Oxidative stress resistance through blocking Hsp60 translocation followed by SAPK/JNK inhibition in aged human diploid fibroblasts

The stress‐activated protein kinase/c‐Jun N‐terminal kinase (SAPK/JNK) pathway is a well‐known senescence‐related stress activated protein kinase. Multiple environmental stresses induce programmed cell death, such as apoptosis. Normal human diploid fibroblast (HDF) cells have a limited life span in...

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Veröffentlicht in:	Cell biochemistry and function 2009-01, Vol.27 (1), p.35-39
Hauptverfasser:	Lee, Young-Hee, Govinda, Bhattarai, Kim, Jae-Cheol, Kim, Tae-Il, Lee, Nan-Hee, Lee, Jung-Chang, Yi, Ho-Keun, Jhee, Eun-Chung
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracenes - pharmacology Apoptosis - drug effects Apoptosis - physiology Cell Division - drug effects Cell Division - physiology Cells, Cultured Cellular Senescence - drug effects Cellular Senescence - physiology Chaperonin 60 - metabolism Diploidy Fibroblasts - cytology Fibroblasts - metabolism heat shock protein60 human diploid fibroblasts Humans Male MAP Kinase Kinase 4 - antagonists & inhibitors MAP Kinase Kinase 4 - metabolism Mitochondria - metabolism Mitochondrial Proteins - metabolism Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - metabolism oxidative stress Oxidative Stress - physiology Protein Transport - drug effects Protein Transport - physiology SAPK/JNK SP600125 SAPK/JNK inhibitor
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