thus these ancestral molecules are crucial components of the innate immune system and attractive candidates for novel therapeutic approaches. This review focuses on cathelicin and defensins, the most documented human AMPs, and discusses their antimicrobial activity and pleiotropic immunomodulating effects on inflammatory and infectious diseases.</description><identifier>ISSN: 1521-6616</identifier><identifier>EISSN: 1521-7035</identifier><identifier>DOI: 10.1016/j.clim.2009.12.004</identifier><identifier>PMID: 20116332</identifier><identifier>CODEN: CLIIFY</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Allergy and Immunology ; Angiogenesis ; Antimicrobial Cationic Peptides - immunology ; Antimicrobial Cationic Peptides - pharmacology ; Antimicrobial peptides ; Biological and medical sciences ; Cathelicidin ; Cathelicidins - immunology ; Cathelicidins - pharmacology ; Defensins ; Defensins - immunology ; Defensins - pharmacology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Host defense ; Humans ; Immunity, Innate - immunology ; Immunomodulation - immunology ; Innate immunity</subject><ispartof>Clinical immunology (Orlando, Fla.), 2010-04, Vol.135 (1), p.1-11</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2009 Elsevier Inc. 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Produced in bacteria, insects, plants and vertebrates, AMPs protect against a broad array of infectious agents. In mammals these peptides protect against bacteria, viruses, fungi, and certain parasites. Recently, novel biologic effects of AMPs have been documented such as endotoxin neutralization, chemotactic and immunomodulating activities, induction of angiogenesis and wound repair. Thus these ancestral molecules are crucial components of the innate immune system and attractive candidates for novel therapeutic approaches. This review focuses on cathelicin and defensins, the most documented human AMPs, and discusses their antimicrobial activity and pleiotropic immunomodulating effects on inflammatory and infectious diseases.</description><subject>Allergy and Immunology</subject><subject>Angiogenesis</subject><subject>Antimicrobial Cationic Peptides - immunology</subject><subject>Antimicrobial Cationic Peptides - pharmacology</subject><subject>Antimicrobial peptides</subject><subject>Biological and medical sciences</subject><subject>Cathelicidin</subject><subject>Cathelicidins - immunology</subject><subject>Cathelicidins - pharmacology</subject><subject>Defensins</subject><subject>Defensins - immunology</subject><subject>Defensins - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Host defense</subject><subject>Humans</subject><subject>Immunity, Innate - immunology</subject><subject>Immunomodulation - immunology</subject><subject>Innate immunity</subject><issn>1521-6616</issn><issn>1521-7035</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkFv1DAQhSMEoqXwBzigXBCnDTPjxN4ghFRVUJAqcQCuWF57onpJnGAnRf33OOwWJA5wsD0afW9sveeieIpQIaB8ua9s74eKANoKqQKo7xWn2BBuFIjm_rGWEuVJ8SilPQA0RPJhcUKAKIWg0-LreZj94G0cd9705cTT7B2nV-UlB465M95wvPH8ozTBlfm-4G3u-mHqczH7MaTSh_J6GUze2fTz9S_S-cQm8ePiQWf6xE-O51nx5d3bzxfvN1cfLz9cnF9tbK1o3rDdtsrWLShCB9xS1zZq2wISNTsGVkyWUTqjyBrrtt3Odug6YZ3pFBkrzooXh7lTHL8vnGY9-GS5703gcUla1RJUU2Pzf1IIhRKEzCQdyGxOSpE7PUU_mHirEfQagN7rNQC9BqCRdA4gi54dxy-7gd1vyZ3jGXh-BEzKTnbRBOvTH44aCXll7vWB42xbDiDqZD0Hy85HtrN2o__3O978Jb_L7hvfctqPSww5EI06ZYH-tH6V9adAm4cgKfETTqy5sg</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Guaní-Guerra, Eduardo</creator><creator>Santos-Mendoza, Teresa</creator><creator>Lugo-Reyes, Saúl O</creator><creator>Terán, Luis M</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope></search><sort><creationdate>20100401</creationdate><title>Antimicrobial peptides: General overview and clinical implications in human health and disease</title><author>Guaní-Guerra, Eduardo ; Santos-Mendoza, Teresa ; Lugo-Reyes, Saúl O ; Terán, Luis M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-ec897c490721d0e92f9578901225be0e7e2ce16da72cacd8fbcf1df3cdaf72ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Allergy and Immunology</topic><topic>Angiogenesis</topic><topic>Antimicrobial Cationic Peptides - immunology</topic><topic>Antimicrobial Cationic Peptides - pharmacology</topic><topic>Antimicrobial peptides</topic><topic>Biological and medical sciences</topic><topic>Cathelicidin</topic><topic>Cathelicidins - immunology</topic><topic>Cathelicidins - pharmacology</topic><topic>Defensins</topic><topic>Defensins - immunology</topic><topic>Defensins - pharmacology</topic><topic>Fundamental and applied biological sciences. 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Produced in bacteria, insects, plants and vertebrates, AMPs protect against a broad array of infectious agents. In mammals these peptides protect against bacteria, viruses, fungi, and certain parasites. Recently, novel biologic effects of AMPs have been documented such as endotoxin neutralization, chemotactic and immunomodulating activities, induction of angiogenesis and wound repair. Thus these ancestral molecules are crucial components of the innate immune system and attractive candidates for novel therapeutic approaches. This review focuses on cathelicin and defensins, the most documented human AMPs, and discusses their antimicrobial activity and pleiotropic immunomodulating effects on inflammatory and infectious diseases.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>20116332</pmid><doi>10.1016/j.clim.2009.12.004</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Allergy and Immunology Angiogenesis Antimicrobial Cationic Peptides - immunology Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptides Biological and medical sciences Cathelicidin Cathelicidins - immunology Cathelicidins - pharmacology Defensins Defensins - immunology Defensins - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology Host defense Humans Immunity, Innate - immunology Immunomodulation - immunology Innate immunity |
| title | Antimicrobial peptides: General overview and clinical implications in human health and disease |
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